全文获取类型
收费全文 | 3239篇 |
免费 | 168篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 47篇 |
妇产科学 | 86篇 |
基础医学 | 384篇 |
口腔科学 | 100篇 |
临床医学 | 249篇 |
内科学 | 716篇 |
皮肤病学 | 107篇 |
神经病学 | 489篇 |
特种医学 | 107篇 |
外科学 | 543篇 |
综合类 | 8篇 |
预防医学 | 107篇 |
眼科学 | 29篇 |
药学 | 173篇 |
中国医学 | 3篇 |
肿瘤学 | 267篇 |
出版年
2024年 | 6篇 |
2023年 | 27篇 |
2022年 | 79篇 |
2021年 | 134篇 |
2020年 | 81篇 |
2019年 | 83篇 |
2018年 | 118篇 |
2017年 | 101篇 |
2016年 | 117篇 |
2015年 | 110篇 |
2014年 | 172篇 |
2013年 | 203篇 |
2012年 | 281篇 |
2011年 | 284篇 |
2010年 | 169篇 |
2009年 | 142篇 |
2008年 | 245篇 |
2007年 | 208篇 |
2006年 | 176篇 |
2005年 | 186篇 |
2004年 | 175篇 |
2003年 | 164篇 |
2002年 | 116篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 14篇 |
1998年 | 10篇 |
1997年 | 4篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1985年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有3435条查询结果,搜索用时 0 毫秒
71.
Filippo Pietrantonio Fotios Loupakis Giovanni Randon Alessandra Raimondi Massimiliano Salati Dario Trapani Filippo Pagani Ilaria Depetris Giulia Maddalena Federica Morano Salvatore Corallo Michele Prisciandaro Francesca Corti Vincenzo Guarini Alessandro Bocconi Antonio Marra Carmen Belli Andrea Spallanzani Matteo Fassan Sara Lonardi Giuseppe Curigliano Giovanni Fucà Maria Di Bartolomeo Filippo de Braud 《The oncologist》2020,25(9):803-809
72.
Arturo Ciccullo Gianmaria Baldin Vanni Borghi Filippo Lagi Alessandra Latini Gabriella dEttorre Letizia Oreni Paolo Fusco Amedeo Capetti Massimiliano Fabbiani Andrea Giacomelli Alessandro Grimaldi Giordano Madeddu Gaetana Sterrantino Cristina Mussini Simona Di Giambenedetto 《Viruses》2022,14(1)
Dolutegravir (DTG) is currently one of the most used Integrase inhibitors (INI) in antiretroviral therapies (ARV) in both naïve and experienced people living with HIV (PLWHIV). We analyzed a multicenter cohort of PLWHIV, both naïve and experienced, starting an ARV including DTG. We enrolled 3775 PLWHIV: 2763 (73.2%) were males, with a median age of 50 years. During 9890.7 PYFU, we observed 930 discontinuations (9.4 per 100 PYFU). Estimated probabilities of maintaining DTG at three and five years were 75.1% and 67.2%, respectively. Treatment-naïve pts showed a lower probability of maintaining DTG at three and five years compared to treatment-experienced PLWHIV (log-rank p < 0.001). At a multivariate analysis, a longer time of virological suppression (aHR 0.994, p < 0.001) and having experienced a previous virological failure (aHR 0.788, p = 0.016) resulted protective against DTG discontinuation. Most discontinuations (84.0%) happened within the first 12 months of DTG initiation, in particular, 92.2% of discontinuations due to neuropsychiatric toxicity were observed in the first year. Our data confirm the overall good tolerability of DTG in clinical practice, with a low rate of discontinuations. CNS toxicity resulted the main reason for DTG discontinuation, with most related interruptions happening in the first year from DTG introduction. 相似文献
73.
74.
Marco Cerrano Massimiliano Bonifacio Matteo Olivi Antonio Curti Michele Malagola Michelina Dargenio Anna Maria Scattolin Cristina Papayannidis Fabio Forghieri Carmela Gurrieri Ilaria Tanasi Patrizia Zappasodi Roberta La Starza Nicola Stefano Fracchiolla Patrizia Chiusolo Luisa Giaccone Maria Ilaria Del Principe Fabio Giglio Marzia Defina Claudio Favre Carmelo Rizzari Barbara Castella Giovanni Pizzolo Felicetto Ferrara Sabina Chiaretti Robin Fo 《Haematologica》2022,107(4):996
75.
Michelangelo Mancuso Daniele Orsucci Corrado Angelini Enrico Bertini Valerio Carelli Giacomo Pietro Comi Maria Alice Donati Antonio Federico Carlo Minetti Maurizio Moggio Tiziana Mongini Filippo Maria Santorelli Serenella Servidei Paola Tonin Antonio Toscano Claudio Bruno Luca Bello Elena Caldarazzo Ienco Elena Cardaioli Michela Catteruccia Paola Da Pozzo Massimiliano Filosto Costanza Lamperti Isabella Moroni Olimpia Musumeci Elena Pegoraro Dario Ronchi Donato Sauchelli Mauro Scarpelli Monica Sciacco Maria Lucia Valentino Liliana Vercelli Massimo Zeviani Gabriele Siciliano 《Journal of neurology》2015,262(5):1301-1309
76.
BACKGROUND: In a cross-sectional case-control study conducted in northern Italy, 64 former aluminium dust-exposed workers were compared with 32 unexposed controls from other companies matched for age, professional training, economic status, educational and clinical features. The findings lead the authors to suggest a possible role of the inhalation of aluminium dust in pre-clinical mild cognitive disorder which might prelude Alzheimer's disease (AD) or AD-like neurological deterioration. METHODS: The investigation involved a standardised occupational and medical history with particular attention to exposure and symptoms, assessments of neurotoxic metals in serum: aluminium (Al-s), copper (Cu-s) and zinc (Zn-s), and in blood: manganese (Mn-b), lead (Pb-b) and iron (Fe-b). Cognitive functions were assessed by the Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT) and auditory evoked Event-Related Potential (ERP-P300). To detect early signs of mild cognitive impairment (MCI), the time required to solve the MMSE (MMSE-time) and CDT (CDT-time) was also measured. RESULTS: Significantly higher internal doses of Al-s and Fe-b were found in the ex-employees compared to the control group. The neuropsychological tests showed a significant difference in the latency of P300, MMSE score, MMSE-time, CDT score and CDT-time between the exposed and the control population. P300 latency was found to correlate positively with Al-s and MMSE-time. Al-s has significant effects on all tests: a negative relationship was observed between internal Al concentrations, MMSE score and CDT score; a positive relationship was found between internal Al concentrations, MMSE-time and CDT-time. All the potential confounders such as age, height, weight, blood pressure, schooling years, alcohol, coffee consumption and smoking habit were taken into account. CONCLUSIONS: These findings suggest a role of aluminium in early neurotoxic effects that can be detected at a pre-clinical stage by P300, MMSE, MMSE-time, CDT-time and CDT score, considering a 10 micrograms/l cut-off level of serum aluminium, in aluminium foundry workers with concomitant high blood levels of iron. The authors raise the question whether pre-clinical detection of aluminium neurotoxicity and consequent early treatment might help to prevent or retard the onset of AD or AD-like pathologies. 相似文献
77.
Andrzej Klimpel Anna Timofiejczuk Jarosaw Kaczmarczyk Krzysztof Herbu Massimiliano Pedot 《Materials》2022,15(4)
Refineries piping installation systems are designed, fabricated, and operated to assure very high levels of quality and structural integrity, to provide very high resilience to catastrophic events like earthquakes, explosions, or fires, which could induce catastrophic damage of piping systems due to collapse of nearby structures as towers, bridges, poles, walkways, vessels, etc. To evaluate the catastrophic impact loading resilience to failure of MMA (Manual Metal Arc Welding), GMA (Gas Metal Arc Welding), SSA (Self-shielded Arc Welding), and LASER+GMA of modern API 5L X80 pipes butt welded joints used for piping installation systems of refineries, the new, original technique of the quantitative and qualitative evaluation of impact loading resilience of butt welded joints of pipes was developed. The high-quality butt welded joints were impact loaded by the freely dropping 3000 kg mass hammer of the die forging hammer apparatus. The impact loading energy needed to exceed the yield strength of the extreme zone of welded joints and to induce catastrophic fracture of butt welded joints of API 5L X80 pipes was calculated using FEM (Finite Element Method) modeling of the impact loading process of tested butt welded joints of pipes. Results of the FEM modeling of impact loading technique of butt welded joints of piping systems indicate that it is a useful tool to provide valuable data for experimental impact loading tests of welded joints of pipes, decreasing the time and cost of the experiments. The developed impact loading technique of butt welded joints of pipes to simulate the catastrophic events in refinery piping systems and evaluate the resilience of the butt welded joints of pipes to catastrophic failure proved to be very efficient and accurate. Experiments of impact loading indicated that all specimens of butt welded joints API 5L X80 steel pipes are resilient to failure (cracks) in the extreme stressed/strained areas, above yield and tensile strength of the weld metals, no cracks or tears appeared in the extreme stressed/strained areas of the edges of the pipes, proving the very high quality of API 5L X80 steel pipes. 相似文献
78.
Chiara Lestuzzi Davide Stolfo Antonino De Paoli Alberto Banzato Angela Buonadonna Ettore Bidoli Lucia Tartuferi Elda Viel Giulia De Angelis Sara Lonardi Roberto Innocente Massimiliano Berretta Francesca Bergamo Alessandra Guglielmi Gianfranco Sinagra Joerg Herrmann 《The oncologist》2022,27(2):e158
BackgroundPhysical activity may increase the risk of cardiotoxicity (myocardial ischemia, major arrhythmias) of 5-Fluorouracil, but this risk has never been investigated for its prodrug capecitabine.Patients and MethodsOne hundred and ninety-two consecutive patients undergoing capecitabine chemotherapy from December 1, 2010 through July 31, 2016 were prospectively evaluated. The baseline evaluation included electrocardiography (ECG) and echocardiography (2DE); a follow-up evaluation, including ECG and exercise stress testing (2DE in case of ECG abnormalities), was done after ≥10 days of treatment. Cardiotoxicity was suspected from ischemic ECG changes, new kinetic abnormalities at 2DE, Lown classification ≥2 ventricular arrhythmia, symptomatic arrhythmias, or positive stress test, and confirmed by a negative stress test after capecitabine washout.ResultsCardiotoxicity was diagnosed in 32 patients (16.7%): six at rest and 26 during exercise. All 32 patients had ECG abnormalities: ST-segment changes (24 patients), negative T-waves (2) and/or arrhythmias: ventricular arrhythmias (14 cases), supraventricular tachycardia (2), complete heart block (1). Eight patients had typical symptoms, 6 had atypical symptoms, 1 had syncope, 17 (53%) were asymptomatic. Cardiotoxicity was more common in patients with atypical symptoms during daily life (OR = 15.7) and in those on a therapeutic schedule of 5 days/week (OR = 9.44).ConclusionCapecitabine cardiotoxicity is frequent, and often elicited by physical effort. Oncologists, cardiologists, and general practitioners should be aware of this risk. Active cardiotoxicity surveillance with ECG (and echocardiogram and/or stress testing in suspected cases) during therapy is recommended.Clinical Trials registration numberCRO-2010-17. 相似文献
79.