全文获取类型
收费全文 | 3335篇 |
免费 | 114篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 64篇 |
妇产科学 | 59篇 |
基础医学 | 421篇 |
口腔科学 | 86篇 |
临床医学 | 194篇 |
内科学 | 740篇 |
皮肤病学 | 75篇 |
神经病学 | 187篇 |
特种医学 | 86篇 |
外科学 | 608篇 |
综合类 | 8篇 |
预防医学 | 107篇 |
眼科学 | 39篇 |
药学 | 173篇 |
中国医学 | 8篇 |
肿瘤学 | 584篇 |
出版年
2023年 | 15篇 |
2022年 | 37篇 |
2021年 | 61篇 |
2020年 | 35篇 |
2019年 | 42篇 |
2018年 | 51篇 |
2017年 | 44篇 |
2016年 | 58篇 |
2015年 | 67篇 |
2014年 | 81篇 |
2013年 | 108篇 |
2012年 | 208篇 |
2011年 | 186篇 |
2010年 | 133篇 |
2009年 | 99篇 |
2008年 | 171篇 |
2007年 | 181篇 |
2006年 | 156篇 |
2005年 | 200篇 |
2004年 | 192篇 |
2003年 | 157篇 |
2002年 | 163篇 |
2001年 | 104篇 |
2000年 | 124篇 |
1999年 | 106篇 |
1998年 | 36篇 |
1997年 | 35篇 |
1996年 | 34篇 |
1995年 | 21篇 |
1994年 | 25篇 |
1993年 | 20篇 |
1992年 | 69篇 |
1991年 | 39篇 |
1990年 | 44篇 |
1989年 | 26篇 |
1988年 | 32篇 |
1987年 | 32篇 |
1986年 | 25篇 |
1985年 | 34篇 |
1984年 | 18篇 |
1983年 | 17篇 |
1980年 | 9篇 |
1979年 | 13篇 |
1978年 | 17篇 |
1977年 | 9篇 |
1976年 | 10篇 |
1972年 | 20篇 |
1970年 | 20篇 |
1968年 | 15篇 |
1967年 | 8篇 |
排序方式: 共有3462条查询结果,搜索用时 0 毫秒
101.
Yu Konishi Peter J. McNair David A. Rice Satoshi Ochiai Tetsuo Hagino 《Scandinavian journal of medicine & science in sports》2020,30(12):2342-2351
No studies in ACL-D individuals have examined neuromuscular adaptations during landing from a jump where an unexpected mechanical event changes the pre-programmed course of movement. The purpose of this study was to compare pre- and post-landing muscle activation in ACL-D individuals and uninjured controls during normal and surprise landings. Nineteen ACL-D and 17 uninjured volunteered. Participants performed repeated single leg landings from 30 and 15 cm heights. During 15 cm landings, a single surprise landing was performed where participants unexpectedly fell through a false surface at 15 cm to the solid floor a further 15 cm below. Electromyography (EMG) amplitude from vastus lateralis (VL), lateral hamstrings (LH), and soleus (Sol) was recorded. Pre-landing (−60 to 0 ms), post-landing short latency (31-60 ms), and post-landing medium latency (61-90 ms) periods were examined. Comparisons in EMG amplitudes were made across limbs (ACL-D, ACL intact, and control) in 30 cm landings. Additionally, the ratio of EMG amplitude in surprise:30 cm normal landings was analyzed. Post-landing LH EMG was reduced in the ACL-D compared to control limbs at short latencies (P < 0.05). Post-landing VL EMG was reduced in the ACL-D and ACL intact compared to the control limb at both latencies (P < 0.05). Surprise landings notably increased post-landing EMG in all muscles, across all limbs (P < 0.001). However, the gain in VL EMG was significantly greater in ACL-D and ACL intact limbs (P < 0.05). These changes in neuromuscular control of ACL-D individuals during expected and surprise landings may have important implications for rehabilitation, instability, and the risk of secondary injury. 相似文献
102.
103.
Yoshifumi Kotake Mitsue Fukuda Aya Yamagata Ririko Iwasaki Daisuke Toyoda Nobukazu Sato Ryoichi Ochiai 《Journal of anesthesia》2014,28(2):180-188
Background
This prospective observational study compared the volume effect between hydroxyethyl starch (HES) and crystalloid solution and its context dependency in intraoperative goal-directed fluid management.Methods
With institutional review board (IRB) approval, 35 patients undergoing major gastrointestinal surgery were enrolled. Fluid challenge consisting of 250 ml of either bicarbonate Ringer solution (BRS) or low molecular weight pentastarch (HES 70/0.5) was given to maintain stroke volume index >35 ml/m2. The context of fluid challenge was classified as related to either epidural block (EB) or blood loss (BL) or as nonspecific. The primary end point was the interval between index fluid challenge and the next fluid challenge, and the secondary end point was the hemodynamic parameter at the end of fluid challenge. Differences in these parameters in each clinical context were compared between BRS and HES 70/0.5. A p value <0.05 was considered statistically significant.Results
Eighty-eight, 77, and 127 fluid challenges were classified as related to EB and BL and as nonspecific, respectively. In the nonspecific condition, the median (range) interval after fluid challenge with HES 70/0.5 and BRS was 45 (11–162) min and 18 (8–44) min, respectively, and the difference was statistically significant. Also, mean arterial pressure and stroke volume index significantly increased, whereas stroke volume variation significantly decreased after fluid challenge with HES 70/0.5 compared with BRS. Such differences were not observed in the other situations.Conclusions
HES 70/0.5 exerted larger volume effects than did crystalloid under nonspecific conditions. However, similar volume effects were observed during volume loss and extensive sympathetic blockade. 相似文献104.
Daisuke Toyoda Rie Yasumura Mitsue Fukuda Ryoichi Ochiai Yoshifumi Kotake 《Journal of anesthesia》2014,28(3):463-466
The purpose of this prospective study was to evaluate the accuracy and trending ability of a four-wavelength pulse-total hemoglobinometer that continuously and noninvasively measures hemoglobin in surgical patients. With IRB approval and informed consent, spectrophotometric hemoglobin (SpHb) was measured with a pulse-total hemoglobinometer manufactured by Nihon Kohden Corp (Tokyo, Japan) and compared to the CO-oximeter equipped with blood gas analyzer. Two hundred twenty-five samples from 56 subjects underwent analysis. Bland–Altman analysis revealed that the bias ± precision of the current technology was 0.0 ± 1.4 g/dl and ?0.2 ± 1.3 g/dl for total samples and samples with 8 < Hb < 11 g/dl, respectively. The percentages of samples with intermediate risk of therapeutic error in error grid analysis and the concordance rate of 4-quadrant trending assay was 17 % and 77 %, respectively. The Cohen kappa statistic for Hb < 10 g/dl was 0.38, suggesting that the agreement between SpHb and CO-oximeter-derived Hb was fair. Collectively, wide limits of agreement, especially at the critical level of hemoglobin, and less than moderate agreement against CO-oximeter-derived hemoglobin preclude the use of the pulse-total hemoglobinometer as a decision-making tool for transfusion. 相似文献
105.
Ryuji Ochiai Yoko Sugiura Yasushi Shioya Kazuhiro Otsuka Yoshihisa Katsuragi Teruto Hashiguchi 《Nutrition Research》2014
Brewed coffee is a widely consumed beverage, and many studies have examined its effects on human health. We investigated the vascular effects of coffee polyphenols (CPPs), hypothesizing that a single ingestion of CPP during glucose loading would improve endothelial function. To test this hypothesis, we conducted a randomized acute clinical intervention study with crossover design and measured reactive hyperemia index (RHI) to assess the acute effects of a 75-g glucose load with CPP in healthy, nondiabetic adult men. Blood glucose and insulin levels were elevated after glucose loading with and without CPP, with no significant differences between treatments. The RHI did not significantly decrease after glucose loading without CPP. With CPP, however, RHI significantly (P < .05) increased over baseline after glucose loading. The difference between treatments was statistically significant (P < .05). No significant changes were observed in an oxidative stress marker after glucose loading with or without CPP. These findings suggest that a single ingestion of CPP improves peripheral endothelial function after glucose loading in healthy subjects. 相似文献
106.
Masaru Ochiai Takashi Kuroda Tatsuhiro Matsuo 《International journal of food sciences and nutrition》2014,65(4):495-501
We investigated the fat metabolic characteristics in non-obese and diabetic Goto-Kakizaki (GK) rat and the effects of dietary egg white hydrolysate (EWH) on glucose and fat metabolism. Wistar (W) and GK (G) rats were placed into dietary casein (WC and GC) or EWH (WE and GE) group, and fed their respective diet for six weeks. Triglyceride (TG) content and stearoyl-CoA desaturase (SCD) indices in the soleus muscle were higher in the GC group than WC group in parallel with worsening serum glucose metabolic parameters. The glucose metabolic parameters were significantly improved in the GE group. The TG accumulation and SCD indices in the soleus muscle were also significantly lower in the GE group than in the GC group. In conclusion, dietary EWH not only improved glucose metabolism but also reduced both TG accumulation and SCD indices in the soleus muscle of GK rat. 相似文献
107.
Javier I Quezada-Marín Alfred K Lam Atsushi Ochiai Robert D Odze Kay M Washington Masashi Fukayama Massimo Rugge David S Klimstra Iris D Nagtegaal Puay-Hoon Tan Mark J Arends John R Goldblum Ian A Cree Manuel Salto-Tellez 《Histopathology》2020,77(3):340-350
Molecular biomarkers have come to constitute one of the cornerstones of oncological pathology. The method of classification not only directly affects the manner in which patients are diagnosed and treated, but also guides the development of drugs and of artificial intelligence tools. The aim of this article is to organise and update gastrointestinal molecular biomarkers in order to produce an easy-to-use guide for routine diagnostics. For this purpose, we have extracted and reorganised the molecular information on epithelial neoplasms included in the 2019 World Health Organization classification of tumours. Digestive system tumours, 5th edn. 相似文献
108.
109.
Takayuki Okamoto Yasuyuki Sato Takeshi Yamazaki Asako Hayashi 《European journal of pediatrics》2014,173(4):533-536
Common pathogens of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) are viruses, such as influenza virus. However, bacteria are rare pathogens for MERS. We report the first patient with MERS associated with febrile urinary tract infection. A 16-year-old lupus patient was admitted to our hospital. She had fever, headache, vomiting, and right back pain. Urinary analysis showed leukocyturia, and urinary culture identified Klebsiella pneumoniae. Cerebrospinal fluid examination and brain single-photon emission computed tomography showed no abnormalities. Therefore, she was diagnosed with febrile urinary tract infection. For further examinations, 99mTc-dimercaptosuccinic acid renal scintigraphy showed right cortical defects, and a voiding cystourethrogram demonstrated right vesicoureteral reflux (grade II). Therefore, she was diagnosed with right pyelonephritis. Although treatment with antibiotics administered intravenously improved the fever, laboratory findings, and right back pain, she had prolonged headaches, nausea, and vomiting. T2-weighted, diffusion-weighted, and fluid attenuated inversion recovery images in brain magnetic resonance imaging showed high intensity lesions in the splenium of the corpus callosum, which completely disappeared 1 week later. These results were compatible with MERS. To the best of our knowledge, our patient is the first patient who showed clinical features of MERS associated with febrile urinary tract infection. Conclusion: In patients with pyelonephritis and an atypical clinical course, such as prolonged headache, nausea, vomiting, and neurological disorders, the possibility of MERS should be considered. 相似文献
110.
Tomoro Hishiki Hiroshi Horie Yasuyuki Higashimoto Katsumi Yotsumoto Shugo Komatsu Yuri Okimoto Harumi Kakuda Yuichi Taneyama Takeshi Saito Keita Terui Tetsuya Mitsunaga Mitsuyuki Nakata Hidemasa Ochiai Moeko Hino Kumiko Ando Hideo Yoshida Jun Iwai 《Pediatric surgery international》2014,30(9):919-926