全文获取类型
收费全文 | 1056篇 |
免费 | 133篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 38篇 |
妇产科学 | 32篇 |
基础医学 | 183篇 |
口腔科学 | 30篇 |
临床医学 | 162篇 |
内科学 | 205篇 |
皮肤病学 | 12篇 |
神经病学 | 83篇 |
特种医学 | 95篇 |
外科学 | 91篇 |
综合类 | 112篇 |
预防医学 | 75篇 |
眼科学 | 16篇 |
药学 | 72篇 |
中国医学 | 1篇 |
肿瘤学 | 40篇 |
出版年
2021年 | 18篇 |
2019年 | 11篇 |
2018年 | 14篇 |
2017年 | 8篇 |
2016年 | 12篇 |
2015年 | 18篇 |
2014年 | 19篇 |
2013年 | 28篇 |
2012年 | 40篇 |
2011年 | 38篇 |
2010年 | 23篇 |
2009年 | 28篇 |
2008年 | 28篇 |
2007年 | 56篇 |
2006年 | 30篇 |
2005年 | 27篇 |
2004年 | 21篇 |
2003年 | 27篇 |
2002年 | 20篇 |
2001年 | 23篇 |
2000年 | 28篇 |
1999年 | 27篇 |
1998年 | 32篇 |
1997年 | 44篇 |
1996年 | 33篇 |
1995年 | 31篇 |
1994年 | 19篇 |
1993年 | 30篇 |
1992年 | 11篇 |
1991年 | 28篇 |
1990年 | 21篇 |
1989年 | 30篇 |
1988年 | 24篇 |
1987年 | 31篇 |
1986年 | 25篇 |
1985年 | 26篇 |
1984年 | 27篇 |
1983年 | 20篇 |
1982年 | 25篇 |
1981年 | 19篇 |
1980年 | 23篇 |
1979年 | 16篇 |
1978年 | 12篇 |
1976年 | 12篇 |
1974年 | 9篇 |
1972年 | 10篇 |
1970年 | 12篇 |
1967年 | 7篇 |
1966年 | 8篇 |
1929年 | 7篇 |
排序方式: 共有1250条查询结果,搜索用时 15 毫秒
11.
12.
K. B. Carter J. K. Drury J. R. Richards 《Medical & biological engineering & computing》1976,14(4):465-470
Calorimetry, using the gradient layer technique, has become well established in the study of energy metabolism. The use of a commercially constructed gradient layer box within a calorimetry system designed to measure directly and indirectly the metabolic sequelae of thermal injury in rats, is described. Variations in the signal output were discovered. These were found to be dependent upon:
- stability of the ambient temperature
- stability of the gradient layer box water jacket temperature
- position and size of the calibrating heat source.
13.
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry 总被引:8,自引:1,他引:8
Nistico L; Buzzetti R; Pritchard LE; Van der Auwera B; Giovannini C; Bosi E; Larrad MT; Rios MS; Chow CC; Cockram CS; Jacobs K; Mijovic C; Bain SC; Barnett AH; Vandewalle CL; Schuit F; Gorus FK; Tosi R; Pozzilli P; Todd JA 《Human molecular genetics》1996,5(7):1075-1080
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus
is determined by a combination of environmental and genetic factors, which
include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin
gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2
cannot explain the clustering of type 1 diabetes in families, and a role
for other genes is inferred. In the present report we describe linkage and
association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte
associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong
candidate gene for T cell- mediated autoimmune disease because it encodes a
T cell receptor that mediates T cell apoptosis and is a vital negative
regulator of T cell activation. In addition, we provide supporting evidence
that CTLA-4 is associated with susceptibility to Graves' disease, another
organ- specific autoimmune disease.
相似文献
14.
15.
16.
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP) 总被引:8,自引:0,他引:8
Rowe PS; Oudet CL; Francis F; Sinding C; Pannetier S; Econs MJ; Strom TM; Meitinger T; Garabedian M; David A; Macher MA; Questiaux E; Popowska E; Pronicka E; Read AP; Mokrzycki A; Glorieux FH; Drezner MK; Hanauer A; Lehrach H; Goulding JN; O'Riordan JL 《Human molecular genetics》1997,6(4):539-549
Mutations in the PEX gene at Xp22.1 (phosphate-regulating gene with
homologies to endopeptidases, on the X-chromosome), are responsible for
X-linked hypophosphataemic rickets (HYP). Homology of PEX to the M13 family
of Zn2+ metallopeptidases which include neprilysin (NEP) as prototype, has
raised important questions regarding PEX function at the molecular level.
The aim of this study was to analyse 99 HYP families for PEX gene
mutations, and to correlate predicted changes in the protein structure with
Zn2+ metallopeptidase gene function. Primers flanking 22 characterised
exons were used to amplify DNA by PCR, and SSCP was then used to screen for
mutations. Deletions, insertions, nonsense mutations, stop codons and
splice mutations occurred in 83% of families screened for in all 22 exons,
and 51% of a separate set of families screened in 17 PEX gene exons.
Missense mutations in four regions of the gene were informative regarding
function, with one mutation in the Zn2+-binding site predicted to alter
substrate enzyme interaction and catalysis. Computer analysis of the
remaining mutations predicted changes in secondary structure,
N-glycosylation, protein phosphorylation and catalytic site molecular
structure. The wide range of mutations that align with regions required for
protease activity in NEP suggests that PEX also functions as a protease,
and may act by processing factor(s) involved in bone mineral metabolism.
相似文献
17.
The leucocyte migration test (LMT) was performed on 20 patients with an intolerance to glafenin--a non-narcotic analgesic drug. LMT was found to be positive in 50% of the subjects with intolerance, a highly significant percentage as compared with the control groups. HSA-glafenin was found to be the most appropriate method for presenting the antigen, but glafenin and its hydroxylated metabolites were only found to induce a migration inhibition in the subjects intolerant to glafenin. 相似文献
18.
19.
20.