ObjectiveTo explore the clinical value of serum IgM and IgG to SARS‐CoV‐2 in COVID‐19.Methods105 COVID‐19 patients were enrolled as the disease group. 197 non‐COVID‐19 patients served as the control group. Magnetic chemiluminescent immunoassay (MCLIA) was used to detect the IgM and IgG.ResultsThe peak of positive rates of SARS‐CoV‐2 IgM was about 1 week earlier than that of IgG. It reached to peak within 15–21 days and then began a slowly decline. The positive rates of IgG were increased with the disease course and reached the peak between 22 and 39 days. The differences in sensitivity of the three detection modes (IgM, IgG, and IgM + IgG) were statistically significant. The largest group of test cases (illness onset 15–21 days) showed that the positive rate of IgG was higher than IgM. Also, the sensitivity of IgM combined with IgG was higher than IgM or IgG. IgM and IgG were monitored dynamically for 16 patients with COVID‐19, the results showed that serological transformation of IgM was carried out simultaneously with IgG in seven patients, which was earlier than IgG in four patients and later than IgG in five patients.ConclusionThe detection of SARS‐CoV‐2 IgM and IgG is very important to determine the course of COVID‐19. Nucleic acid detection combined with serum antibody of SARS‐CoV‐2 may be the best laboratory indicator for the diagnosis of SARS‐CoV‐2 infection and the phrase and predication for prognosis of COVID‐19. 相似文献
A narrow‐bandgap conjugated polymer, PFDTBTzQ‐2OC1, is prepared by alternating [1,2,3]triazolo[4,5‐g]quinoxaline and 9,9‐didodecyl‐fluorene. With a bandgap of 1.63 eV, this polymer has wide absorption ranging from 300–760 nm in film. Bulk heterojunction solar cells fabricated by blending PFDTBTzQ‐2OC1 with [6,6]‐phenyl‐C71‐butyric acid methyl ester exhibit a maximum power conversion efficiency of 1.31%, with a short‐circuit current density of 1.98 mA cm–2, an open‐circuit voltage of 0.74 V, and a fill factor of 0.47.
A new alternating conjugated polymer (PTCDPP) of carbazole‐substituted triarylamine and diketopyrrolopyrrole is prepared and characterized in detail. The polymer exhibits two strong absorption bands at 345 and 600 nm. With highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of ?5.13 eV and ?3.67 eV, PTCDPP displays an energy gap of 1.66 eV. PTCDPP‐based bulk heterojunction solar cells with a structure of fluorinated tin oxide (FTO)/TiO2/PTCDPP:[6,6]‐phenyl‐C61‐butyric acid methyl ester (PCBM)/MoO3/Ag are fabricated. The devices are optimized by adjusting the composition of the PTCDPP:PCBM active layer, thermal treatment, and addition of processing additives. The device based on PTCDPP:PCBM (1:4, w/w) shows a power conversion efficiency (PCE) of 2.31%, with a short‐circuit current of 4.17 mA cm?2, an open‐circuit voltage of 0.79 V, and a fill factor of 0.35. The best cell performance (2.65% PCE) is achieved by using 1,8‐diiodooctane (3%, v/v) as a processing additive and annealing the active layer at 80 °C.
By establishing an effective ultraviolet B (UVB) radiation model of skin damage in mice, the effect of lemon peel flavonoids (LPF) on skin damage was explored. UVB skin damage in UV-irradiated mice was simulated, and animal models were established. Serum parameters were measured using kits, skin sections were stained with hematoxylin–eosin (H&E) and Masson, and quantitative polymerase chain reaction (qPCR) was used to detect the expression of skin tissue-related mRNA. The experimental results showed that LPF increased the activity of catalase (CAT) and superoxide dismutase (SOD) oxidases in serum of mice with UVB-induced skin damage and decreased MDA, interleukin-1β (IL-1β), IL-6, IL-10, and tumor necrosis factor-alpha (TNF-α) levels. Pathological observation indicated that LPF alleviated the skin tissue lesions caused by UVB. LPF upregulated the mRNA expression of SOD1, SOD2, CAT, nuclear factor erythroid-2 related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and inhibitor of NF-κB alpha (IκB-α) and downregulated the expression of nuclear factor kappa B (NF-κB), p38 MAPK, and cyclooxygenase-2 (COX-2) in the skin tissue of skin-damaged mice. There was a greater protective effect of LPF on the skin as compared to vitamin C (VC) at the same application concentration, and the effect of LPF was positively correlated with the concentration. High performance liquid chromatography (HPLC) analysis showed that LPF contained five flavonoid compounds, namely isomangiferin, rutin, astragalin, naringin, and quercetin. We demonstrated that flavonoids from LPF exhibit an excellent skin protection effect with satisfactory application value.By establishing an effective ultraviolet B (UVB) radiation model of skin damage in mice, the effect of lemon peel flavonoids (LPF) on skin damage was explored.相似文献
We report a case of aseptic abscess in the cavernous body at the base of the penis.In our clinical observation,the patient underwent puncture and drainage of the corpus cavernosum abscess,followed by surgical resection of the abscess wall,with the incisions closed layer by layer with primary suture.In addition,we paid attention to strengthening the postoperative management by using elastic bandages to wrap the penis intermittently to prevent edema;the incision would not be covered with dressings from the third day after the operation,so as to keep the incision site dry in an open way.During the period of indwelling of the catheter after the operation,we noticed the care of the external orifice of the urethra to reduce the occurrence of catheter-related infections.Finally,the patient was diagnosed with a penile aseptic abscess in the cavernous body at the base of the penis.The patient recovered well after surgery and was discharged 1 week later.At 1.5 years after the operation,the shape of the penis returned to normal,and the erectile function was normal.It was seen that good nursing concept is of great help for prognosis,which could avoid infection and edema,and is conducive to wound healing. 相似文献