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Diosque P Padilla AM Cimino RO Cardozo RM Negrette OS Marco JD Zacca R Meza C Juarez A Rojo H Rey R Corrales RM Nasser JR Basombrío MA 《The American journal of tropical medicine and hygiene》2004,71(5):590-593
We studied the seroprevalence of antibodies against Trypanosoma cruzi in the human population along with domiciliary infestation by triatomine bugs in an area endemic for Chagas disease in the Chaco Province of Argentina. In addition, we carried out parasitologic surveys in patients, dogs, wild mammals, and vectors. The mean seroprevalence in humans was 27.81% (109 of 392) and 24.14% (63 of 261) in 1-15-year-old children. The minimum domiciliary infestation rate was 13.33%, with certain areas reaching 53.85%. The prevalence was 15.09% (16 of 106) in dogs and 35.71% (10 of 28) in opossums. Infection with T. cruzi was detected in 30.10% (59 of 196) of the Triatoma infestans tested. Compared with nationwide studies, our data suggest that 1) there are zones requiring immediate sanitary action, and 2) nationwide estimates are based on very heterogeneous epidemiologic situations. This heterogeneity emphasizes the importance of in-depth studies of restricted areas to provide additional information for a better understanding of the present status of Chagas disease in Argentina. 相似文献
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Mateos MV Hernández JM Hernández MT Gutiérrez NC Palomera L Fuertes M Garcia-Sanchez P Lahuerta JJ de la Rubia J Terol MJ Sureda A Bargay J Ribas P Alegre A de Arriba F Oriol A Carrera D García-Laraña J García-Sanz R Bladé J Prósper F Mateo G Esseltine DL van de Velde H San Miguel JF 《Haematologica》2008,93(4):560-565
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Blood donors are routinely screened for hepatitis C virus infection. Some individuals have weak or restricted virus-specific antibody responses, and are classed as indeterminate. Such donors are almost always negative for viral RNA in blood. We postulated that previous transient virus exposure might account for some of these cases. With sensitive ex-vivo analyses of T-cell responses, we identified virus-specific responses in 15 of 30 indeterminate blood donors tested, compared with none in controls (p=0.0013). Additionally, these responses were typically focused on core-derived peptides. These findings suggest previous exposure to the virus in many indeterminate blood donors. 相似文献
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Martínez E Milinkovic A de Lazzari E Ravasi G Blanco JL Larrousse M Mallolas J García F Miró JM Gatell JM 《Lancet》2004,364(9428):65-67
The rise in didanosine concentrations in plasma when given with tenofovir raises concern for a high risk of toxic effects. Recommendations to reduce didanosine dose have been issued, but only for adults weighing more than 60 kg. We reviewed cases of pancreatitis in patients receiving didanosine plus tenofovir, didanosine alone, and tenofovir alone to assess the incidence of and risk factors for pancreatitis. Between Aug 1, 2001, and Nov 30, 2003, five of 185 (2.7%) patients receiving didanosine plus tenofovir, one of 182 (0.5%) on didanosine without tenofovir, and none of 208 on tenofovir without didanosine developed pancreatitis (p=0.016). Co-administration of both drugs versus each of them individually was an independent risk factor for pancreatitis (crude hazard ratio 10.666, 95% CI 1.246-91.294, p=0.031). These results suggest that the risk of pancreatitis is heightened when didanosine and tenofovir are given together. 相似文献
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Ritter C Andrades M Moreira JC Dal-Pizzol F Hussain SN 《American journal of respiratory and critical care medicine》2003,167(3):474; author reply 474-474; author reply 475
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José Wellington Alves dos Santos Fabiani Palagi Machado Felipe Schaich Douglas Zaione Nascimento Tiago Teixeira Simon Luis Fernando Cibin Keli Cristina Mann Vinícius André Guerra Mateus Correa Marcos Ferreira Gazzoni Marta Pires da Rocha Melissa Daubermann Falster Ronaldo Manfredini Vassoler 《Respiratory Medicine Extra》2007,3(4):186-188
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