全文获取类型
收费全文 | 989篇 |
免费 | 98篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 75篇 |
妇产科学 | 32篇 |
基础医学 | 91篇 |
口腔科学 | 36篇 |
临床医学 | 166篇 |
内科学 | 210篇 |
皮肤病学 | 27篇 |
神经病学 | 47篇 |
特种医学 | 156篇 |
外科学 | 70篇 |
综合类 | 25篇 |
预防医学 | 63篇 |
眼科学 | 12篇 |
药学 | 56篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 2篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 21篇 |
2017年 | 23篇 |
2016年 | 25篇 |
2015年 | 28篇 |
2014年 | 36篇 |
2013年 | 42篇 |
2012年 | 16篇 |
2011年 | 28篇 |
2010年 | 41篇 |
2009年 | 67篇 |
2008年 | 30篇 |
2007年 | 47篇 |
2006年 | 19篇 |
2005年 | 25篇 |
2004年 | 11篇 |
2003年 | 15篇 |
2002年 | 10篇 |
2001年 | 21篇 |
2000年 | 14篇 |
1999年 | 23篇 |
1998年 | 72篇 |
1997年 | 82篇 |
1996年 | 57篇 |
1995年 | 51篇 |
1994年 | 37篇 |
1993年 | 43篇 |
1992年 | 14篇 |
1991年 | 9篇 |
1990年 | 12篇 |
1989年 | 26篇 |
1988年 | 22篇 |
1987年 | 27篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1978年 | 5篇 |
1977年 | 11篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1934年 | 1篇 |
1931年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有1133条查询结果,搜索用时 15 毫秒
51.
52.
ObjectiveThis meta-evaluation aimed to summarize all available evidence regarding different fissure sealants on occlusal caries prevention, arrest, retention rate, adverse effect, and cost-effectiveness; when compared with no intervention, other preventive or minimally-invasive procedures.Materials and MethodsThe systematic reviews and meta-analyses were identified via four electronic databases and manual searching. Two independent reviewers performed study selection, data extraction, quality assessment with AMSTAR-2.ResultsAmong the 366 records yielded, 38 systematic reviews were identified as eligible 24 of them included meta-analyses. Moderate evidence has supported the efficacies of resin-based sealants (RBS) in occlusal caries prevention, arrest and cost-effectiveness compared to no interventions. Low to very low certainty of evidence suggested similar effectiveness of glass-ionomer cements in caries prevention with RBS and more superior performance of resin infiltration in arresting non-cavitated occlusal lesions.ConclusionThis meta-evaluation supports the use of RBS on permanent molars to reduce occlusal caries occurrence, arrest lesion progression and alleviate oral health inequalities between individuals of different socioeconomic status. This meta-evaluation also advocates further research on glass-ionomer cements and resin infiltration with respect to their efficacies in caries prevention and arrest. 相似文献
53.
Dr. Mary Fanning MD PhD FRCP Marc Monte MD Lloyd R. Sutherland MDCM FRCPC FACP MSc Mary Broadhead RN ONC Gerard F. Murphy MD CM MSc Alan G. Harris MD 《Digestive diseases and sciences》1991,36(4):476-480
Seventeen AIDS patients were enrolled in a prospective open-label dose-finding study of octreotide (Sandostatin) therapy for refractory diarrhea. Five were nonevaluable due to progression of AIDS symptomatology, and one was excluded because of lack of confirmation of HIV infection. Five of 11 evaluable patients responded to therapy (45%); two each at 50 g and 100 g, and one at 250 g thrice daily doses. A sixth patient demonstrated a moderate reduction in stool volume at 250 g thrice daily, which, although deemed clinically relevant, did not meet the criteria for response. On discontinuation of therapy, diarrhea recurred in all patients within 1–12 days, and responded to reinitiation of octreotide in those five patients who resumed treatment. Only one of the three patients with concurrent cryptosporidial infection responded to treatment. The drug was well tolerated, with mild symptomatology in three patients. Long-term treatment at a stable dose was effective in three of five treated patients for periods for seven months in one (moderate responder) and one year in two. One patient required dose increases to control symptoms, but after one year of treatment developed severe nausea following injections, which required dose cessation. One patient had partial control of his diarrhea for only three months despite two dose increases. These data suggest that octreotide may be of useful therapeutic value in HIV-associated diarrhea and that further studies are indicated.This study was supported by Sandoz Canada Inc. 相似文献
54.
We have previously reported that lithium chloride (LiCl) stimulates the production of granulocyte-macrophage colony-forming cells (GM-CFC), pluripotent stem cells (CFU-S), and differentiated granulocytes, macrophages and megakaryocytes in murine Dexter marrow cultures and that this effect appears to be mediated indirectly by a radioresistant adherent marrow cell. In this study we have established that exposure of murine Dexter cultures to LiCl (4 mEq/L) causes an increase of colony-forming cell megakaryocytes (CFU-meg) over 1 to 6 weeks of culture in both supernatant (188% to 611%) and stromal phases (123% to 246%). Moreover, we have shown that lithium treatment of either irradiated (1,100 rad) or unirradiated stromal cells increased production of activities stimulating formation of megakaryocyte, granulocyte, macrophage, and mixed lineage colonies and proliferation of the factor-dependent cell line, FDC-P1. This FDC-P1 stimulatory activity was completely blocked by an antibody to purified recombinant granulocyte-macrophage colony stimulating factor (rGM-CSF). The baseline or lithium-induced--stromal-derived bone marrow colony stimulating activity was partially blocked by the antibody to rGM-CSF and by an antibody to purified colony stimulating factor I (CSF-1); the two antibodies combined resulted in greater than 90% inhibition of the lithium-induced marrow stimulatory activity. In addition, radioimmunoassay (RIA) showed that although CSF-1 was detectable in supernatants of these cultures, exposure to lithium did not increase CSF-1 levels. These data indicate that Dexter stromal cells produce CSF- 1 and GM-CSF and that lithium appears to exert its stimulatory effects on in vitro myelopoiesis by inducing production of GM-CSF. 相似文献
55.
Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development
下载免费PDF全文
![点击此处可从《Oral diseases》网站下载免费的PDF全文](/ch/ext_images/free.gif)
56.
57.
Nicola Diviani Bas van den Putte Stefano Giani Julia CM van Weert 《Journal of medical Internet research》2015,17(5)
Background
Recent years have witnessed a dramatic increase in consumer online health information seeking. The quality of online health information, however, remains questionable. The issue of information evaluation has become a hot topic, leading to the development of guidelines and checklists to design high-quality online health information. However, little attention has been devoted to how consumers, in particular people with low health literacy, evaluate online health information.Objective
The main aim of this study was to review existing evidence on the association between low health literacy and (1) people’s ability to evaluate online health information, (2) perceived quality of online health information, (3) trust in online health information, and (4) use of evaluation criteria for online health information.Methods
Five academic databases (MEDLINE, PsycINFO, Web of Science, CINAHL, and Communication and Mass-media Complete) were systematically searched. We included peer-reviewed publications investigating differences in the evaluation of online information between people with different health literacy levels.Results
After abstract and full-text screening, 38 articles were included in the review. Only four studies investigated the specific role of low health literacy in the evaluation of online health information. The other studies examined the association between educational level or other skills-based proxies for health literacy, such as general literacy, and outcomes. Results indicate that low health literacy (and related skills) are negatively related to the ability to evaluate online health information and trust in online health information. Evidence on the association with perceived quality of online health information and use of evaluation criteria is inconclusive.Conclusions
The findings indicate that low health literacy (and related skills) play a role in the evaluation of online health information. This topic is therefore worth more scholarly attention. Based on the results of this review, future research in this field should (1) specifically focus on health literacy, (2) devote more attention to the identification of the different criteria people use to evaluate online health information, (3) develop shared definitions and measures for the most commonly used outcomes in the field of evaluation of online health information, and (4) assess the relationship between the different evaluative dimensions and the role played by health literacy in shaping their interplay. 相似文献58.
59.
60.