全文获取类型
收费全文 | 272篇 |
免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 17篇 |
基础医学 | 20篇 |
临床医学 | 29篇 |
内科学 | 32篇 |
皮肤病学 | 7篇 |
神经病学 | 8篇 |
特种医学 | 6篇 |
外科学 | 84篇 |
综合类 | 1篇 |
预防医学 | 17篇 |
眼科学 | 3篇 |
药学 | 21篇 |
肿瘤学 | 25篇 |
出版年
2023年 | 3篇 |
2021年 | 3篇 |
2018年 | 5篇 |
2015年 | 6篇 |
2014年 | 5篇 |
2013年 | 16篇 |
2012年 | 9篇 |
2011年 | 11篇 |
2010年 | 2篇 |
2009年 | 5篇 |
2008年 | 9篇 |
2007年 | 7篇 |
2006年 | 11篇 |
2005年 | 29篇 |
2004年 | 3篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 9篇 |
2000年 | 8篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1995年 | 3篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 5篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 11篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1972年 | 5篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1969年 | 8篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1966年 | 3篇 |
1935年 | 1篇 |
排序方式: 共有279条查询结果,搜索用时 15 毫秒
91.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):639-646
Functional disability secondary to acute low-back pain, chronic low-back pain, lumbar stenosis, and lumbar disc disease may be reliably and validly assessed using functional outcome surveys that are valid, reliable, and responsive. Outcome instruments supported by Class I and Class II medical evidence for the evaluation of low-back pain include the Spinal Stenosis Survey of Stucki, Waddell-Main, RMDQ, DPQ, QPDS, SIP, Million Scale, LBPR Scale, ODI, and CBSQ. Many of these outcome measures have been applied to patients who have been treated with lumbar fusion for degenerative lumbar disease and have proven to be valid and responsive; however, the reliability of these instruments has never been specifically assessed in the lumbar fusion patient population. Patient satisfaction surveys have been used to measure outcome following lumbar fusion. Their usefulness resides in their insight into patient attitudes toward the treatment experience but is limited because of their inability to measure responsiveness and the lack of information on their reliability. 相似文献
92.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):647-652
Lumbar fusion may be associated with a high short-term cost, especially if instrumentation is placed; however, there appear to be long-term economic benefits associated with lumbar fusion including resumption of employment. To describe the economic impact of lumbar fusion for degenerative disease adequately, it is important to define the patient population treated with fusion and to compare efficacy as well as the costs of other treatment alternatives. Any such analysis should include both short- and long-term costs and benefits. 相似文献
93.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):707-715
In summary, there is no meaningful evidence in the medical literature that the use of epidural injections is of any long-term value in the treatment of patients with chronic low-back pain. The literature does indicate that the use of lumbar epidural injections can provide short-term relief in selected patients with chronic low-back pain. There is evidence that suggests that facet joint injections can be used to predict outcome after RF ablation of a facet joint. The predictive ability of facet joint injections does not appear to apply to lumbar fusion surgery. No evidence exists to support the effectiveness of facet injections in the treatment of patients with chronic low-back pain. There is conflicting evidence suggesting that the use of local TPIs can be effective for the short-term relief of low-back pain. There are no data to suggest that TPIs with either steroids or anesthetics alone provide lasting benefit for patients suffering from chronic low-back pain. 相似文献
94.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):653-657
The assessment of fusion status with static plain radiography is accurate in approximately two thirds of patients treated with lumbar fusion when the radiographic results are compared with surgical exploration findings. Therefore, static plain radiography is not recommended as a stand-alone modality following lumbar fusion procedures. The addition of lateral flexion-extension radiography may improve accuracy because the lack of motion between fused lumbar segments on lateral views is highly suggestive of a solid fusion. Some degree of motion between segments may be present even when the spine has fused. The amount of motion allowable across fused segments is not clear, and the role of internal fixation in limiting motion has also not been adequately addressed. The addition of multiplanar CT scanning results in the detection of pseudarthrosis in some patients in whom fusion has been deemed successful based on plain radiographic criteria. Therefore, CT scanning may be more accurate in the determination of fusion status than plain radiography; however, a rigorous comparison of modern CT scanning and surgical exploration has not been performed. It appears that RSA is exquisitely sensitive for the detection of motion between vertebral bodies, and the loss of motion between treated vertebral segments does appear to indicate the presence of fusion. The modality, however, is invasive and not widely available. Furthermore, the only 相似文献
95.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):658-661
At the present time, there is no Class I or II medical evidence to indicate that the appearance of a radiographic fusion is significantly associated with improved functional outcomes. The majority of Class III medical evidence does suggest that successful radiographic fusion is associated with improved clinical outcomes. It is widely acknowledged that this relationship is not perfect. 相似文献
96.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):670-672
Class I medical evidence exists in support of the use of lumbar fusion as a treatment standard for carefully selected patients with low-back pain intractable to the best medical management. There is Class III medical evidence that suggests that a course of intensive cognitive and physical therapy may be an efficacious treatment option for the treatment of patients with chronic disabling low-back pain. 相似文献
97.
Resnick DK Choudhri TF Dailey AT Groff MW Khoo L Matz PG Mummaneni P Watters WC Wang J Walters BC Hadley MN;American Association of Neurological Surgeons/Congress of Neurological Surgeons 《Journal of neurosurgery. Spine》2005,2(6):686-691
Based on the medical evidence derived from the scientific literature on this topic, there does not appear to be evidence to support the hypothesis that fusion (with or without instrumentation) provides any benefit over decompression alone in the treatment of lumbar stenosis in patients in whom there is no evidence of preoperative deformity or instability. A single report provides Class II medical evidence and several papers provide Class III medical evidence suggesting that the addition of fusion to decompression in patients with lumbar stenosis and instability evidenced by movement on preoperative flexion-extension radiographs does improve outcome. There are also reports (Class III medical evidence) indicating that patients with lumbar stenosis, without deformity or instability, treated with wide decompression or facetectomy may suffer iatrogenic lumbar instability. Fusion in these patients may improve outcome. There is conflicting Class III medical evidence regarding the application of instrumentation in addition to PLF in patients treated for lumbar stenosis without deformity or preoperative instability. 相似文献
98.
Contrary to popular views, pralidoxime chloride, a positively charged oxime and a drug used to treat poisoning from organophosphorus insecticides, penetrates the red cell membrane. Two other therapeutically related drugs that have similar dissociation constants and chemical function groupings penetrate to negligible extents. Pralidoxime chloride did not bind to either red cell stroma or hemoglobin. The rate of entry into red cells by pralidoxime chloride did not change when the pH of blood was changed by ± 0.6 pH unit. Since the rate of entry of pralidoxime chloride into red cells from plasma was identical to the rate at which oxime passed from red cells into plasma, the process was likely due to simple diffusion. In addition, the fraction of pralidoxime chloride entering the red cells was independent of drug concentration. The penetration was not affected by active transport inhibitors, such as ouabain or N-methyl maleimide. The selective penetration could not be related to lipid solubility. 相似文献
99.
E Lindh K L Chua A Kataoka P Bistoletti D Groff A Hjerpe 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》1992,100(4):301-308
A previously presented method for the detection and typing of human papillomavirus (HPV) DNA has been modified for the simultaneous analysis of HPV types 6, 11, 16, 18, 31, 33 and 35. The method has two steps, where a dot blot test is used to exclude cases that do not hybridize with HPV-DNA. The remaining cases are then analysed by a Southern blot procedure, using a mixture of subgenomic probes for the simple and accurate analysis of HPV types. When the procedure was used for the analysis of clinical samples, patient groups at varying risk were found to differ with regard to the prevalence of HPV infections. Thus, the virus was detected in only 8.8% of otherwise healthy young women - i.e. women without clinical signs of HPV-related disease - as compared to 48% of women who also had cervical intraepithelial neoplasia (CIN). A similarly high prevalence was found in patients in whom CIN persisted (42%) as compared to those in whom the morphological lesion regressed to normal (8%). 相似文献
100.