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21.
Antifungal Activity of Propolis Against Yeasts Isolated From Blood Culture: In Vitro Evaluation
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Fatma Mutlu Sariguzel Elife Berk Ayes Nedret Koc Hafize Sav Gonca Demir 《Journal of clinical laboratory analysis》2016,30(5):513-516
Background: Due to the failure of available antifungal agents in the treatment of candidemia and the toxic activities of these drugs, a lot of researches are being conducted to develop new nontoxic and effective antifungal agents for optimal control of fungal pathogens. The aim of this study is to evaluate the in vitro antifungal activity of propolis against yeasts isolated from the blood cultures of intensive care unit patients. Methods: Seventy‐six strains were included in this study. The in vitro antifungal activity of propolis, fluconazole (FLU), and itraconazole (ITR) was investigated by the microdilution broth methods (CLSI guidelines M27‐A3 for yeast). The propolis sample was collected from Kayseri, Turkey. Results: Of the 76 isolates, 33 were identified as Candida albicans while 37 were C. parapsilosis, three were C. tropicalis, and three were identified as C. glabrata. The geometric mean range for MIC (μg/ml) with regard to all isolates was 0.077 to 3 μg/ml for FLU and ITR, and 0.375 to 0.70 μg/ml for propolis. It was shown that propolis had significant antifungal activity against all Candida strains and the MIC range of propolis was determined as 0185 to 3 μg/ml. Conclusion: This study demonstrated that propolis had significant antifungal activity against yeasts isolated from blood culture compared with FLU and ITR. The propolis MIC in azole‐resistant strains such as C. glabrata was found lower than the FLU MIC. 相似文献
22.
Rosiglitazone Attenuates Liver Inflammation in a Rat Model of Nonalcoholic Steatohepatitis 总被引:1,自引:0,他引:1
Tahan V Eren F Avsar E Yavuz D Yuksel M Emekli E Imeryuz N Celikel C Uzun H Haklar G Tozun N 《Digestive diseases and sciences》2007,52(12):3465-3472
Rosiglitazone is an insulin-sensitizing agent. We aimed to assess the effects of rosiglitazone on a methionine- and choline-deficient
diet (MCDD) model of nonalcoholic steatohepatitis (NASH) in rats. Wistar rats were fed either MCDD or a control diet in the
4-week induction study; they were given saline or 4 mg/kg/day rosiglitazone. After the induction study period, the rats were
divided into four groups and fed MCDD or given a control diet for an additional 8 weeks and received saline or rosiglitazone.
Serum and tissue samples were obtained. Rosiglitazone improved inflammation in NASH and improved ALT, alkaline phosphatase,
and interleukin-6 levels in the induction study and interleukin-1β, interleukin-6, and tumor necrosis factor-α levels in the
treatment study. Our preliminary study is the first to show the anti-inflammatory effects of rosiglitazone in NASH. Rosiglitazone’s
effect on cytokines may be a key mechanism of its anti-inflammatory effect in NASH. 相似文献
23.
24.
Mehmet Ali Cikrikcioglu Mehmet Hursitoglu Hafize Erkal Nilay Guler Karaca Sati Coraoglu Tufan Tukek 《Central European Journal of Medicine》2009,4(4):444-449
Our case involves a 53 year old woman. Three years ago, she was investigated because of normal hemoglobin levels despite very
a low erythrocyte count, which was revealed during the preoperative evaluation for ovarian cyst operation. The Direct Coombs
test was found to be positive against complement and negative against IgG. Cold agglutinin titer was 1/448 (+). Due to the
polyclonal IgM increase, secondary cold agglutinin disease (CAD) was considered but no factor could be found that would lead
to cold agglutinin disease. During the post-operative follow-up, cold agglutinin titers increased with fluctuations in the
patient. Twenty-four months after transabdominal hysterectomy and bilateral salpingooopherectomy operation, diagnosis of Hashimoto
disease was made upon detection of subclinical hypothyroidism. No case of Hashimoto disease associated with CAD caused by
polyclonal IgM has been reported until the present time. 相似文献
25.
Yildirim M Sahin I Kucukbayrak A Ozdemir D Tevfik Yavuz M Oksuz S Cakir S 《Mycoses》2007,50(3):189-192
The hands of healthcare workers (HCWs) are considered to be important for colonisation and infection of Candida spp. The objective of this study was to evaluate the rate of Candida carriage on the hands of the hospital personnel the potential risk factors. Samples were collected from the hands of 214 (139 female and 75 male) hospital personnel working at Duzce Medical Faculty Hospital, Duzce, Turkey. Of these, 88 were nurses, 62 resident doctors, 21 laboratory workers, 30 officers and 13 dining room personnel. The hands of all participants were tested by culture with the broth wash technique. Overall, 34.1% of the people analysed were found to harbour Candida spp. on their hands: 30.7% were nurses, 25.8% resident doctors, 28.6% laboratory workers, 84.6% dining room personnel and 43.3% officers. Candida carriage rates of the dining room personnel were higher than found in the other groups (P = 0.001). Isolated Candida species were C. parapsilosis (38.4%), C. tropicalis (26.0%), C. albicans (23.3%), C. kefyr (11.0%) and C. globosa (1.4%). Candida carriage rate was higher in the glove-using group (35.1%) than the non-glove using group (7.1%, P = 0.031). We concluded that carriage of Candida species on the hands of personnel was common especially in non-medical staff. Wearing gloves was found to be related to increased rates of Candida carriage in the nurse group. Candida parapsilosis was the most frequently colonising species that may be a predisposing condition for nosocomial infections transmitted with the hands of HCWs. Hospital personnel should be educated for regular hand washing practice for preventing Candida colonisation. 相似文献
26.
OBJECTIVE: Our objective was to assess the frequency and clinical characteristics of migraine in the patients with CM-1. METHODS: We analyzed migraine in 73 patients with CM-1. Migraine was classified according to the new International Headache Society criteria. We did not include patients who had intracranial, parenchymal, or cervical lesions other than CM-1 on brain and cervical magnetic resonance imaging. RESULTS: Of the 73 patients diagnosed as having CM-1, 11 (15.06%) had migraines; of them, 8 (10.95%) had chronic migraines, 2 (2.73%) had migraines with auras, and 1 (1.36%) had migraines without auras. The patients who had both migraines and CM-1 (group 1) were compared regarding clinical characteristics and demographic features to the control group having chronic migraines. The control group comprised subjects free of CM-1. Onset age of pain was earlier and the frequency of headache days per month, baseline pain intensity, exacerbation of pain intensity, nausea, vomiting, and pain aggravated by physical activity were significantly higher in group 1. CONCLUSIONS: Although we found the frequency of migraine to be similar to that in population-based studies, we detected a threefold increased frequency of chronic migraine in this special population. We believe that CM-1 may be a factor associated with chronic migraine. 相似文献
27.
Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner‐masked,randomized, controlled clinical trial
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Selin Yıldırım Hafize Öztürk Özener Başak Doğan Bahar Kuru 《Journal of periodontology》2018,89(1):36-45
1 Background
This study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery.2 Methods
Thirty‐six patients requiring FGG were randomly assigned into three groups in an examiner‐masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42.3 Results
Test groups experienced less pain than the control group on days 3 and 7 (P <0.001 and P <0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P <0.001 and P <0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively).4 Conclusion
Topical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match. 相似文献28.
M Gokce MF Yuzbasioglu E Bulbuloglu H Oksuz S Yormaz O Altınoren M Kutlucan I Coskuner E Silay IT Kale 《Transplantation proceedings》2012,44(6):1738-1742
Aim
Cyclosporine (CsA), an important agent used in organ transplantation to prevent rejection, displays nephrotoxicity as the most important side effect limiting usage. In this study, we sought to evaluate the effects of cilostazol and diltiazem to counter the nephrotoxicity induced by the calcineurin inhibitor CsA.Materials and methods
Animals were randomly divided into seven groups, each consisting of eight animals: sham, controls, cilostazol, diltiazem, CsA, CsA plus diltiazem, and CsA plus cilostazol treatment. At the end of a 60-minute ischemic period, we administered the drugs after reperfusion for 7 days thereafter. CsA (10 mg/kg/d) was intraperitoneally for 7 days; cilostazol (10 mg/kg/d) orally by catheter for 7 days; diltiazem (5 mg/kg/d) intraperitoneally for 7 days. At the end of the 7-day treatment period, blood and tissue samples were harvested for biochemical, and serological evaluation.Results
Ischemia-reperfusion injury significantly increased malondialdehyde (MDA) levels as well as decreased catalase (CAT) activities and superoxide dysmutase (SOD) content. The lowest MDA mean level was observed in the diltiazem and, the highest in the control group. The lowest CAT mean levels were noted in the CsA and diltiazem groups with highest CAT content was in the CsA and cilostazol groups. The lowest SOD mean level occurred in the sham group; the highest, in the CsA group.Conclusion
Cilostazol and especially diltiazem were effective to mitigate renal ischemia-reperfusion injury. 相似文献29.
Ahmet Gulcubuk Damla Haktanir Aris Cakiris Duran Ustek Ozlem Guzel Muzaffer Erturk Murat Karabagli Ibrahim Akyazi Hayriye Cicekci Kemal Altunatmaz Hafize Uzun Kenan Ates 《Pancreatology》2013,13(4):347-354
Background & aimsAcute pancreatitis (AP) varies from mild to severe necrotizing changes with high mortality. The objective of the current study was to investigate the effects of curcumin on tissue injury and proinflammatory cytokines in the early and late phases of AP.MethodsAP was induced by sodium taurocholate in rats (n = 140). First group was left untreated. Group II received 100 mg/kg curcumin daily starting 20 days before AP induction. The rats were allocated into 7 sub-groups (n:5) and were sacrificed at 2, 6, 12, 24, 72, 144 and 288 h following the induction of AP. Blood and pancreatic tissue samples were collected for biochemical and histopathologic evaluations and the assessment of protein and mRNA levels, as well.ResultsCurcumin decreased total histopathologic scores in comparison with those of the taurocholate group (P < 0.05). Curcumin increased Caspase-3 activity and decreased trypsin activity, while inhibited nuclear factor-κ (NF-κB) at all time points (P < 0.05) and moreover reduced activator protein-1 (AP-1). Curcumin decreased chemokine (except for 288 h), TNF-α (except for 2 and 24 h), IL-6 (except for 2, 6 and 288 h) and iNOS (except for 144 and 288 h) mRNA levels (P < 0.05). Curcumin serum nitric oxide (NO) (except for 144 and 288 h) levels were reduced, as well.ConclusionsIn conclusion, curcumin reduced tissue injury, trypsin activation and inhibited NF-κB and AP-1. However TNF-α, IL-6 and iNOS and NO were not inhibited at all time points. Therefore no direct correlation was detected in the subgroups between tissue injury, proinflammatory cytokines and oxidative enzymes. 相似文献
30.
Ezra etinkaya eyma Yldz Hafize Otu Rasul Sharifov Fatma elik Yabul Alpay Alkan 《Diagnostic and interventional radiology (Ankara, Turkey)》2022,28(5):463
PURPOSE The aim of this study was to evaluate the prognostic quality of adjacent vessel sign (AVS) in malignant breast tumors by comparing it with classical prognostic pathological biomarkers and magnetic resonance imaging (MRI) findings.METHODS A total of 124 patients with 133 malignant lesions were included. All the imaging was performed on a 1.5T Avanto scanner and the images were interpreted according to BI-RADS-MR® (fifth ed.) atlas. Maximum intensity projection (MIP) images were constructed from subtracted post-contrast images and were used to investigate AVS. Histopathological results and MRI findings were compared with AVS.RESULTS Interobserver agreement about AVS status was substantial (κ = 0.64). AVS positive lesions were significantly bigger in size (P < .001, AVS negative: median 12 mm, AVS positive: median 31 mm). AVS was significantly associated with increased Ki-67 index and axillary lymph node metastasis (P = .009 and P = .019, respectively). Between AVS and lymphovascular invasion (LVI), there was a trend toward positive relationship (P = .076). MRI findings of T2 hypointensity, peritumoral edema, irregular shape, non-homogeneous contrast enhancement, rapid early contrast enhancement, and skin infiltration showed significant positive relation with AVS (P < .001, P < .001, P < .001, P = .02, P = .021, and P = .021, respectively). AVS is found to be associated with increased Ki-67 index, axillary lymph node metastasis, and some MRI findings that point to malignancy or poor prognosis.CONCLUSION AVS indicates poor prognosis since it is related to axillary lymph node metastasis, increased Ki-67 index, LVI, peritumoral edema, rapid early contrast enhancement, increased background enhancement, skin extension, T2 hypointensity, non-homogeneous contrast enhancement, irregular lesion shape, and larger tumor size. AVS is an easy to use sign that shows substantial interobserver agreement.Main points
- Adjacent vessel sign (AVS) shows poor prognosis since it is related to axillary lymph node metastasis, increased Ki-67 index, lymphovascular invasion, peritumoral edema, rapid early contrast enhancement, increased background enhancement, and skin extension.
- AVS is also associated with T2 hypointensity, non-homogeneous contrast enhancement, irregular lesion shape, and larger tumor size which all point out malignant lesion character.
- AVS is an easily and rapidly applicable sign showing substantial interobserver agreement.