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101.
Recently, Eve et al. (2007) reported that the expression of TP53 (NM_000546) was increased by 2.1-fold in whole spinal cord and 2.7-fold in the ventral horn of amyotrophic lateral sclerosis (ALS) patients. Based on this particular observation, we decided to evaluate whether the TP53 Arg72Pro polymorphism (rs1042522) (C215G) was implicated in the etiopathology of sporadic amyotrophic lateral sclerosis (SALS). Therefore, we genotyped 394 Turkish SALS patients and 439 matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We did not find any association between overall SALS patients with the TP53 Arg72Pro polymorphism and controls (χ2 = 2.674; p = 0.263). Consequently the TP53 Arg72Pro polymorphism was not associated with SALS. 相似文献
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Kabaalioglu A Ceken K Alimoglu E Saba R Cubuk M Arslan G Apaydin A 《AJR. American journal of roentgenology》2007,189(4):824-828
OBJECTIVE: The purpose of our study was to describe the initial and long-term imaging findings in hepatobiliary fascioliasis. CONCLUSION: Most patients with fascioliasis have typical hepatobiliary imaging findings. It is important to know that residual fibrotic or necrotic foci may remain for years after cure. Long-term complications are rare in fascioliasis, and malignancy or cirrhosis related to the disease has not been observed. 相似文献
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Dede F Ones T Caliskan B Civen H Erdil TY Inanir S Tuglular ZS Yegen C Akoglu E Turoglu HT 《Annals of nuclear medicine》2007,21(10):603-606
Urine leak in the early postoperative period following renal transplantation is a serious complication requiring early identification
and aggressive intervention, which significantly reduces the morbidity and mortality. Renal transplant scintigraphy is a noninvasive
method to evaluate the perfusion and function of a transplanted kidney and urinary drainage including urine leak. Here, we
reported two cases in which the standard transplant renogram failed to demonstrate urine leak. The cases were referred for
a diethylenetriaminepentaacetic acid renogram following the transplantation to evaluate the cause of symptoms or elevated
serum creatinine level. In both the cases, urine leak was successfully detected following simple maneuvers such as diuretic
administration or Foley catheter irrigation. Renal transplant scintigraphy is an effective and safe technique and the use
of these simple maneuvers can enhance the diagnostic sensitivity of the transplant renogram in the detection of urine leak. 相似文献
105.
Meral Akcay Ciblak Mustafa Hasoksuz Vanessa Escuret Martine Valette Fadime Gul Huseyin Yilmaz Nuri Turan Emel Bozkaya Selim Badur 《Journal of medical virology》2009,81(9):1645-1651
Monitoring the activity of influenza viruses is important for establishing the circulating types and for detection of the emergence of novel sub‐types and antiviral resistant strains. This is the first report from Turkey on the surveillance and oseltamivir resistance of influenza viruses in 2007–2008. Five hundred twenty‐four nasal swabs were tested from different geographical regions in Turkey during November 2007–April 2008. One hundred sixty‐three (31%) samples were positive for influenza viruses of which 111 (68%) were influenza A, 52 (31%) influenza B using an immuno‐capture ELISA. Forty isolates were selected at random from influenza A positive samples and grown in MDCK cell cultures. The supernatant of the cell cultures was used for RNA extraction followed by RT‐PCR to detect the sub‐types. Sub‐typing revealed all samples as A/H1N1. The N1 gene segment of 30 A/H1N1 samples was sequenced in part, from the 201st to 365th residue, which included the critical region for oseltamivir resistance. Then resulting sequences were analyzed with oseltamivir sensitive and resistant strains obtained from National Center for Biotechnology Information (NCBI) GenBank by CLC Main Workbench Software. H275Y (H274Y according to N2 numbering) mutation, which is known to confer resistance to oseltamivir, was detected in 6 out of 30 (20%) H1N1 isolates from four cities (Istanbul, Bursa, Ankara, and Izmir). The D354G mutation was observed in all oseltamivir resistant H1N1 isolates but not in the oseltamivir sensitive isolates. Assay of neuraminidase activity revealed that these isolates were resistant to oseltamivir, but sensitive to zanamivir. J. Med. Virol. 81:1645–1651, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
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Emekli-Alturfan E Demir G Kasikci E Tunali-Akbay T Pisiriciler R Caliskan E Yarat A 《The Tohoku journal of experimental medicine》2008,214(2):89-96
Saliva plays an important role in the protection of oral cavity and alterations in either salivary flow rate or protein composition may have dramatic effects on oral health. Prevention and management of oral complications of cancer and cancer therapy will improve oral function and quality of life, and reduce morbidity and the cost of care. The aim of this study was to investigate the saliva of patients with breast cancer biochemically and cytologically and compare with healthy controls. Accordingly, lipid peroxidation (LPO), total protein, salivary flow rate, and pH levels were measured in the saliva samples obtained from 20 breast cancer patients and 11 healthy individuals. Tissue factor (TF) is a major regulator of normal hemostasis and thrombosis, and TF activity of saliva samples was evaluated. Under the conditions used, patients with breast cancer present a significant reduction in total protein, pH and LPO levels. Salivary TF activity was higher in breast cancer patients than that in control subjects, but the degree of increase was not statistically significant. In addition, the analysis of saliva samples by SDS polyacrylamide gel electrophoresis showed the retarded mobility of the 66-kDa proteins and the increased proteins of about 36 kDa in the patient group. Some patients with breast cancer had increased number of leucocytes. Importantly, dysplastic cells and yeast cells were detected only in saliva samples of cancer patients. Decreased salivary LPO may be considered as a risk factor for breast cancer. 相似文献
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Subodh Verma MD Hani Sabbour MD Naji Alamuddin MD Fatheya Alawadi MD Hessa Alkandari MD Wael Almahmeed MD Samir H. Assaad-Khalil MD Jihad Haddad MD Landman Lombard MBChB Rayaz A. Malik MBChB Emel Mashaki Ceyhan PharmD Preethy Prasad PhD Gamze Tombak MD Sam Salek PhD 《Diabetes, obesity & metabolism》2023,25(6):1444-1452