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61.
Waltraud Hakenberg 《MedR Medizinrecht》2000,18(2):55-62
Ohne Zusammenfassung 相似文献
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Michaela Finsterbusch Waltraud C. Schrottmaier Julia B. Kral-Pointner Manuel Salzmann 《Platelets》2018,29(7):677-685
Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct engagement with different types of leukocytes. Indeed, increased platelet-leukocyte aggregates (PLAs) within the circulation and/or locally at the site of inflammation represent markers of many thrombo-inflammatory diseases, such as cardiovascular diseases, acute lung injury, renal and cerebral inflammation. Therefore, measurement of PLAs could provide an attractive and easily accessible prognostic and/or diagnostic tool for many diseases. To measure PLAs in different (patho-)physiological settings in human and animal models flow cytometric and microscopic approaches have been applied. These techniques represent complementary tools to study different aspects relating to the involvement of leukocyte subtypes and molecules, as well as location of PLAs within tissues, dynamics of their interactions and/or dynamic changes in leukocyte and platelet behaviour. This review summarises various approaches to measure and interpret PLAs and discusses potential experimental factors influencing platelet binding to leukocytes. Furthermore, we summarise insights gained from studies regarding the underlying mechanism of platelet-leukocyte interactions and discuss implications of these interactions in health and disease. 相似文献
64.
Ferdinand O. Bohmann Katharina Gruber Natalia Kurka Laurent M. Willems Eva Herrmann Richard du Mesnil de Rochemont Peter Scholz Heike Rai Philipp Zickler Michael Ertl Ansgar Berlis Sven Poli Annerose Mengel Peter Ringleb Simon Nagel Johannes Pfaff Frank A. Wollenweber Lars Kellert Moriz Herzberg Luzie Koehler Karl Georg Haeusler Anna Alegiani Charlotte Schubert Caspar Brekenfeld Christopher E. J. Doppler
zgür A. Onur Christoph Kabbasch Tanja Manser Helmuth Steinmetz Waltraud Pfeilschifter 《European journal of neurology》2022,29(1):138-148
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Elizabeth Lindley Ray James Gary Wright Elisheva Milo Melissa Goench Alois Gorke Ruth Hyde Jackie Ross Marisa Pegoraro James Tattersall Esperanza Vlez Richard Ward Maurice Harrington Diane Thomson Anne Murphy Gordon Farquhar Jean‐Yves De Vos Susan Hansen Gareth Murcutt Nic Hoenich Freddy Hardy Stanley Shaldon Hans Polaschegg Andr Stragier Franta Lopot Lenora Perkins Rosie Simmonds Christine Lansing Anthony Page John Agar Dick Cole John Sedgewick Lee Fischbach Waltraud Küntzle Stephen Sandroni 《Journal of Renal Care》2005,31(4):220-227
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Waltraud Leiss Marie Méan Andreas Limacher Marc Righini Kurt Jaeger Hans-Jürg Beer Joseph Osterwalder Beat Frauchiger Christian M. Matter Nils Kucher Anne Angelillo-Scherrer Jacques Cornuz Martin Banyai Bernhard L?mmle Marc Husmann Michael Egloff Markus Aschwanden Nicolas Rodondi Drahomir Aujesky 《Journal of general internal medicine》2015,30(1):17-24
67.
Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain 总被引:2,自引:0,他引:2
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Zöllner C Mousa SA Fischer O Rittner HL Shaqura M Brack A Shakibaei M Binder W Urban F Stein C Schäfer M 《The Journal of clinical investigation》2008,118(3):1065-1073
Although opioids are highly effective analgesics, they are also known to induce cellular adaptations resulting in tolerance. Experimental studies are often performed in the absence of painful tissue injury, which precludes extrapolation to the clinical situation. Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence of painful CFA-induced paw inflammation. In sensory neurons of these animals, internalization of mu-receptors was significantly increased and G protein coupling of mu-receptors as well as inhibition of cAMP accumulation were preserved. Opioid receptor trafficking and signaling were reduced, and tolerance was restored when endogenous opioid peptides in inflamed tissue were removed by antibodies or by depleting opioid-producing granulocytes, monocytes, and lymphocytes with cyclophosphamide (CTX). Our data indicate that the continuous availability of endogenous opioids in inflamed tissue increases recycling and preserves signaling of mu-receptors in sensory neurons, thereby counteracting the development of peripheral opioid tolerance. These findings infer that the use of peripherally acting opioids for the prolonged treatment of inflammatory pain associated with diseases such as chronic arthritis, inflammatory neuropathy, or cancer, is not necessarily accompanied by opioid tolerance. 相似文献
68.
ElizabethJ L Hanna L Walker D Milo E Koupatsiaris T De Vos JY Sedgewick J Pugh-Clarke K O'Kane F Treloar G Pegoraro M Marti A Muroma-Karttunen R Murcutt G Shaldon S Hoenich N Brooks D Pilley K Küntzle W Goovaerts T 《Journal of Renal Care》2006,32(4):214-220
The discussion was initiated by a paper on the influence of a pre-dialysis education programme on the mode of renal replacement therapy by Goovaerts et al (NDT 2005). Barriers to the uptake of self-care treatment modalities, including late referral, limited availability of treatment options, reimbursement, support from staff and families, the requirement for a helper and the length of the training programmes for home haemodialysis (HD) were discussed by 21 participants from 12 countries. The 'take-home' messages from the discussion were that to optimise the uptake of self-care modalities, renal units should try to ensure the all patients who are able to choose are fully informed before starting dialysis, even if they are referred to the unit very late. Offering a wide range of treatment options to new patients, and allowing (or encouraging) home HD without a helper, may also increase the number of patients who start and stay on a self-care modality. It should be possible to provide an acceptable level of training, without compromising on safety, within 3 weeks if the patient is confident with needling. 相似文献
69.
The effect of triterpenes and flavonoids on the activity of several hyaluronic acid-splitting enzymes was investigated. Studies showed that the inhibitory effect of the triterpenes glycyrrhizin and glycyrrhetinic acid is dependent on the source of hyaluronate lyase. Hyaluronate lyase from Streptococcus agalactiae (Hyal B) and recombinant hyaluronate lyase from Streptococcus agalactiae (rHyal B) demonstrated strongest inhibition. In contrast, hyaluronate lyases from Streptomyces hyalurolyticus (Hyal S), Streptococcus equisimilis (Hyal C) and hyaluronidase from bovine testis (Dase) showed only reduced inhibition action. A non-competitive dead end inhibition with Ki=3.1+/-1.8x10(-6) mol/mL and Kii=6.7+/-2.4x10(-6) mol/mL was found for glycyrrhizin on recombinant hyaluronate lyase from Streptococcus agalactiae. The inhibitory effect of flavonoids on Hyal B, rHyal B and Dase was determined depending on the number of hydroxyl groups and side chain substituents in the molecule. Flavonoids with many hydroxyl groups inhibited hyaluronate lyase stronger than those with only a few. Native hyaluronate lyase (Hyal B) showed a more extensive inhibition than the recombinant protein (rHyal B). Accordingly, the inhibition by triterpenes and flavonoids is presumably specific for each hyaluronic acid (HA)-splitting enzyme. 相似文献
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