Central nervous system lymphoma in a patient with Sjogren’s syndrome and autoimmune thyroiditis (Hashimoto’s thyroiditis)

We present a case of central nervous system (CNS) lymphoma in a patient with Sjogren’s syndrome (SS) and autoimmune thyroiditis (Hashimoto’s thyroiditis) overlap. A 60-year-old woman, who had the diagnosis of SS for 16 years, had been admitted for visual loss, fever, weight and appetite loss for 3 months. Cranial magnetic resonance imaging was in accordance with CNS lymphoma, and biopsy from right parietal region showed diffuse large B-cell lymphoma of the CNS. This is the first report of diffuse large B-cell lymphoma of the CNS in SS and autoimmune thyroiditis (Hashimoto’s thyroiditis) overlap.     

Chilling-Like Attacks Terminated by Slow Pathway Ablation

Symptoms of patients or the way of presenting complaints by the patients may be indefinite, obscure or misleading for the diagnosis of supraventricular tachycardia. The content of the history shows variability depending on the present symptoms, patient concerns and priority. Herein, an unusual case of a young woman suffering from chilling-like attacks for one and half years and treated by slow pathway ablation has been presented.     

Protective role of ascorbic acid on subacute sperm toxicity in male New Zealand white rabbits treated with endosulfan

The ameliorating effect of oral ascorbic acid (AA) was evaluated against changes in sperm parameters in New Zealand White (NZW) rabbits treated with endosulfan. Rabbits (6 to 8 months old) were divided into four groups of six animals each. Rabbits in TRT-I served as control and received corn oil by oral gavage for 6 weeks. Rabbits in TRT-II received endosulfan (1 mg/kg bw per day) in corn oil. TRT-III group received oral corn oil daily and ascorbic acid (AA; 20 mg/kg bw) every other day for 6 weeks. TRT-IV group received the same amounts of endosulfan and AA. Endosulfan alone significantly reduced the sperm count and motility and increased the presence of sperm with morphologic problems. AA treatment showed significant amelioration when coupled with endosulfan. Ameliorations were up to control levels in all cases except for sperm motility. The data suggested that AA has beneficial influences in neutralizing the toxic effects of endosulfan in the spermatologic parameters of NZW males.     

Diagnosis and treatment of osteopenia

Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score −1 to −2.5. There are many causes for osteopenia including calcium and vitamin D deficiency and inactivity. Genetics plays an important role in a person’s bone mineral density and often Caucasian women with a thin body habitus who are premenopausal are found to have osteopenia. Correction of calcium and vitamin D deficiency and walking 3 to 5 miles a week can often improve bone density in the hip and spine. There are a variety of pharmaceutical agents that have been recommended for the treatment of osteopenia and osteoporosis including hormone replacement therapy, selective estrogen receptor modulator therapy, anti-resorptive therapy. In addition patients with osteoporosis who have failed anti-resorptive therapy can have a significant improvement in their bone density with anabolic therapy.     

Pregnancy- and lactation-associated osteoporosis with severe vertebral deformities: can strontium ranelate be a new alternative for the treatment?

Background contextPregnancy- and lactation-associated osteoporosis is an uncommon condition that may be a consequence of preexisting low bone density, loss of bone mineral content during pregnancy, and increased bone turnover.PurposeTo present a case of severe osteoporosis associated with pregnancy and lactation and its treatment protocol.Study design/settingA tertiary care hospital.Patient sampleA young female after twin pregnancy presenting with severe osteoporosis.MethodsThe diagnosis was done on the basis of bone mineral density (BMD) measurement. The patient was treated with first alendronate and then strontium ranelate. She was considered as a candidate for kyphoplasty.ResultsA dramatic increase in the BMD and palliation of back pain were observed.ConclusionsStrontium ranelate may be a new alternative in the treatment of pregnancy- and lactation-associated osteoporosis.     

Outcome of surgical treatment of intestinal perforation in typhoid fever

AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair foll...