全文获取类型
收费全文 | 3368649篇 |
免费 | 249307篇 |
国内免费 | 8846篇 |
专业分类
耳鼻咽喉 | 45570篇 |
儿科学 | 110071篇 |
妇产科学 | 91803篇 |
基础医学 | 473826篇 |
口腔科学 | 94270篇 |
临床医学 | 308889篇 |
内科学 | 661662篇 |
皮肤病学 | 77196篇 |
神经病学 | 277655篇 |
特种医学 | 130950篇 |
外国民族医学 | 952篇 |
外科学 | 503364篇 |
综合类 | 72814篇 |
现状与发展 | 5篇 |
一般理论 | 1290篇 |
预防医学 | 265843篇 |
眼科学 | 74806篇 |
药学 | 246748篇 |
11篇 | |
中国医学 | 6625篇 |
肿瘤学 | 182452篇 |
出版年
2019年 | 26104篇 |
2018年 | 36851篇 |
2017年 | 28272篇 |
2016年 | 32545篇 |
2015年 | 36705篇 |
2014年 | 50851篇 |
2013年 | 76826篇 |
2012年 | 101620篇 |
2011年 | 107798篇 |
2010年 | 64953篇 |
2009年 | 62197篇 |
2008年 | 100543篇 |
2007年 | 107031篇 |
2006年 | 108844篇 |
2005年 | 104650篇 |
2004年 | 100873篇 |
2003年 | 97274篇 |
2002年 | 93707篇 |
2001年 | 161994篇 |
2000年 | 166420篇 |
1999年 | 140001篇 |
1998年 | 40405篇 |
1997年 | 35941篇 |
1996年 | 36398篇 |
1995年 | 35381篇 |
1994年 | 32640篇 |
1993年 | 30534篇 |
1992年 | 110355篇 |
1991年 | 106557篇 |
1990年 | 103217篇 |
1989年 | 99365篇 |
1988年 | 91291篇 |
1987年 | 89704篇 |
1986年 | 84394篇 |
1985年 | 80645篇 |
1984年 | 60413篇 |
1983年 | 51127篇 |
1982年 | 30393篇 |
1981年 | 27225篇 |
1979年 | 53901篇 |
1978年 | 38301篇 |
1977年 | 32329篇 |
1976年 | 30021篇 |
1975年 | 32044篇 |
1974年 | 38018篇 |
1973年 | 36264篇 |
1972年 | 33872篇 |
1971年 | 31441篇 |
1970年 | 28913篇 |
1969年 | 27511篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
PCP and related compounds inhibit 3H-mazindol binding to the cocaine receptor on dopamine transporters. The relative potencies of these compounds are such that some of the behavioral effects of PCP could be related to its action at the cocaine receptor; however, the affinity of PCP at the cocaine site (Ki = 1.59 microM) is less than its affinity at its own receptor (Ki about 0.12 microM). More data will be needed to conclusively implicate the cocaine receptor in the action of PCP. 相似文献
992.
A Espinosa de los Monteros G Roussel N M Neskovic J L Nussbaum 《Journal of neuroscience research》1988,19(2):202-211
A new chemically defined medium consisting of equal parts of Dulbecco modified Eagle's and Ham's F-12 media supplemented with insulin, sodium selenite, putrescine, and D+ galactose, which allows the long-term survival of mature oligodendrocyte pure cultures, is described. Immunohistochemical staining has shown that over 90% of the cells become positive for myelin proteins shortly following subculture. Contaminating astrocytes (2%) do not survive in this medium. Biochemical data have indicated that these purified oligodendrocytes express 2'3'-cyclic nucleotide 3'-phosphohydrolase and UDP-galactose ceramide galactosyltransferase activities. Electron microscopical examination revealed that the oligodendrocytes were mostly of medium-dark type and appeared to be identical to cells cultured in serum-containing medium. The ability to maintain pure oligodendrocyte cultures in such a defined medium will allow investigations concerning exogenous and endogenous factors involved in oligodendrocyte metabolism. 相似文献
993.
994.
995.
Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia 总被引:1,自引:0,他引:1
R C Hider L Ejim P D Taylor R Gale E Huehns J B Porter 《Biochemical pharmacology》1990,39(6):1005-1012
The ability of a number of heterocyclic metal chelators to deliver zinc into red cells, to release the liganded zinc to haemoglobin and thereby cause a left shift in the oxygen dissociation curve of intact red cells has been investigated. Incubation of neutrally charged zinc-pyrone and zinc-pyridin-2-one complexes with red cells led to the rapid accumulation of zinc within cells, whereas unliganded zinc in the form of zinc acetate, zinc chloride or zinc sulphate accumulated only slowly. The rate at which zinc was delivered to red cells by pyrone and pyridin-2-one ligands increased with increasing lipid solubility of the ligands. The uptake of zinc into both normal adult and sickle red cells was associated with a dose-dependent increase in the oxygen affinity of haemoglobin. The degree of left shift in the oxygen dissociation curve following the incubation of red cells with zinc-pyrone and -pyridin-2-one complexes suggests that these complexes may find application as agents to increase the oxygen affinity of haemoglobin in sickle cell disease and thereby decrease the probability of intravascular sickling at low tissue oxygen tensions. Ethylmaltol appears to be a particularly useful agent due to its known low toxicity. 相似文献
996.
Two unique forms of cytochrome P-450 (P-450), designated NMa and NMb, were recently isolated in this laboratory from nasal microsomes of rabbits. In the present study, polyclonal antibodies to the purified nasal cytochromes were prepared. Immunochemical analysis with specific rabbit anti-NMa and sheep anti-NMb antibodies indicated that P-450 isozymes identical to or having a high structural homology with NMa are present in both olfactory and respiratory mucosa, as well as in liver, but NMb was detected only in the olfactory mucosa. Neither form was detected in other tissues examined, including brain, esophageal mucosa, heart, intestinal mucosa, kidney, and lung. The specific occurrence of NMb in the olfactory mucosa was further substantiated by the detection and specific inhibition by anti-NMb of the formation of unique NMb-dependent metabolites of testosterone in olfactory microsomes but not in microsomes from liver or respiratory mucosa. Similar experiments with antibodies to previously purified rabbit hepatic P-450 isozymes indicated that not all of the hepatic cytochromes are expressed in the nasal tissues. Thus, P-450 isozymes structurally homologous to hepatic forms 2, 3a, and 4, but not 3b and 6, were found in the olfactory mucosa. On the other hand, only form 2 was detected in the respiratory mucosa. Immunoquantitation experiments revealed that NMa and NMb are the major P-450 forms in olfactory microsomes, whereas NMa and P-450 form 2 (or its homolog) constitute the major portion of the respiratory nasal microsomal P-450. The level of NMa in the liver is relatively low, accounting for less than 3% of total microsomal P-450 in this tissue. In addition, evidence is provided that NMa is the major catalyst in the dealkylation of two nasal carcinogens, hexamethylphosphoramide and phenacetin, in both olfactory and respiratory nasal microsomes. 相似文献
997.
998.
999.
H Murakami M Togawa S Takahashi N Kasahara J Yamamoto N Matsuura Y Koshiyama Y Ino M Oda 《Arzneimittel-Forschung》1990,40(12):1352-1358
The effects of FUT-187 (6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate, CAS 103926-82-5), a novel synthetic protease inhibitor, were examined in experimental rat and canine models of pancreatitis. 1. FUT-187 significantly increased the survival of rats with trypsin- and phospholipase A2-induced pancreatitis in a dose-dependent manner (10-100 mg/kg, p.o.). 2. FUT-187 decreased plasma enzymatic activity reflecting the degree of pancreatitis in rats with ethionine-induced pancreatitis, and showed a tendency to ameliorate histopathological changes in the pancreas (10-100 mg/kg p.o.). 3. FUT-187 (10 mg/kg) produced an obvious improvement of various biochemical parameters of pancreatitis and also reduced histopathological changes in the pancreas in animals with experimental pancreatitis produced by the closed duodenal loop method. In addition, FUT-187 significantly increased the survival of dogs when given by direct administration into the lumen of the closed duodenal loop. The therapeutic effects of FUT-187 in experimental pancreatitis were nearly equal in most instances to those of camostat mesilate. Thus, FUT-187 would appear to be an effective new agent for the treatment of pancreatitis. 相似文献
1000.
G Durrieu P Valet M Berlan A Villeneuve J L Montastruc 《European journal of pharmacology》1990,182(3):597-601
Treatment of dogs for 21 days with oral levodopa (100 mg b.i.d.) plus benserazide (25 mg b.i.d.) induced a significant increase in the number of platelet alpha 2-adrenoceptors labelled by [3H] yohimbine with no change in Kd. The rise was maximal at the end of the treatment and remained significant during the month following the cessation of treatment. Plasma catecholamine levels did not vary. Competition experiments showed a low affinity of both dopamine and levodopa for platelet alpha 2-adrenoceptors. These results suggest that levodopa treatment regulates alpha 2-adrenoceptor number in dog platelets. 相似文献