全文获取类型
收费全文 | 33609篇 |
免费 | 2014篇 |
国内免费 | 425篇 |
专业分类
耳鼻咽喉 | 550篇 |
儿科学 | 354篇 |
妇产科学 | 462篇 |
基础医学 | 5590篇 |
口腔科学 | 880篇 |
临床医学 | 2740篇 |
内科学 | 6412篇 |
皮肤病学 | 1329篇 |
神经病学 | 2453篇 |
特种医学 | 2270篇 |
外国民族医学 | 1篇 |
外科学 | 4146篇 |
综合类 | 181篇 |
一般理论 | 5篇 |
预防医学 | 1584篇 |
眼科学 | 586篇 |
药学 | 3384篇 |
中国医学 | 444篇 |
肿瘤学 | 2677篇 |
出版年
2024年 | 23篇 |
2023年 | 244篇 |
2022年 | 771篇 |
2021年 | 1238篇 |
2020年 | 560篇 |
2019年 | 798篇 |
2018年 | 976篇 |
2017年 | 800篇 |
2016年 | 1156篇 |
2015年 | 1532篇 |
2014年 | 1804篇 |
2013年 | 2068篇 |
2012年 | 3078篇 |
2011年 | 3021篇 |
2010年 | 1736篇 |
2009年 | 1523篇 |
2008年 | 2098篇 |
2007年 | 1948篇 |
2006年 | 1699篇 |
2005年 | 1576篇 |
2004年 | 1204篇 |
2003年 | 1055篇 |
2002年 | 897篇 |
2001年 | 793篇 |
2000年 | 729篇 |
1999年 | 518篇 |
1998年 | 223篇 |
1997年 | 140篇 |
1996年 | 126篇 |
1995年 | 97篇 |
1994年 | 112篇 |
1993年 | 86篇 |
1992年 | 154篇 |
1991年 | 161篇 |
1990年 | 181篇 |
1989年 | 141篇 |
1988年 | 127篇 |
1987年 | 113篇 |
1986年 | 97篇 |
1985年 | 65篇 |
1984年 | 43篇 |
1983年 | 39篇 |
1982年 | 28篇 |
1981年 | 36篇 |
1979年 | 23篇 |
1978年 | 24篇 |
1977年 | 25篇 |
1975年 | 18篇 |
1974年 | 17篇 |
1970年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Geun-Shik Lee Hoe-Jin Kim Yong-Woo Jung Kyung-Chul Choi Eui-Bae Jeung 《Toxicological sciences》2005,84(2):270-277
It has been demonstrated in our previous studies that Calbindin-D9k (CaBP-9k) is a potent biomarker for screening estrogen-like chemicals in the rat model. Although treatments with 17beta-estradiol (E2) and endocrine disrupting compounds resulted in the up-regulation of uterine CaBP-9k, the mechanism of CaBP-9k induction by these compounds through two subtypes of estrogen receptors (ERalpha and ERbeta) is unclear. Thus, in the present study, immature rats were treated with propyl pyrazole triol (PPT, an ERalpha-selective ligand), diarylpropionitrile (DPN, an ERbeta-selective ligand), E2, or dimethyl sulfoxide (DMSO, a vehicle control) for three days in order to clarify which subtype of ER is involved in the uterine CaBP-9k induction. Following injection with these ER ligands, uterine CaBP-9k expression was analyzed by Northern blot and immunoblot assays. Uterine CaBP-9k expression is mainly mediated by PPT in a dose- and time-dependent manner in immature rats, whereas no significant alteration of the uterine CaBP-9k gene was observed after DPN treatment. In addition, an estrogenicity of PPT in inducing CaBP-9k expression was completely blocked by the anti-estrogen ICI 182,780, implying that uterine CaBP-9k is solely induced by ERalpha. A single treatment with PPT rapidly increased the protein levels of ERalpha and PR, an E2-mediated gene, in these tissues. Taken together, these results indicate that uterine CaBP-9k is induced by E2 and endocrine disrupting chemicals via the ERalpha pathway, but not ERbeta, in the uterus of immature rats. 相似文献
42.
Bryan D Stone Johnny J Choi 《Annals of allergy, asthma & immunology》2002,88(5):532; author reply 532-532; author reply 533
43.
Steven JY Wang Claire Cornick Jacqueline O'Dowd Michael A Cawthorne Jonathan R S Arch 《Lipids in health and disease》2007,6(1):2
Background
Mice that lack acyl CoA:diacylglycerol acyltransferase (Dgat1 -/- mice) are reported to have a reduced body fat content and improved glucose tolerance and insulin sensitivity. Studies so far have focussed on male null mice fed a high fat diet and there are few data on heterozygotes. We compared male and female Dgat1 -/-, Dgat1 +/- and Dgat1 +/+ C57Bl/6 mice fed on either standard chow or a high fat diet. 相似文献44.
Duk Hyun Sung Joon Young Choi Du-Hwan Kim Eun-Sang Kim Young-Ik Son Young-Seok Cho Su Jin Lee Kyung-Han Lee Byung-Tae Kim 《Journal of nuclear medicine》2007,48(11):1790-1795
The purpose of this study was to investigate whether (18)F-FDG PET/CT is useful for localizing dystonic cervical muscles in patients with idiopathic cervical dystonia (ICD) by comparing disease severity before and disease severity after botulinum toxin (BT) injection into hypermetabolic muscles. METHODS: Six patients with ICD underwent (18)F-FDG PET/CT. Dystonic muscles suitable for BT injection therapy were defined as those showing diffusely increased (18)F-FDG uptake. RESULTS: Hypermetabolic cervical muscles were identified in all 6 patients. In 2 patients who underwent PET/CT both in a supine position and in a sitting position during (18)F-FDG uptake, abnormal hypermetabolic muscles were observed by PET/CT only when patients were in the sitting position with their heads and necks in the adopted abnormal involuntary posture. Symptoms were significantly improved in 4 patients who underwent BT injection therapy guided by PET/CT and who were clinically monitored. CONCLUSION: (18)F-FDG PET/CT is potentially useful for identifying dystonic cervical muscles for BT therapy in patients with ICD. 相似文献
45.
46.
47.
48.
Gyu-Seog Choi 《Taehan Sohwagi Hakhoe chi》2006,47(4):268-276
For more than a decade, laparoscopic surgery has been adopted as a treatment of colorectal cancer. With promising evidences from multi-center prospective randomized studies, laparoscopic approach is accepted as an alternative for the management of colon cancer. However, laparoscopic surgery is still technically demanding and has little evidence to convince most surgeons of its usefulness for rectal cancer. Laparoscopic surgery for malignant diseases must stress on oncologic safety as well as its functional excellence. Oncologic principles in surgery for rectal cancer are complete resection of the tumor with safe margins, en-bloc resection of regional lymph nodes and appropriate treatment for metastatic lesion. Despite the lack of results in prospective randomized comparative trials, many studies have been investigating whether laparoscopic resection for rectal cancer can follow these principles. In this review, we analyze early outcomes, long-term result of oncologic adequacy in laparoscopic surgery for rectal cancer, and discuss its potential advantages. 相似文献
49.
50.
Airway hyperresponsiveness (AHR) is a characteristic feature of asthma, but is also frequently demonstrated by children and adults with chronic obstructive lung diseases. AHR is usually measured by bronchial challenges using direct or indirect stimuli. The aim of this study was to compare these two types of bronchial challenge in children with post-infectious bronchiolitis obliterans (BO). Methacholine and adenosine 5'-monophosphate (AMP) challenges were used as tools for the evaluation of AHR to direct and indirect stimuli, respectively, in children with post-infectious BO (n = 28). These results were compared with those of asthmatic (n = 30) and control children (n = 25). Altogether, twenty-two patients (78.6%) with post-infectious BO were hyperreactive to methacholine with a provocative concentration causing a 20% fall in forced expiratory volume in one second (PC20) of <16 mg x mL(-1), but only six (21.4%) were hyperreactive to AMP with a PC20 of <200 mg x mL(-1). All patients with asthma responded positively to methacholine, and most (28, 93.3%) also responded positively to AMP. The majority of controls were insensitive to both challenges. Airway hyperresponsiveness to methacholine is a frequent, but by no means universal, finding in children with post-infectious bronchiolitis obliterans, but is usually not accompanied by airway hyperresponsiveness to adenosine 5'-monophosphate. This finding suggests that airway hyperresponsiveness in patients with post-infectious bronchiolitis obliterans has characteristics that differ from those of asthmatic subjects. 相似文献