首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3025895篇
  免费   262461篇
  国内免费   13359篇
耳鼻咽喉   41443篇
儿科学   95543篇
妇产科学   76039篇
基础医学   495746篇
口腔科学   81251篇
临床医学   273052篇
内科学   523403篇
皮肤病学   85032篇
神经病学   258462篇
特种医学   118456篇
外国民族医学   100篇
外科学   473649篇
综合类   94156篇
现状与发展   23篇
一般理论   2113篇
预防医学   256167篇
眼科学   69417篇
药学   205702篇
  23篇
中国医学   9731篇
肿瘤学   142207篇
  2022年   22956篇
  2021年   54750篇
  2020年   34987篇
  2019年   57873篇
  2018年   70314篇
  2017年   53539篇
  2016年   58897篇
  2015年   73460篇
  2014年   107513篇
  2013年   172462篇
  2012年   80386篇
  2011年   78682篇
  2010年   113697篇
  2009年   118699篇
  2008年   65945篇
  2007年   67546篇
  2006年   78851篇
  2005年   74079篇
  2004年   76415篇
  2003年   67440篇
  2002年   57548篇
  2001年   85180篇
  2000年   77122篇
  1999年   80583篇
  1998年   63061篇
  1997年   61293篇
  1996年   59001篇
  1995年   54530篇
  1994年   48708篇
  1993年   45486篇
  1992年   54368篇
  1991年   52188篇
  1990年   49268篇
  1989年   49441篇
  1988年   45700篇
  1987年   44461篇
  1986年   42270篇
  1985年   42809篇
  1984年   41083篇
  1983年   38186篇
  1982年   38928篇
  1981年   36981篇
  1980年   34965篇
  1979年   32865篇
  1978年   30797篇
  1977年   28627篇
  1976年   26286篇
  1975年   24900篇
  1974年   24654篇
  1973年   23524篇
排序方式: 共有10000条查询结果,搜索用时 68 毫秒
991.
992.
Background: Before implementation of the new scale, the Swedish modified version of the Postural Assessment Scale for Stroke Patients (SwePASS), to clinical practice, it is fundamental to analyze its measurement properties.Objective: To examine the inter-rater reliability of the SwePASS in the acute phase after stroke.

Methods: Day 3 to day 7 after admission to a stroke unit, 64 persons with stroke were assessed twice, using the SwePASS, by two physiotherapists. Inter-rater reliability was determined using percentage-agreement and the rank-invariant method: relative position, relative concentration, and relative rank variance.

Results: The raters showed a percentage agreement of ≥75% in the assessments using the SwePASS. For 9 of the 12 items, the percentage agreement was >80%. For 8 of the 12 items, there was a statistically significant change in position, revealed in relative position values between 0.08 and 0.15. Three items had statistically significant positive relative concentration values between ?0.11 and 0.10. Except for a statistically significant negligible relative variance value of 0.01 for the items 1 and 8, there was no relative variance.

Conclusions: The SwePASS shows an acceptable inter-rater reliability, albeit with potential for improvement. The reliability can be improved by a consensus how to interpret the scale between the raters prior to implementation in the clinic.  相似文献   

993.
994.
995.
996.
997.
998.
999.

Background

Clear cell renal cell carcinoma (ccRCC) is known to occur across the adult lifetime traversing the spectrum of age-related organismal changes. Little is known as to how the aging process may affect the course of renal cell carcinoma (RCC) and the repertoire of genes involved.

Methods

Using The Cancer Genome Atlas (n?=?436) and Cancer Genomics of the Kidney (n?=?89) datasets, we applied regression analysis to examine associations between patient age and gene expression profiles in ccRCC tumors and normal kidney tissues. Pathway enrichment analysis was performed to identify cellular process that is affected by aging in ccRCC. Moreover, connectivity mapping analysis was used to predict age-dependent response to drug treatments.

Results

Our analysis revealed different age-dependent gene expression spectra in ccRCC and normal kidney tissues. These findings were significant and independently reproducible in both datasets examined. Age up-regulated genes, showing higher expression in older patients, were significantly enriched (false discovery rate <0.05) in normal tissues for pathways associated with immune response and extracellular matrix organization, whereas age up-regulated genes in tumors were enriched for metabolism and oxidation pathways. Strikingly, age down-regulated genes in normal cells were also enriched for metabolism and oxidation, while those in tumors were enriched for extracellular matrix organization. Further in silico analysis of potential drug targets predicted preferential efficacy of Phosphoinositide 3-kinase inhibitor or immunotherapy in association with age.

Conclusion

We report on previously unrecognized associations between age and molecular underpinnings of RCC, including age-associated expression of genes implicated in RCC development or treatment.  相似文献   
1000.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号