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Delivery of normal twins following the intracytoplasmic injection of spermatozoa from a patient with 47,XXY Klinefelter's syndrome 总被引:4,自引:9,他引:4
Bourne H; Stern K; Clarke G; Pertile M; Speirs A; Baker HW 《Human reproduction (Oxford, England)》1997,12(11):2447-2450
Klinefelter's syndrome is a disorder of gonadal development and typically
reveals a 47,XXY karyotype although mosaic forms also occur. Azoospermia is
a common feature, but severe oligozoospermia and fertility have been
reported. In this study, we have used intracytoplasmic sperm injection
(ICSI) to achieve a live twin birth using spermatozoa from a 47,XXY man who
has occasional spermatozoa present in the ejaculate. Spermatozoa were
obtained from multiple ejaculates and frozen prior to commencing IVF
treatment. Nine good quality embryos developed from the injection of 13
oocytes. All nine embryos were frozen. The initial transfer of two
frozen-thawed embryos was unsuccessful. In the following cycle, the
transfer of two additional frozen-thawed embryos resulted in the delivery
of normal, healthy male and female twins. Five embryos remain frozen. It
has generally been thought that the germ cells of 47,XXY men are unable to
proceed through meiosis. Any spermatozoa produced have been assumed to come
from a normal germ cell and therefore likely to have a normal karyotype.
However, recent evidence suggests that meiosis of 47,XXY germ cells may be
possible. Whether spermatozoa in these men arise from meiosis of 47,XXY
germ cells, or from germ cells which have attained a normal karyotype by
loss of an X chromosome, is unclear. Any risks in using spermatozoa from
these patients have not yet been established. Patients need to be advised
accordingly, and preimplantation or prenatal diagnosis should be
considered. A cautious approach to the treatment of these patients is
therefore warranted.
相似文献
55.
Pressure ulcers in trauma patients with suspected spine injury: a prospective cohort study with emphasis on device‐related pressure ulcers 下载免费PDF全文
Wietske HW Ham Lisette Schoonhoven Marieke J Schuurmans Luke PH Leenen 《International wound journal》2017,14(1):104-111
Of all patients in a hospital environment, trauma patients may be particularly at risk for developing (device‐related) pressure ulcers (PUs), because of their traumatic injuries, immobility, and exposure to immobilizing and medical devices. Studies on device‐related PUs are scarce. With this study, the incidence and characteristics of PUs and the proportion of PUs that are related to devices in adult trauma patients with suspected spinal injury were described. From January–December 2013, 254 trauma patients were visited every 2 days for skin assessment. The overall incidence of PUs was 28·3% (n = 72/254 patients). The incidence of device‐related PUs was 20·1% (n = 51), and 13% (n = 33) developed solely device‐related PUs. We observed 145 PUs in total of which 60·7% were related to devices (88/145). Device‐related PUs were detected 16 different locations on the front and back of the body. These results show that the incidence of PUs and the proportion of device‐related PUs is very high in trauma patients. 相似文献
56.
目的 骨唾液酸蛋白(Bone sialoprotein,简称BSP)是由成骨细胞分泌的一种非胶原蛋白质,反映骨转换和骨形成的指标。最近研究认为:血清BSP浓度可反映破骨细胞活性和骨吸收过程,也可能是一个骨吸收指标。本实验测定了血清BSP在人体内的生物变异性。方法 采用RIA 法测定了290例不同性别和年龄的正常人血清BSP的正常值,血清BSP的天-天变异性及24 h 生物周期。 结果 在儿童组血清BSP正常水平明显高于成人组,其最高值在新生儿期和青春期。绝经后妇女其血清浓度比绝经前妇女水平明显升高(P< 0.05)。血清BSP在每天同一时间的波动范围在 7.3% 至17.7% (平均11.7% )。24 h 内有一个明显的生物周期性变化,表现为峰值在凌晨4~8 时,然后逐渐下降直到午后14时为最低。其生物周期的最大波幅为±20% ,(平均血浓度为10.5 ng/m l)。结论 血清BSP反映了骨转换的生理变化与年龄有明显相关性,其血清水平24 h 内有一个明显的生物周期,而天与天之间变异性较小。 相似文献
57.
Written information material and availability of sexual health care for men experiencing sexual dysfunction after prostate cancer treatment: An evaluation of Dutch urology and radiotherapy departments 下载免费PDF全文
L.A. Grondhuis Palacios BSc E.M. Krouwel MD M. Duijn MD B.L. den Oudsten PhD M.E.M. den Ouden PhD H. Putter PhD R.C.M. Pelger MD PhD H.W. Elzevier MD PhD 《European journal of cancer care》2017,26(2)
Objective was to investigate content of written information material and availability of sexual health care for men experiencing sexual dysfunction (SD) after prostate cancer treatment. A cross‐sectional survey was conducted among Dutch urology and radiotherapy departments to evaluate information materials and availability of sexual health care. Out of 71 eligible departments, 34 urology and 15 radiotherapy departments participated in the survey (response rate 69.0%). Fifty‐nine brochures corresponding to 31 urology and 11 radiotherapy departments were analysed. In 88.1% of collected information material, sexual health was mentioned. Regarding extensiveness, 20.4% of the brochures contained extensive information, 50.8% moderate amount of information and 28.8% contained little or no information. Urology departments provided pre‐treatment nurse consultations more often than radiotherapy departments. Sexual counselling was more frequently provided by urology departments. Urology departments were more aware of adequate referral possibilities. Information material provided by Dutch urology and radiotherapy departments does not address treatment‐related SD routinely. Sexual health care is not available everywhere for men experiencing SD. Applying a standard regarding content of sexual health in information material is recommended as well as improved awareness of referral possibilities and enhanced provision of pre‐treatment nurse consultations for men experiencing SD after prostate cancer treatment. 相似文献
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Justus HW Jansen Olav P van der Jagt Bas J Punt Jan AN Verhaar Johannes PTM van Leeuwen Harrie Weinans Holger Jahr 《BMC musculoskeletal disorders》2010,11(1):188
Background
Although pulsed electromagnetic field (PEMF) stimulation may be clinically beneficial during fracture healing and for a wide range of bone disorders, there is still debate on its working mechanism. Mesenchymal stem cells are likely mediators facilitating the observed clinical effects of PEMF. Here, we performed in vitro experiments to investigate the effect of PEMF stimulation on human bone marrow-derived stromal cell (BMSC) metabolism and, specifically, whether PEMF can stimulate their osteogenic differentiation. 相似文献60.
陆金春等[1]所著的"中国118家实验室精液分析状况的调查"一文主要回顾了当前在中国采用的精液分析方法. 相似文献