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991.
992.
Giuseppe Sanguineti MD Matthew L. Cavey Eugene J. Endres Paola Franzone Salvina Barra Brent C. Parker Michela Marcenaro Martin Colman Stefano Agostinelli Franca Foppiano Vito Vitale 《Strahlentherapie und Onkologie》2006,182(9):543-549
PURPOSE: To compare late rectal toxicity rates after three-dimensional conformal radiotherapy to the prostate alone (P-3D-CRT) and whole-pelvis intensity-modulated radiotherapy along with a prostate boost (WP-IMRT/PB) to the same nominal total dose to the prostate. PATIENTS AND METHODS: 68 patients treated with conformal radiotherapy to the prostate only to 76 Gy at the National Institute for Cancer Research, Genoa, Italy, represented the first group (P-3D-CRT). The second group consisted of 45 patients treated at the University of Texas Medical Branch (UTMB), Galveston, TX, USA, with IMRT covering the pelvic nodes and seminal vesicles to 54 Gy at 1.8 Gy per fraction and the prostate to 60 Gy in the same 30 fractions. A separate phase boosted the prostate to 76 Gy (WP-IMRT/PB). Major aspects of planning were remarkably similar at both institutions leaving the inclusion or not of pelvic nodes as the main treatment-related difference between the two groups. Late rectal toxicity was prospectively scored according to the RTOG scale. All patients have a 12-month minimum follow-up, and mean follow-up, similar in both groups, is 25.9 months (SD [standard deviation]: 8.4 months). RESULTS: At 2 years, the estimated cumulative incidence of grade 2 late rectal toxicity is 6%+/-4% for WP-IMRT/PB and 21.2%+/-6% for P-3D-CRT (p=0.06). The difference became significant (HR [hazard ratio]=0.1, 95% CI [confidence interval]: 0.0-0.6; p=0.01) at multivariate analysis. None of the patients developed grade 3+ toxicity. CONCLUSION: Despite the larger treated volume, WP-IMRT/PB allows more rectal sparing than P-3D-CRT. 相似文献
993.
Hepatitis C Virus Heteroduplex Tracking Assay for Genotype Determination Reveals Diverging Genotype 2 Isolates in Italian Hemodialysis Patients 总被引:3,自引:2,他引:1
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994.
Claudio Pasquali Domenico Rubello Cosimo Sperti Piero Gasparoni Guido Liessi Franca Chierichetti Giorgio Ferlin Sergio Pedrazzoli 《World journal of surgery》1998,22(6):588-592
n
= 13). Tumor FDG uptake was increased in the primary lesion of all eight aggressive NETs; the tracer was shown also in lymph
nodes, liver metastases, or both in five of six of them (83%). In four cases, additional unknown tumor sites undetected by
CT scan were identified. A slight positivity was found in only one of eight cases with a slow-growing NET. The overall octreotide
scintiscan sensitivity was 85%, but in the aggressive NETs it failed to detect the primary lesion in two of seven cases. Uptake
of the tracer in some but not all tumor lesions in the same patient was seen by both FDG-PET and octreotide scintiscans. From
our limited experience
18
F-FDG PET seems to be useful for identifying NETs characterized by rapid growth or aggressive behavior. Uptake of the FDG
tracer by the tumor may be related to a worse prognosis. Despite the heterogeneity of tracer uptake in the various lesions
of NETs with multiple tumor sites, FDG-PET was able to detect unsuspected distant metastases, contributing to better staging
of advanced disease. 相似文献
995.
Y. Liu P. Saccucci H. Qi H. C. Wu F. Zhao Y. Dai N. Bottini F. Gloria-Bottini 《The Journal of asthma》2006,43(3):203-206
We have studied a sample of 120 asthmatic patients and 116 healthy control subjects from the Chinese Han population. Three polymorphic sites: ADA1, ADA2, and ADA6, within the ADA gene have been examined. The proportion of carriers of *2 allele at locus ADA1 is drastically reduced in asthmatics as compared to controls. There is an epistatic interaction of ADA2 on the ADA1 site characterized by a suppressive effect by the *2 allele of ADA2 on the protective effect exerted by the *2 allele of ADA1 site on susceptibility to asthma. Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA1 and ADA2 sites. 相似文献
996.
Bosetti C Levi F Boffetta P Lucchini F Negri E La Vecchia C 《Hepatology (Baltimore, Md.)》2008,48(1):137-145
Upward trends in mortality from hepatocellular carcinoma (HCC) were recently reported in the United States and Japan. Comprehensive analyses of most recent data for European countries are not available. Age-standardized (world standard) HCC rates per 100,000 (at all ages, at age 20-44, and age 45-59 years) were computed for 23 European countries over the period 1980-2004 using data from the World Health Organization. Joinpoint regression analysis was used to identify significant changes in trends, and annual percent change were computed. Male overall mortality from HCC increased in Austria, Germany, Switzerland, and other western countries, while it significantly decreased over recent years in countries such as France and Italy, which had large upward trends until the mid-1990s. In the early 2000s, among countries allowing distinction between HCC and other liver cancers, the highest HCC rates in men were in France (6.8/100,000), Italy (6.7), and Switzerland (5.9), whereas the lowest ones were in Norway (1.0), Ireland (0.8), and Sweden (0.7). In women, a slight increase in overall HCC mortality was observed in Spain and Switzerland, while mortality decreased in several other European countries, particularly since the mid-1990s. In the early 2000s, female HCC mortality rates were highest in Italy (1.9/100,000), Switzerland (1.8), and Spain (1.5) and lowest in Greece, Ireland, and Sweden (0.3). In most countries, trends at age 45-59 years were consistent with overall ones, whereas they were more favorable at age 20-44 years in both sexes. CONCLUSION: HCC mortality remains largely variable across Europe. Favorable trends were observed in several European countries mainly over the last decade, particularly in women and in young adults. 相似文献
997.
Michele Emdin Aldo Clerico Francesco Clemenza Marcello Galvani Roberto Latini Serge Masson Paolo Mulè Mauro Panteghini Roberto Valle Martina Zaninotto Antonello Ganau Rita Mariotti Massimo Volpe Nadia Aspromonte Giuseppe Cacciatore Piero Cappelletti Antonio L'Abbate Federico Miglio Filippo Ottani Franca Pagani Claudio Passino Mario Plebani Riccardo Sarzani Giancarlo Zucchelli 《Italian heart journal. Supplement》2005,6(5):308-325
998.
Gallbladder contraction and its relationship to interdigestive duodenal motor activity in normal human subjects 总被引:3,自引:0,他引:3
Leonardo Marzio MD Matteo Neri MD Fabrizio Capone MD Franca Di Felice MD Carlo De Angelis MD Andrea Mezzetti MD Franco Cuccurullo MD 《Digestive diseases and sciences》1988,33(5):540-544
Gallbladder volume and interdigestive gastric and duodenal motor activity were evaluated simultaneously in 12 normal subjects. After overnight fasting, gallbladder volume was monitored every 4 min in each subject by means of real-time ultrasonography, and gastroduodenal motor activity was measured by means of a probe consisting of three polyvinyl catheters with one side opening for each catheter, placed 15 cm apart and constantly perfused with deionized water. Real-time ultrasonography and intestinal manometry were performed by different investigators and continued until at least two consecutive spontaneous phase III activities of migrating motor complexes were observed. The results show a cyclic variation of gallbladder volume, which reached its minimum value before the end of phase II in the proximal duodenum and its maximum in early phase II, 25 min after the beginning of phase III. These results suggest that there is a relationship between the cyclic gallbladder volume changes, which occur during fasting in humans, and with the various phases of duodenal migrating motor complex. 相似文献
999.
Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution 总被引:9,自引:0,他引:9
Gammaitoni L Bruno S Sanavio F Gunetti M Kollet O Cavalloni G Falda M Fagioli F Lapidot T Aglietta M Piacibello W 《Experimental hematology》2003,31(3):261-270
OBJECTIVE: Ex vivo expansion of human hemopoietic stem cells (HSC) is an important issue in transplantation and gene therapy. Encouraging results have been obtained with cord blood, where extensive amplification of primitive progenitors was observed. So far, this goal has been elusive with adult cells, in which amplification of committed and mature cells, but not of long-term repopulating cells, has been described. METHODS: Adult normal bone marrow (BM) and mobilized peripheral blood (MPB) CD34(+) cells were cultured in a stroma-free liquid culture in the presence of Flt-3 ligand (FL), thrombopoietin (TPO), stem cell factor (SCF), interleukin-6 (IL-6), or interleukin-3 (IL-3). Suitable aliquots of cells were used to monitor cell production, clonogenic activity, LTC-IC output, and in vivo repopulating capacity. RESULTS: Here we report that BM and MPB HSC can be cultured in the presence of FL, TPO, SCF, and IL-6 for up to 10 weeks, during which time they proliferate and produce large numbers of committed progenitors (up to 3000-fold). Primitive NOD/SCID mouse repopulating stem cells (SRC) are expanded sixfold after 3 weeks (by limiting dilution studies) and retain the ability to repopulate secondary NOD/SCID mice after serial transplants. Substitution of IL-6 with IL-3 leads to a similarly high production of committed and differentiated cells but only to a transient (1 week) expansion of SRC(s), which do not possess secondary repopulation capacity. CONCLUSION: We report evidence to show that under appropriate culture conditions, adult human SRC can also be induced to expand with limited differentiation. 相似文献
1000.
c-kit Is Expressed in Soft Tissue Sarcoma of Neuroectodermic Origin and Its Ligand Prevents Apoptosis of Neoplastic Cells 总被引:3,自引:1,他引:3