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排序方式: 共有1917条查询结果,搜索用时 15 毫秒
91.
Alfredo D. Guerron Shamil Aliyev Orhan Agcaoglu Erol Aksoy Halit Eren Taskin Federico Aucejo Charles Miller John Fung Eren Berber 《Surgical endoscopy》2013,27(4):1138-1143
Background
Findings have shown laparoscopic liver resection (LLR) to be feasible and safe, but the data in the literature regarding oncologic outcomes are scant. This study aimed to compare the perioperative and short-term oncologic outcomes between LLR and open resection of colorectal liver metastasis (CLM).Methods
Between January 2006 and April 2012, 40 patients underwent LLR of CLM. These patients were compared with a consecutive matched group of 40 patients who underwent open resection within the same period. Data were obtained from a prospective institutional review board (IRB)-approved database. Statistical analysis was performed using t test, Chi-square, and Kaplan–Meier survival.Results
The groups were similar in terms of age, gender, tumor size, number of tumors, and type of resections performed. The operative time was similar in the two groups, but the estimated blood loss was less in the LLR group than in the open resection group. The length of stay was shorter in the LLR group (3.7 vs 6.5 days; p < 0.001). The 2-year overall survival rate was 89 % for LLR and 81 % for open resection. The median disease-free survival time was 23 months in each group.Conclusions
The findings suggest that LLR is associated with less blood loss and a shorter hospital stay than open resection for CLM. According to our short-term results, LLR is equivalent to open resection in terms of oncologic outcomes. 相似文献92.
Ozdogan M Ersoy E Dundar K Albayrak L Devay S Gundogdu H 《The Journal of surgical research》2005,129(2):260-264
BACKGROUND: Underlying hepatic injury and cirrhosis are leading factors that interfere with the post-operative liver regeneration and function. Hyperbaric oxygenation (HBO) has been reported to ameliorate the ischemia-reperfusion injury of the liver, to induce compensatory hypertrophy of the predicted remnant liver in rats after portal vein ligation and to augment liver regeneration after hepatectomy in non-cirrhotic rats. Our aim was to determine the effect of HBO treatment on liver regeneration after partial hepatectomy in normal and cirrhotic mice in this experimental study. MATERIALS AND METHODS: The effect of HBO on liver regeneration was studied in a mice model combining carbon tetrachloride induced cirrhosis and partial hepatectomy. Mice were divided into four groups: Control, cirrhotic, non-cirrhotic HBO-treated, and cirrhotic HBO-treated. All animals underwent 40% hepatectomy. Liver regeneration was evaluated by the proliferating cell nuclear antigen-labeling index. Serum aspartate aminotransferase and alanine aminotransferase levels were measured to evaluate liver injury. RESULTS: Serum alanine aminotransferase and aspartate aminotransferase levels were significantly decreased in HBO-treated cirrhotic group compared to cirrhosis group after hepatectomy (P = 0.001 and P = 0.014, respectively). The proliferating cell nuclear antigen labeling index was significantly higher in HBO treated cirrhotic group than in cirrhotic group after hepatectomy (P = 0.022). CONCLUSIONS: Our results suggest that HBO treatment improves liver functions and augments hepatocyte regeneration in cirrhotic mice after hepatectomy. Post-operative HBO treatment may have a beneficial effect on post-operative liver function and regeneration in cirrhotic patients. 相似文献
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95.
BD Heckman KA Holroyd G Tietjen FJ O'Donnell L Himawan C Utley R Watakakosol & M Stillman 《Cephalalgia : an international journal of headache》2009,29(6):650-661
This study sought to determine if Whites and African-Americans respond similarly to headache treatment administered in 'real-world' headache specialty treatment clinics. Using a naturalistic, longitudinal design, 284 patients receiving treatment for headache disorders completed 30-day daily diaries that assessed headache frequency and severity at pretreatment and 6-month follow-up and also provided data on their headache disability and quality of life at pretreatment and 1-, 2- and 6-month follow-up. Controlling for socioeconomic status and psychiatric comorbidity, hierarchical linear models found that African-Americans and Whites reported significant reductions in headache frequency and disability and improvements in life quality over the 6-month treatment period. African-Americans, unlike Whites, also reported significant decreases in headache severity. Nevertheless, Africans-Americans had significantly more frequent and disabling headaches and lower quality of life after treatment relative to Whites. Although Whites and African Americans responded favourably to headache treatments, more efficacious treatments are needed given the elevated level of headache frequency that remained in both racial groups following treatment. 相似文献
96.
L. Zheng PhD Y.-p. Qing MD N. Xu MD Q. Yu BD Y. Wang BD F.-p. Wang† PhD Z.-y. Li‡ MD 《Journal of clinical pharmacy and therapeutics》2010,35(1):113-119
Objective: To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P‐glycoprotein (P‐gp), after single‐dose i.v. infusion in healthy Chinese volunteers. Methods: We conducted a randomized, dose‐escalating, phase I clinical study for that purpose. Thirty healthy subjects received BrTet at the doses of 10, 20 or 30 mg/m2 by i.v. infusion. Plasma and urine concentrations of bromotetrandrine were determined by using a liquid chromatography–tandem mass spectrometric (LC/MS/MS) method. AUC was calculated by the trapezoidal rule extrapolation method. Cmax, Tmax, t1/2α, t1/2β, Cl and Vd were compiled from the plasma concentration–time data. Results: Bromotetrandrine was generally well tolerated at all doses. No serious or severe adverse events were found in the study. The pharmacokinetic parameters of BrTet after single i.v. infusion doses of BrTet 10, 20 and 30 mg/m2 were as follows: Tmax were 1·5 h in three groups, Cmax were 24·79, 39·59 and 64·31 μg/L, t1/2α were 0·37, 0·29 and 0·30 h, t1/2β were 62·88, 56·45 and 52·20 h. AUC0–194h were 345·83, 688·15 and 1096·28 μg h/L, Cl were 23·68, 25·69 and 25·66 L h/m2, Vd were 157·73,156·96 and 140·73 L/m2. In urine, the total eliminate rate of originate compound was 0·61 ± 0·19%. Conclusions: This study suggested that bromotetrandrine was well tolerated in healthy volunteers within the dose range evaluated. The pharmacokinetics parameters of bromotetrandrine indicated that the compound was rapidly distributed and accumulated in the tissues, and slowly cleared from plasma, which supported the use of BrTet for a once or twice dosing per chemotherapy cycle. 相似文献
97.
Gloria Peiró MD Encarna Adrover MD Jaime Guijarro MD Irene Ballester MD M. José Jimenez MD María Planelles MD Lluis Catasús BD 《The breast journal》2010,16(1):77-81
Abstract: Synchronous bilateral breast carcinoma (SBBC) and early onset are important characteristics of hereditary cases. The lifetime risk for breast carcinoma in Cowden syndrome (CS) is estimated to be 25–50%. We reported a 44‐year‐old woman presenting SBBC and characteristic mucocutaneous lesions of CS, confirmed by PTEN gene mutation analysis. Bilateral modified mastectomy and axillary dissection were performed. Histopathologic examination revealed a moderate‐differentiated invasive ductal carcinoma with mixed features of luminal A immunophenotype (Estrogen and/or Progesterone Receptors >50% and/or Ki67 < 30% of positive cells). The skin lesions showed the characteristic findings of tricholemmoma. Lack of PTEN expression was observed in all specimens. Sequencing analysis confirmed the presence of PTEN splice‐acceptor site mutation in intron 8 (c.1027‐2A>G), a germline mutation which had not been previously reported in CS. The patient received adjuvant chemotherapy and tamoxifen for 5 years. After 5 years of follow‐up, she persists recurrence‐free. SBBC with early onset suggests a hereditary predisposition. Thus, analysis of PTEN expression abnormality, easily assessed by immunohistochemistry, may be of clinical value to screen those patients with CS. 相似文献
98.
99.
Free tissue transfers have been rapidly replacing distant flaps for use in nasal reconstruction. The temporoparietal fascial flap is a thin, broad, pliable, and well-vascularized flap. It can be used to drape over the cartilaginous and bony framework of the nasal skeleton and nourish the underlying primary cartilage grafts as well as the overlying full-thickness skin graft. The thin contour of the flap is aesthetically superior to thicker skin flaps and eliminates the need for secondary defatting or touch-up procedures. A large, single sheet of full-thickness skin graft, harvested from the supraclavicular region, can be applied over the fascial flap in the same session and provide a quite acceptable color match. The authors present a case whose alar margins and atrophic nasal skin were restored in one session by primary conchal cartilage grafts, a free temporoparietal fascial flap, and a full-thickness supraclavicular skin graft. 相似文献
100.
We previously reported on the safety and
efficacy of laparoscopic radiofrequency thermal ablation (RFA) for
treating hepatic neuroendocrine metastases. The aim of
this study is to report our 5-year RFA experience in the treatment of
these challenging group of patients. Of the 222 patients with 803 liver
primary and secondary tumors undergoing laparoscopic RFA between
January 1996 and August 2001, a total of 34 patients with 234 tumors
had neuroendocrine liver metastases. There were 25 men and 9 women with
a mean ± SEM age of 52 ± 2 years who underwent 42
ablations. Primary tumor types included carcinoid tumor in 18 patients,
medullary thyroid cancer in 7, secreting islet cell tumor in 5, and
nonsecreting islet cell tumor in 4. There was no mortality, and the
morbidity was 5%. The mean hospital stay was 1.1 days. Symptoms were
ameliorated in 95%, with significant or complete symptom control in
80% of the patients for a mean of 10+ months (range 6–24 months). All
patients were followed for a mean ± SEM of 1.6 ± 0.2 years
(range 1.0–5.4 years). During this period new liver lesions developed
in 28% of patients, new extrahepatic disease in 25%, and local liver
recurrence in 13%; existing liver lesions progressed in 13%.
Overall 41% of patients showed no progression of their cancer. Nine
patients (27%) died. Mean ± SEM survivals after diagnosis of
primary disease, detection of liver metastases, and performance of RFA
were 5.5 ± 0.8 years, 3.0 ± 0.3 years, and 1.6 ± 0.2
years, respectively. Sixty-five percent of the patients demonstrated a
partial or significant decrease in their tumor markers during
follow-up. In conclusion, RFA provides excellent local tumor control
with overnight hospitalization and low morbidity in the treatment of
liver metastases from neuroendocrine tumors. It is a useful modality in
the management of these challenging group of patients. 相似文献