全文获取类型
收费全文 | 2322235篇 |
免费 | 173823篇 |
国内免费 | 7655篇 |
专业分类
耳鼻咽喉 | 30971篇 |
儿科学 | 73783篇 |
妇产科学 | 61837篇 |
基础医学 | 321740篇 |
口腔科学 | 64207篇 |
临床医学 | 209660篇 |
内科学 | 460664篇 |
皮肤病学 | 53409篇 |
神经病学 | 186213篇 |
特种医学 | 94304篇 |
外国民族医学 | 472篇 |
外科学 | 358896篇 |
综合类 | 50836篇 |
现状与发展 | 3篇 |
一般理论 | 821篇 |
预防医学 | 178375篇 |
眼科学 | 51123篇 |
药学 | 172345篇 |
11篇 | |
中国医学 | 4691篇 |
肿瘤学 | 129352篇 |
出版年
2018年 | 24614篇 |
2017年 | 19321篇 |
2016年 | 22563篇 |
2015年 | 25292篇 |
2014年 | 35099篇 |
2013年 | 52364篇 |
2012年 | 67592篇 |
2011年 | 72214篇 |
2010年 | 43797篇 |
2009年 | 41987篇 |
2008年 | 67293篇 |
2007年 | 71840篇 |
2006年 | 73053篇 |
2005年 | 70407篇 |
2004年 | 67508篇 |
2003年 | 65334篇 |
2002年 | 62680篇 |
2001年 | 113200篇 |
2000年 | 116396篇 |
1999年 | 97574篇 |
1998年 | 28060篇 |
1997年 | 24847篇 |
1996年 | 25569篇 |
1995年 | 25083篇 |
1994年 | 23166篇 |
1993年 | 21883篇 |
1992年 | 77679篇 |
1991年 | 75366篇 |
1990年 | 73115篇 |
1989年 | 70167篇 |
1988年 | 64423篇 |
1987年 | 63089篇 |
1986年 | 59539篇 |
1985年 | 56979篇 |
1984年 | 42693篇 |
1983年 | 36042篇 |
1982年 | 21903篇 |
1981年 | 19514篇 |
1980年 | 18379篇 |
1979年 | 38268篇 |
1978年 | 27105篇 |
1977年 | 23474篇 |
1976年 | 21039篇 |
1975年 | 22674篇 |
1974年 | 26440篇 |
1973年 | 25424篇 |
1972年 | 23724篇 |
1971年 | 22062篇 |
1970年 | 20200篇 |
1969年 | 19146篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
Although psychoanalysis was the first-choice treatment for premature ejaculation (PE) between 1920 and 1960, hardly any reports on its efficacy have been published. Moreover, a scientific debate about its findings has never been fully developed. The recent progress that has been made in the classification of three different PE syndromes creates a new opportunity for psychoanalytic investigations of men with complaints of PE, distinguished by the actual duration of their intravaginal ejaculation latency time (IELT). The term premature-like ejaculatory dysfunction has been introduced to distinguish men with self-perceived PE at normal and long IELT durations from those men with lifelong, acquired and normal variable PE. Psychoanalytic research may contribute to a better understanding of the consequences of objective early ejaculations on the unconscious mental life of men with the four forms of PE. By integrating neurobiological, clinical and epidemiological data of ejaculatory performance, a revival of psychoanalytic research of PE in the four distinct, classified PE groups, will probably contribute to a deeper insight in to the unconscious mental life of men affected by PE. 相似文献
52.
Deng H. Le W. - D. Hunter C. B. 《世界核心医学期刊文摘》2006,2(6):17-18
背景:Parkin基因(PRKN)突变可导致常染色体隐性遗传性早发帕金森病(EOPD)。目的:探讨EOPD白人家族PRKN突变的表现和基因型-表型关系。设计:对EOPD家族的3代20例成员进行基因分析,该家族有4例患者。应用直接基因组DNA测序、半定量聚合酶链反应、实时定量聚合酶链反应以及逆转录酶聚合酶链反应分析以确定PRKN突变。结果:4例早发患者(年龄30—38岁)被确定有PRKN复合杂合突变(T240M和EX5_6缺失),虽然PRKN的杂合T240M和纯合EX5_6缺失突变已有描述,但是据悉,本文为上述复合杂合突变的首次报道。患者的表型为典型常染色体隐性遗传性EOPD的表现,其特征是对左旋多巴治疗有效、相对缓慢的进展和运动障碍。所有杂合突变的基因携带者(T240M或EX5_6缺失)和1例56岁的复合杂合突变女性携带者(T240M和EX5_6缺失)无任何神经系统症状。结论:研究发现,PRKN基因复合杂合突变(T240M和EX5_6缺失)导致一个大的白人家族中4例成员发生常染色体隐性遗传性EOPD。另外1例成员具有相同的突变,比4例患者的平均发病年龄大10岁,并且无本病的临床表现。不完全的外显率对遗传咨询具有暗示作用,并且提示复杂的基因一环境交互作用在PRKN相关EOPD的发病机制中发挥作用。 相似文献
53.
Pulmonary hamartomas are usually an incidental finding and range in size from 1 cm to 8 cm in diameter in various series. We report a case of a massive pulmonary hamartoma (size 25.5 × 17.5 × 6.5 cm and weighing 1134 g) in a 61 year old male who presented with a short history of breathlessness. The tumour was arising from the medial border of the right lung and occupying most of the right chest extending in to the anterior mediastinum. The tumour was compressing the right lung and there was no evidence of infiltration into the surrounding structures. It was successfully treated by surgical resection and final histology was pulmonary hamartoma with predominantly adipose and leiomyomatous differentiation. 相似文献
54.
Sebastian Bonner Thomas Matte Mitchell Rubin Joanne K Fagan Jennifer Ahern David Evans 《The Journal of asthma》2006,43(1):31-35
Although studies have documented underuse of controller medications and overuse of short-acting inhaled ss(2)-agonist among children with persistent asthma in disadvantaged communities, the persistence of oral ss(2)-agonist use in pediatric practice has not been studied since inhaled short-acting ss(2)-agonists became widespread. We describe medications used to treat asthma among children 3 to 5 years of age at 10 Head Start and other subsidized preschool centers in East and Central Harlem, New York City. We interviewed 149 parents/guardians of children who were identified as having probable asthma based on physician's diagnosis, persistent symptoms, hospitalization, and medication use. We classified 86 of the 149 children (58%) as having current persistent asthma. Only 15 of them (17%) were reported to have used controller medications at least 5 days/week in the last 4 weeks-only 2 of whom used inhaled corticosteroids. By contrast, 53 children (62%) used oral ss(2)-agonist in the last 4 weeks, often (72%) in conjunction with nebulized or inhaled short-acting ss(2)-agonist. Use of oral ss(2)-agonist was associated with more severe symptoms. This study documents the continued widespread use of oral ss(2)-agonist for treatment of children in a low-income community with high prevalence of asthma. 相似文献
55.
56.
57.
R Srikanth D Mukunda Reddy A Mosahebi 《Journal of plastic, reconstructive & aesthetic surgery》2006,59(12):1318-1324
The numbers of free flap donor site as well as their indications are constantly increasing. Despite increasing popularity of microvascular reconstructive procedures, literature lacks clear and objective outcome criteria. This paper reports on a simple outcome classification that has become a routine part of the unit's large workload of microvascular outcome recording. The classification was formed through a retrospective analysis of 241 consecutive cases from 2000 to 2001 and is a five graded numerical classification. Grade 1 equates to total success without co-morbidity and grade 5 to a major complication such as amputation, etc., whatever the status of the flap itself. From 2002 to 2005 the classification was prospectively used on 527 consecutive cases with ease of integration into routine clinical practice. The Classification would enable a more objective record keeping thus analysis of the outcome. It would allow a more realistic comparison of different techniques or donor types as well set a benchmarking level for further improvement of the results. 相似文献
58.
59.
To determine if impaired energy metabolism might contribute to some aspects of Alzheimer disease (AD), including the vulnerability of the CA1 region of the hippocampal formation and the altered cytoskeleton evident in neurofibrillary tangles, we examined the effects of metabolic poisons on neuronal damage and cytoskeletal disruption in the hippocampal formation. Intrahippocampal injection of 3-nitropropionic acid (3-NP) and malonic acid resulted in neuronal death, particularly in CA1. Cytoskeletal disruption included loss of dendritic MAP2, but sparing of axonal τ. MK-801 (a noncompetitive NMDA receptor antagonist) did not atenuate the lesions produced by intrahippocampal injection of malonate. MK-801, however, was effective against intrastriatal malonate. Acute systemic 3-NP resulted in neuronal damage and cytoskeletal disruption in the CA1 region of the hippocampal formation, including an extensive loss of MAP2 immuno-reactivity, but sparing of τ. The neuronal loss in CA1 was delayed as compared to striatum. Chronic intraventricular infusion of 3-NP produced a different pattern of neuronal damage. Loss of τ-1 immuno-reactivity was observed in CA3 and CA1 s. oriens, whereas MAP2 immunostaining was preserved. These results demonstrate that chronic and acute administration of metabolic inhibitors produce distinct patterns of neuronal damage and cytoskeletal disruption. The results further suggest a differential involvement of the NMDA receptor in malonate-induced neuronal damage in striatum as compared to the hippocampus. The pattern of neuronal damage and cytoskeletal disruption observed following acute metabolic impairment resembled some aspects of neurofibrillary pathology in AD, but did not result in τ hyperphosphorylation. 相似文献
60.
Effects of poor glucose handling on arterial stiffness and left ventricular mass in normal children.
AIM: Cardiovascular risk factors can be present in children and young adults. We previously found abnormal microvascular function in children who had glucose intolerance and insulin resistance. The aim of the present study was to investigate whether they also have abnormalities in left ventricular mass (LVM) and arterial stiffness. METHODS: We measured heart dimensions and LVM using echocardiography, and arterial stiffness using pulse wave analysis in 23 children with good glucose handling (postfeeding glucose: 3.9 to 5 mmol/L) and 21 with poor glucose handling (7.7 to 11.4 mmol/L). RESULTS: The time to pulse reflection was slightly shorter in the poorer glucose handlers (mean+/-SD: 143+/-10 vs 153+/-20 ms, P=0.04), suggestive of increased arterial stiffness. Also in this group, there were significant relationships between intraventricular septal thickness, blood pressure and body mass index, but not in the normal glucose handlers. CONCLUSIONS: We have found that normal children who are in the lowest quintile of glucose tolerance in comparison with their peers are exhibiting the first signs of arterial stiffening. In addition, we have seen the beginnings of a relationship between blood pressure, body mass index and left ventricular enlargement in this group. While these changes may not yet be clinically significant, their emergence might be further evidence of early predisposition to cardiovascular disease. 相似文献