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61.
Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy. 总被引:1,自引:0,他引:1
The aim of this study was to investigate the association between clinical variables and all-cause and respiratory mortality in patients with chronic obstructive pulmonary disease (COPD) undergoing long-term oxygen therapy (LTOT). The authors retrospectively studied a historic cohort of 128 patients with COPD (126 males, mean age+/-SD 68.9+/-9.7 yrs, body mass index (BMI) 25.1+/-4.5 kg.m-2, and forced expiratory volume in one second 25.4+/-8.8% predicted), who were being treated with long-term oxygen therapy in a tertiary teaching hospital between 1992 and 1999. Comorbidity, assessed with the Charlson Index, was present in 38% of the patients. Vital status and cause of death were assessed through the population death registry. A total of 78 patients (61%) had died by the end of follow-up. Three-year survival was 55%. Death was due to respiratory causes in 77% of cases. On Cox analysis, BMI<25 kg.m-2, comorbid conditions, age>or=70 yrs and cor pulmonale were associated with all-cause mortality. The BMI and comorbidity were the only significant predictive factors when the analysis was restricted to respiratory mortality. In conclusion, body mass index<25 kg.m-2 and comorbidity were predictors of all-cause and respiratory mortality in a cohort of chronic obstructive pulmonary disease patients treated with long-term oxygen therapy. These factors should be taken into account when considering the management and prognosis of these patients. 相似文献
62.
醋酸精氨酸对创烧伤患者预后的影响及安全性分析——86例多中心、随机、双盲、安慰剂对照试验 总被引:1,自引:0,他引:1
目的观察服用醋酸精氨酸对创烧伤患者预后的影响及可能出现的不良反应。方法采用多中心、随机、双盲、安慰剂平行对照的研究方法,将96例创烧伤患者(实际完成86例)随机分为治疗组和对照组,治疗组41例,服用醋酸精氨酸0.4 g·kg-1·d-1;对照组45例,服用安慰剂酪氨酸,剂量同前,均连用7 d。两组患者采用等氮、等热量的营养支持疗法。比较患者创面(切口)愈合时间、住院时间及不良反应发生情况。结果创伤患者治疗组(29例)创面(切口)愈合时间和住院时间分别为(11.1±2.8)、(19±6)d,明显短于对照组(13.2±5.5)、(22±6)d(33例,P< 0.05);烧伤患者治疗组(12例)创面愈合时间和住院时间各为(20±5)、(28±6)d,与对照组(22±8)、(29±8)d(12例)比较,差异无统计学意义(P>0.05)。在整个试验过程中,患者出现的不良反应为恶心、腹泻,其中治疗组1例占2.44%,对照组1例占2.22%,两组比较差异无统计学意义(P= 1.000)。以上不良反应停药后消失。结论服用醋酸精氨酸能显著促进创伤患者创面(切口)愈合,缩短住院时间,且无明显不良反应,但对烧伤患者的预后无明显改善,这可能与病例数较少有关,其确切疗效有待于通过大样本的临床试验予以确定。 相似文献
63.
急慢性肠系膜缺血性疾病的手术治疗 总被引:2,自引:0,他引:2
董国祥 《中国实用外科杂志》2006,26(6):463-464
尽管近年来外科诊治水平发展很快,但对肠系膜缺血的治疗因认识不足而被延误的状况仍未得到根本改变,病死率仍高达60%以上,有的医院甚至高达100%。其原因,一是本病少见,只占住院病人的7%-13%;对于一名外科医生来说,其一生处理过的肠系膜缺血病人也不足十余例,没有更多的经验。另一个原因也是因为本病发病率低,在遇到急腹症时较少想到本病。等到诊断清楚以后,为时已晚。如能在遇到急腹症时想到了肠系膜缺血,并采用各种手段排除或确定它,就会减少对本病的延误,从而根本改变目前诊治本病的现状。 相似文献
64.
65.
66.
A. HAZIOT I. KATZ G. W. RONG X. Y. LIN J. SILVER & S. M. GOYERT 《Scandinavian journal of immunology》1997,46(3):242-245
Membrane-bound CD14 acts as a receptor for lipopolysaccharide (LPS) on monocytes/macrophages and neutrophils. Studies have suggested that the activation of monocytes/macrophages by the binding of LPS to membrane-bound CD14 may require the association of a signal-transducing molecule with membrane-bound CD14. The observation that non-CD14 expressing cells, such as endothelial cells, can nevertheless be activated by a complex of LPS and a soluble form of CD14 (sCD14) suggests that the receptor for this complex may be identical to the signal transducing molecule associated with membrane-bound CD14. The studies described show that two CD14-specific MoAb are able to block the LPS-induced activation of endothelial cells but do not affect the response of monocytes to LPS. This suggests that the interaction of the sCD14:LPS complex with endothelial cells is distinct from the interaction of membrane-bound CD14 with its putative signal-transducing molecule. 相似文献
67.
Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. 总被引:6,自引:0,他引:6
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X Y Song M Gu W W Jin D M Klinman S M Wahl 《The Journal of clinical investigation》1998,101(12):2615-2621
Transforming growth factor beta is a potent immunomodulator with both pro- and antiinflammatory activities. Based on its immunosuppressive actions, exogenous TGF-beta has been shown to inhibit autoimmune and chronic inflammatory diseases. To further explore the potential therapeutic role of TGF-beta, we administered a plasmid DNA encoding human TGF-beta1 intramuscularly to rats with streptococcal cell wall-induced arthritis. A single dose of 300 microg plasmid DNA encoding TGF-beta1, but not vector DNA, administered at the peak of the acute phase profoundly suppressed the subsequent evolution of chronic erosive disease typified by disabling joint swelling and deformity (articular index = 8.17+/-0. 17 vs. 1.25+/-0.76, n = 6, day 26, P < 0.01). Moreover, delivery of the TGF-beta1 DNA even as the chronic phase commenced virtually eliminated subsequent inflammation and arthritis. Both radiologic and histopathologic as well as molecular evidence supported the marked inhibitory effect of TGF-beta1 DNA on synovial pathology, with decreases in the inflammatory cell infiltration, pannus formation, cartilage and bone destruction, and the expression of proinflammatory cytokines that characterize this model. Increases in TGF-beta1 protein were detected in the circulation of TGF-beta1 DNA-treated animals, consistent with the observed therapeutic effects being TGF-beta1 dependent. These observations provide the first evidence that gene transfer of plasmid DNA encoding TGF-beta1 provides a mechanism to deliver this potent cytokine that effectively suppresses ongoing inflammatory pathology in arthritis. 相似文献
68.
糖耐量试验对评价肝癌患者肝脏储备功能的价值 总被引:5,自引:0,他引:5
绝大多数肝细胞性肝癌患者合并肝硬变,为预测其对肝切除的耐受性,给正确选择切肝患者提供依据,作者对62例切肝者和49例未切肝者手术前后的糖耐量试验(OGTT)和肝组织病理学进行了对比研究。结果:术前OGTT曲地P型者切肝后恢复顺利;L型者对肝切的耐受性差,术后易发生肝功能衰竭等并发症,其肝硬化和蔼多为CⅢ或CⅣ级,曲线形态界于P和L型之间的I型患者29例用肝门区域血管阻断法切肝,并在阻断血管前使用预 相似文献
69.
V. S. Akhunov T. V. Mirenburg X. D. Krasnopolskaya 《Journal of inherited metabolic disease》1994,17(1):104-111
Summary GM1- and GM2-gangliosides were isolated from brain and radio-labelled. The labelled moieties were localized by hydrolysis with lysosomal enzymes, followed by thin-layer chromatography of the products. High-resolution loading tests with labelled gangliosides were developed and found to differentiate infantile and juvenile forms of GM1- and GM2-gangliosidoses as well as the identification of B, O and AB types of GM2-gangliosidosis. 相似文献
70.
Prior immunologic experience potentiates the subsequent antibody response when Salmonella strains are used as vaccine carriers. 总被引:6,自引:5,他引:1
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Prior immunologic experience with homologous and heterologous serotype Salmonella strains potentiated the subsequent antibody response when the same strains were used as vaccine carriers of foreign antigens. This potentiation was positively correlated with the appearance of antibody directed against the lipopolysaccharide of the carrier strain. Both serum and mucosal antibody responses against the foreign antigen increased over time. Antibody responses in sera of animals primed with either the homologous or heterologous serotype strain were not statistically significantly different, while animals primed with the homologous serotype strain developed significantly better mucosal antibody responses against the foreign antigen. 相似文献