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991.
992.
Hassun Filho PA Ribeiro MA da Rocha AM Allegreti JR Serafini PC da Motta EL 《Journal of assisted reproduction and genetics》2008,25(9-10):467-471
Objective
To determine whether gonadotropin releasing hormone (GnRH)-agonist or -antagonist induces higher percentages of cumulus cell apoptosis and if the use of either is detrimental to ART outcomes.Patients
Women in a private facility under treatment for IVF had their cumulus cells isolated and analyzed by flow cytometry. Viable, apoptotic, and dead cumulus cell rates related to ovarian stimulation by GnRH-agonist or -antagonist were measured and compared with fertilization and implantation rates.Results
Treatment with GnRH-agonist produced a greater number of follicles than treatment with GnRH-antagonist. No differences in implantation and pregnancy rates were found. While cumulus cell (CC) apoptosis was positively correlated with estradiol on the day of hCG administration, no significant difference in the percentage of apoptotic cells between treatments was detectable. Additionally, implantation rate and the average follicular estradiol production on the day of hCG administration were no different between treatments.Conclusions
GnRH-agonist or -antagonist treatment protocols induce similar levels of apoptosis in CCs and are not detrimental to ART outcomes. 相似文献993.
994.
995.
996.
Teresa Maria J. P. Carvalho Ricardo de Carvalho Cavalli Sérgio P. Cunha Cláudia O. de Baraldi Maria P. Marques Natalícia J. Antunes Ana Leonor P. C. Godoy Vera Lucia Lanchote 《European journal of clinical pharmacology》2011,67(1):55-61
Purpose
This study investigated the influence of gestational diabetes mellitus on the kinetic disposition and stereoselective metabolism of labetalol administered intravenously or orally. 相似文献997.
998.
Vitor Laerte Laerte Pinto Junior Maria Cristina Rebelo Rachel Novaes Gomes Edson Fernandes de Assis Hugo C. Castro-Faria-Neto Marcio Neves Bóia 《The Brazilian journal of infectious diseases》2011,15(2):156-158
Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p < 0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p < 0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685 ng/dL (100% of sensitivity and 94% of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM. 相似文献
999.
André Tomazini Gomes de Sá César Antunes de Freitas Fátima Cristina de Sá Wagner José Silva Ursi Tania Christina Sim?es Márcia Furtado Antunes de Freitas 《Journal of applied oral science : revista FOB》2008,16(1):7-11
The purpose of this study was to evaluate the accuracy of the respective dies after polyether elastomeric procedure in the presence or absence of cervical contact of the acrylic resin shell with the cervical region, establishing a comparison to dies obtained with stock trays. This study consisted of three groups with 10 specimens each: 1) acrylic copings without cervical contact, (cn); 2) acrylic copings with cervical contact (cc); 3) perforated stock tray, (st). The accuracy of the resulting dies was verified with the aid of a master crown, precisely fit to the master steel die. ANOVA test found statistically significant differences among groups (p<0.001). Tukey''s test found that the smallest discrepancy occurred in group cn, followed by cc, while the st group presented the highest difference (cc x cn: p=0.007; st x cn: p<0.001; st x cc: p<0.001). 相似文献
1000.
S Martins F Neves R M Soares D Cacela L do Rosário P Coelho J Mendes F Robalo N Castel?o A M Antunes J Roquette 《Revista portuguesa de cardiologia》1999,18(12):1111-1116
AIM: The aim of this study was to make a noninvasive comparison, by means of Doppler echocardiography, of the hemodynamic performance of biological stentless xenografts and mechanical bileaflet (MB) prostheses (P) in aortic position. METHODS: We studied 20 patients (pts) with normofunctional (nf) aortic Toronto (T) Stentless Porcine valves (SPV)--Group I--8 males, aged 69 +/- 12 years, 32 +/- 9 months after surgery, and 30 pts with nf MB aortic P (Carbomedics or St. Jude Medical)--Group II--17 males (p = NS vs G I), aged 61 +/- 12 years (p < 0.01 vs G I), 30 +/- 12 months after implantation (p = NS vs G I). Both groups were comparable with regard to body surface area and surgical indication. P diameters ranged from 21 to 25 mm (G I: 22.9 +/- 1.7; G II: 22.8 +/- 1.7 - p = NS), the number of pts with the same P diameter in each group being similar. We analysed, at rest: aortic orifice diameter (AoOd - cm), maximal (GMax) and mean (GMean) transprosthesic pressure gradients, P functional area (PFA) and P resistance (PRes). Gradients (mm Hg) were calculated by means of the Bernoulli equation, PFA (cm2) by means of the continuity equation and PRes (dynes.s.cm-5) as 1333 x Gmean x SEP/SV (SEP = systolic ejection period; SV = stroke volume). RESULTS: AoOd (G I vs G II): P 21--1.78 +/- 0.04 vs 2.00 +/- 0.10 (p < 0.001); P 23--1.91 +/- 0.10 vs 2.19 +/- 0.10 (p = 0.01); P 25--2.22 +/- 0.24 vs 2.29 +/- 0.19 (NS). Doppler parameters: [table: see text] CONCLUSIONS:P T SPV show better hemodynamic performance when compared to P MB with the same diameter, in aortic position. In addition, our results suggest that P T SPV allow the use of larger valve sizes for the same aortic orifice diameter. 相似文献