全文获取类型
收费全文 | 3326篇 |
免费 | 117篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 62篇 |
妇产科学 | 58篇 |
基础医学 | 421篇 |
口腔科学 | 86篇 |
临床医学 | 194篇 |
内科学 | 737篇 |
皮肤病学 | 75篇 |
神经病学 | 187篇 |
特种医学 | 86篇 |
外科学 | 608篇 |
综合类 | 8篇 |
预防医学 | 107篇 |
眼科学 | 39篇 |
药学 | 173篇 |
中国医学 | 8篇 |
肿瘤学 | 584篇 |
出版年
2023年 | 15篇 |
2022年 | 34篇 |
2021年 | 61篇 |
2020年 | 35篇 |
2019年 | 42篇 |
2018年 | 51篇 |
2017年 | 44篇 |
2016年 | 58篇 |
2015年 | 67篇 |
2014年 | 81篇 |
2013年 | 108篇 |
2012年 | 208篇 |
2011年 | 186篇 |
2010年 | 133篇 |
2009年 | 99篇 |
2008年 | 171篇 |
2007年 | 181篇 |
2006年 | 156篇 |
2005年 | 200篇 |
2004年 | 192篇 |
2003年 | 157篇 |
2002年 | 163篇 |
2001年 | 104篇 |
2000年 | 124篇 |
1999年 | 106篇 |
1998年 | 36篇 |
1997年 | 35篇 |
1996年 | 34篇 |
1995年 | 21篇 |
1994年 | 25篇 |
1993年 | 20篇 |
1992年 | 69篇 |
1991年 | 39篇 |
1990年 | 44篇 |
1989年 | 26篇 |
1988年 | 32篇 |
1987年 | 32篇 |
1986年 | 25篇 |
1985年 | 34篇 |
1984年 | 18篇 |
1983年 | 17篇 |
1980年 | 9篇 |
1979年 | 13篇 |
1978年 | 17篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1972年 | 20篇 |
1970年 | 20篇 |
1968年 | 15篇 |
1967年 | 8篇 |
排序方式: 共有3456条查询结果,搜索用时 31 毫秒
81.
Hasegawa D Fukushima M Hosokawa Y Takeda H Kawasaki K Mizukami T Nunoi H Ochiai H Morio T Kosaka Y 《International journal of hematology》2008,87(1):88-90
Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity
conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also
been reported to increase the risk of unsustained mixed donor chimerism and late rejection after transplantation. Herein,
we report a 4-year-old boy with CGD who was successfully treated with unrelated bone marrow transplantation with a reduced-intensity
conditioning regimen (RIC). Fludarabine-based RIC, 4 Gy of total body irradiation, 120 mg/kg of cyclophosphamide, and 125 mg/m2 of fludarabine, was adopted for transplantation, followed with 8.9 × 108/kg mononucleated donor cells infused without T-cell depletion. Although hematopoietic engraftment was rapidly obtained by
day +17, he developed unstable donor chimerism. After tacrolimus withdrawal, the patient showed grade III acute graft-versus-host
disease (GVHD), and subsequently reached full donor chimerism by day +61. Twelve months post-transplant, the patient has remained
well with stable and durable engraftment, 100% donor chimerism, and normal superoxide production, without the requirement
of donor lymphocyte infusions (DLI). 相似文献
82.
83.
Muhammad Farooq Hiroyuki Nakai Atsushi Fujimoto Hiroki Fujikawa Asako Matsuyama Naoyuki Kariya Atsuko Aizawa Hiroshi Fujiwara Masaaki Ito Yutaka Shimomura 《Human mutation》2013,34(1):176-183
Generalized pustular psoriasis (GPP) is a rare, potentially life threatening, and aggressive form of psoriasis, which is characterized by sudden onset with repeated episodic skin inflammation leading to pustule formation. Familial GPP is known to be caused by recessively inherited mutations in the IL36RN gene, which encodes interleukin 36 receptor antagonist (IL‐36Ra). In this article, we performed mutation analysis of the IL36RN gene in 14 Japanese patients with GPP, and identified mutations in two of these patients analyzed. One patient was compound heterozygous for mutations c.115+6T>C and c.368C>G (p.Thr123Arg), whereas the other carried compound heterozygous mutations c.28C>T (p.Arg10*) and c.115+6T>C in the IL36RN gene. Expression studies using total RNA from the patients’ skin revealed that the mutation c.115+6T>C resulted in skipping of exon 3, leading to a frameshift and a premature termination codon (p.Arg10Argfs*1). The protein structure analysis suggested that the missense mutation p.Thr123Arg caused misfolding and instability of IL‐36Ra protein. In vitro studies in cultured cells showed impaired expression of the p.Thr123Arg mutant IL‐36Ra protein, which failed to antagonize the IL‐36 signaling pathway. Our data further underscore the critical role of IL36RN in pathogenesis of GPP. 相似文献
84.
85.
86.
Inflammatory pseudotumor of the liver diagnosed by needle liver biopsy under ultrasonographic tomography guidance 总被引:7,自引:0,他引:7
Nakama T Hayashi K Komada N Ochiai T Hori T Shioiri S Tsubouchi H 《Journal of gastroenterology》2000,35(8):641-645
Inflammatory pseudotumor of the liver is a rare benign lesion, but exploratory laparotomy and a hepatectomy are often performed
unnecessarily after various misdiagnoses, including liver abscess, hepatocellular carcinoma, metastatic liver tumor, and cholangiocarcinoma.
We present a case of hepatic inflammatory pseudotumor in a 17-year-old man in whom diagnosis was confirmed by liver needle
biopsy under ultrasonographic tomography (UST) guidance. He had complained of fever and right hypochondralgia 2 months after
being operated for appendicitis. He was admitted to our hospital because of the persistence of these symptoms and the presence
of a hepatic mass lesion detected by UST. He had hepatomegaly, with tenderness; leukocytosis and elevated erythrocyte sedimentation
rate and C-reactive protein level were noted. UST showed a hypoechoic mass in the liver and pre-contrast computerized tomography
(CT) revealed a low-density area with an ill defined margin, which was barely enhanced by the contrast medium. On the basis
of the patient's clinical symptoms and the laboratory data and imaging studies, the presence of a liver abscess was suspected
and antibiotics were administered. One month after the initiation of the antibiotic therapy, UST demonstrated that the portal
vein had dilated serpiginously and penetrated into the mass. As the heterogeneous appearance displayed by post-enhanced CT
indicated the need for a differential diagnosis of the hepatic mass lesion to rule out hepatocellular carcinoma, percutaneous
needle biopsy was performed, under UST guidance. Histopathological examination demonstrated marked infiltration of plasma
cells and fibrosis, findings which were consistent with those of hepatic inflammatory pseudotumor. There was a spontaneous
reduction of the hepatic pseudotumor without continuous antibiotics and this reduction was documented on follow-up UST and
CT.
Received: June 30, 1999 / Accepted: December 17, 1999 相似文献
87.
K Kamei T Funabiki M Ochiai H Amano Y Marugami M Kasahara T Sakamoto 《International journal of pancreatology》1992,11(2):97-104
Five cases of pancreatic serous cystadenoma were examined pathologically, and their nuclear DNA ploidy patterns were determined. Four were unifocal tumors, and one was a multifocal tumor. The four unifocal tumors were typical serous cystadenomas. However, the multifocal tumor exhibited an increased N/C ratio, irregular nuclear margins, various-sized nuclei, coarse nuclear chromatin, and neural invasion. All tumor cells were stained with antiCA19-9 but none with antiCEA. In the antiCA19-9 staining, the four unifocal tumors and the tumors of the pancreatic tail in the multifocal case were positive only on the apical membrane, whereas the tumor cells of the pancreatic head in the multifocal case were positive within the whole cytosol. The unifocal tumors were diploid with a DNA Index (DI) of 1.0 and proliferation indices (PI) from 4.9 to 20.9% with a mean of 14.4%. In the multifocal case, the tumor in the pancreatic head was aneuploid (DI = 1.9) and had a PI of 27.8%. The multifocal sites in the pancreatic body were aneuploid (DI = 1.9) with a PI of 22.4%. We suggest that the biological property of serous cystadenoma should be revisited. 相似文献
88.
Daisuke Ban Atsushi Kudo Takumi Irie Takanori Ochiai Arihiro Aihara Satoshi Matsumura Shinji Tanaka Minoru Tanabe 《Asian journal of endoscopic surgery》2015,8(1):11-15
Reduced port surgery has been attracting attention in the field of minimally invasive surgery. Although the use of SILS is becoming widespread, technical difficulty has delayed its adoption for laparoscopic liver resection. Recently, advances in laparoscopic liver resection have been made in tandem with advances in surgical skill and devices. The main driver in conventional laparoscopic liver resection's evolution to become less surgically invasive seems to be single‐incision laparoscopic liver resection (SILLR). To date, most reports on SILLR have been single case reports or case series. Only a few cohort studies on conventional laparoscopic surgery and SILLR have been conducted. Recent reports have described the use of SILLR for well‐localized lesions and solitary tumors located in the anterolateral segments of the liver or left liver lobe, but its application remains limited to partial resection and left lateral sectionectomy. The feasibility and safety of SILLR have been demonstrated, but additional work is needed for standardization of the procedure. 相似文献
89.
Treatment strategy for Boerhaave''s syndrome 总被引:5,自引:0,他引:5
T. Ochiai S. Hiranuma N. Takiguchi K. Ito M. Maruyama T. Nagahama T. Kawano K. Nagai T. Nishikage N. Noguchi S. Takamatsu T. Kawamura K. Teramoto T. Iwai S. Arii 《Diseases of the esophagus》2004,17(1):98-103
Esophageal rupture is a potentially mortal condition. Rapid and correct diagnosis, and urgent surgical treatment with esophagectomy is indicated, but conservative and other surgical treatments have also been reported recently. The treatment strategies for esophageal rupture are discussed here, based on our experiences with four cases during the last 10 years. They were admitted urgently and each was treated by a different method. Three of them underwent emergency operations, one undergoing primary closure of the ruptured esophagus, another received a T-tube insertion from the ruptured site with omental flap, and the third an esophagogastrectomy. The fourth case was treated conservatively. All patients survived and were discharged 36-144 days post treatment. One of them was readmitted for debridement of necrotic rib. In conclusion, the prompt and accurate diagnosis of esophageal rupture is crucial for a subsequent successful treatment. Conservative treatment or operation including esophagectomy will be determined by the severity of the condition. 相似文献
90.
A. Shiozaki H. Fujiwara Y. Murayama S. Komatsu Y. Kuriu H. Ikoma M. Nakanishi D. Ichikawa K. Okamoto T. Ochiai Y. Kokuba E. Otsuji 《Diseases of the esophagus》2014,27(5):470-478
This study was designed to determine the efficacy of esophagectomy preceded by the laparoscopic transhiatal approach (LTHA) with regard to the perioperative outcomes of esophageal cancer. The esophageal hiatus was opened by hand‐assisted laparoscopic surgery, and carbon dioxide was introduced into the mediastinum. Dissection of the distal esophagus was performed up to the level of the tracheal bifurcation. En bloc dissection of the posterior mediastinal lymph nodes was performed using LTHA. Next, cervical lymphadenectomy, reconstruction via a retrosternal route with a gastric tube and anastomosis from a cervical approach were performed. Finally, a small thoracotomy (around 10 cm in size) was made to extract the thoracic esophagus and allow upper mediastinal lymphadenectomy to be performed. The treatment outcomes of 27 esophageal cancer patients who underwent LTHA‐preceding esophagectomy were compared with those of 33 patients who underwent the transthoracic approach preceding esophagectomy without LTHA (thoracotomy; around 20 cm in size). The intrathoracic operative time and operative bleeding were significantly decreased by LTHA. The total operative time did not differ between the two groups, suggesting that the abdominal procedure was longer in the LTHA group. The number of resected lymph nodes did not differ between the two groups. Postoperative respiratory complications occurred in 18.5% of patients treated with LTHA and 30.3% of those treated without it. The increase in the number of peripheral white blood cells and the duration of thoracic drainage were significantly decreased by this method. Our surgical procedure provides a good surgical view of the posterior mediastinum, markedly shortens the intrathoracic operative time, and decreases the operative bleeding without increasing major postoperative complications. 相似文献