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361.
Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface.
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362.
Baiocchi G Faloppa CC Osório CA Kumagai LY Fukazawa EM Cunha IW 《The journal of obstetrics and gynaecology research》2011,37(7):940-946
Embryonal rhabdomyosarcoma (RMS) of the female genital tract usually occurs in the vagina during childhood. The uterine cervix as a primary site is rare, but is more frequent until the second decade of life. It usually has a good prognosis and the treatment is based on multidrug chemotherapy, radiotherapy and surgery. RMS accounts for <5% of all adult soft tissue sarcomas. Previous reports that included all primary sites showed a poorer five-year disease specific survival for adults with RMS when compared to the pediatric population. This difference has been attributed to a higher proportion of adverse prognostic clinical and pathological factors, and to inadequate treatment given to adults with RMS. A total of 115 patients with cervical embryonal RMS have previously been described; however, only 10 cases were reported in women older than 40 years. We present a 47-year-old woman treated with radical hysterectomy followed by adjuvant chemotherapy and review the current literature. 相似文献
363.
Baiocchi OC Colleoni GW Rodrigues CA Barton D Kerbauy FR Garcia RJ Segreto RA Alves AC Bordin JO 《Leukemia & lymphoma》2003,44(10):1837-1839
Primary bone lymphoma (PBL) is a rare entity and comprises about 5% of all extranodal non-Hodgkin's lymphomas (NHL) and 7% of all primary bone tumors. To date there is no consensus about the optimal treatment for PBL. We retrospectively reviewed all cases of PBL treated at Hospital S?o Paulo, Brazil, over a 10-year-period (January 1992-January 2002). Medical records of 7 patients with PBL were reviewed and information on age at diagnosis, sex, NHL clinical staging (CS), treatment and response to treatment were retrieved. Five patients (72%) received combined-modality therapy (CMT) and all of them are in complete remission (CR) with a median follow up of 19 months (ranging from 12 to 144 months). We conclude that PBL is a potentially curable malignancy and treatment should be undertaken in a multiprofessional approach, in order to provide the best support which probably has to include chemotherapy, radiotherapy and, for patients with IPI higher than 2, consolidation with stem-cell transplantation. 相似文献
364.
Lara C. Burg Shenna Verheijen Ruud L.M. Bekkers Joanna IntHout Robert W. Holloway Salih Taskin Sarah E. Ferguson Yu Xue Antonino Ditto Glauco Baiocchi Andrea Papadia Giorgio Bogani Alessandro Buda Roy F.P.M. Kruitwagen Petra L.M. Zusterzeel 《Journal Of Gynecologic Oncology》2022,33(5)
ObjectiveThe aim of this study was to assess the SLN detection rate in presumed early stage, low- and intermediate-risk endometrial cancers, the incidence of SLN metastases, and the negative predictive value of SLN mapping performed with indocyanine green (ICG).MethodsA systematic review with meta-analyses was conducted. Study inclusion criteria were A) low- and intermediate-risk endometrial cancer, B) the use of ICG per cervical injection; C) a minimum of twenty included patients per study. To assess the negative predictive value of SLN mapping, D) a subsequent lymphadenectomy was an additional inclusion criterion.ResultsFourteen studies were selected, involving 2,117 patients. The overall and bilateral SLN detection rates were 95.6% (95% confidence interval [CI]=92.4%–97.9%) and 76.5% (95% CI=68.1%–84.0%), respectively. The incidence of SLN metastases was 9.6% (95% CI=5.1%–15.2%) in patients with grade 1–2 endometrial cancer and 11.8% (95% CI=8.1%–16.1%) in patients with grade 1–3 endometrial cancer. The negative predictive value of SLN mapping was 100% (95% CI=98.8%–100%) in studies that included grade 1–2 endometrial cancer and 99.2% (95% CI=97.9%–99.9%) in studies that also included grade 3.ConclusionSLN mapping with ICG is feasible with a high detection rate and negative predictive value in low- and intermediate-risk endometrial cancers. Given the incidence of SLN metastases is approximately 10% in those patients, SLN mapping may lead to stage shifting with potential therapeutic consequences. Given the high negative predictive value with SLN mapping, routine lymphadenectomy should be omitted in low- and intermediate-risk endometrial cancer. 相似文献
365.
Ja-Young Jang Inah Hwang Heng Pan Jun Yao Lapo Alinari Eddie Imada Claudio Zanettini Michael J. Kluk Yizhe Wang Yunkyoung Lee Hua V. Lin Xiangao Huang Maurizio Di Liberto Zhengming Chen Karla V. Ballman Lewis C. Cantley Luigi Marchionni Giorgio Inghirami Olivier Elemento Robert A. Baiocchi Selina Chen-Kiang Sandro Belvedere Hongwu Zheng Jihye Paik 《The Journal of clinical investigation》2022,132(24)
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Cristina Aurigemma MD PhD Carlo Trani MD Paola D'Errigo MSc Marco Barbanti MD PhD Fausto Biancari MD Giuseppe Tarantini MD PhD Gennaro Santoro MD Massimo Baiocchi MD Giovanni Baglio Fulvia Seccareccia MSc Stefano Rosato MSc the OBSERVANT II Research Group 《Catheterization and cardiovascular interventions》2023,102(2):381-391