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Barba P Sampol A Calbacho M Gonzalez J Serrano J Martínez-Sánchez P Fernández P García-Boyero R Bueno J Ribera JM 《American journal of hematology》2012,87(6):631-634
The present study reports the Spanish PETHEMA group experience in 31 heavily pretreated relapsed/refractory acute lymphoblastic leukemia (ALL) and lymphoma (LL) patients treated with clofarabine-based regimens. The complete remission (CR) rate was 31% (median CR duration of 3 months [range 2–28]) and the overall survival probability at 1 year was 10% (95%CI 4–16%). Responses were seen in B and T lineage diseases and in patients with adverse cytogenetics. Hematological and infectious grade >3 toxicities were found in 100 and 67% of the patients, respectively, with 7 (23%) treatment-related deaths. Other organ toxicities were infrequent. Clofarabine-based chemotherapy regimens might induce CRs in ALL and LL patients, but hematological toxicity and infections may limit their use in heavily pretreated patients. 相似文献
125.
Daniel L. Pellicer Peter M. Sadow M.D. Ph.D. Antonia Stephen M.D. William C. Faquin M.D. Ph.D 《Diagnostic cytopathology》2013,41(8):706-709
Squamous metaplasia (SM) occurs in a variety of thyroid conditions, both neoplastic and non‐neoplastic. In a small subset of benign thyroid lesions, SM can create a diagnostic pitfall by mimicking a malignant process. Here, we describe the case of a 52‐year‐old male with a 1.5 cm right thyroid nodule. Ultrasound‐guided fine‐needle aspiration biopsy showed markedly atypical, mitotically active epithelial cells which were suspicious for high‐grade carcinoma. Resection of the nodule demonstrated a follicular adenoma with cystic changes and atypical SM of the cyst‐lining component. As illustrated here, SM of the thyroid represents an important diagnostic pitfall for the cytopathologist, and should be included in the differential diagnosis of thyroid nodules, particularly those with potentially benign cystic changes. Diagn. Cytopathol. 2013;41:706–709. © 2013 Wiley Periodicals, Inc. 相似文献
126.
Roy Phitayakorn Dieter Morales-Garcia Jonathan Wanderer Carrie C. Lubitz Randall D. Gaz Antonia E. Stephen Jesse M. Ehrenfeld Gilbert H. Daniels Richard A. Hodin Sareh Parangi 《American journal of surgery》2013
Background
Optimal treatment of Graves’ disease (GD) remains controversial. The authors retrospectively reviewed the surgical cases of GD at a single academic tertiary center.Methods
Demographic, clinical, and surgical data were analyzed for all patients with GD undergoing thyroidectomy over 25 years, in 3 periods: 1985 to 1993 (n = 32), 1994 to 2002 (n = 91), and 2003 to 2010 (n = 177).Results
There were 300 patients with GD (85.7% women; mean age, 39.3 years; median length of follow-up, 24.6 months). Overall, perioperative morbidity occurred in 36 patients (12.0%), and there was no mortality. Thyroidectomy-specific morbidity was very low, and the incidental malignancy rate was 10.3%.Conclusions
Surgical treatment of GD has a very high safety profile, with low perioperative and thyroidectomy-specific morbidity, even in patients with overt hyperthyroidism. Incidental malignancy in patients with GD is not uncommon. 相似文献127.
Antonia Wade Caroline Hayhurst Anthony Amato-Watkins Alistair Lammie Paul Leach 《Acta neurochirurgica》2013,155(8):1431-1435
Background
Pilocytic astrocytoma is one of the commonest subtypes of glioma to affect children. However, they are rarely diagnosed in patients over the age of 18 years. In adults, these tumours appear more frequently supra-tentorially than in the cerebellum and some reports suggest a different clinical course in adults. We reviewed ten patients aged 18 or over who had been operated on for cerebellar pilocytic astrocytoma to assess the impact of tumour biology and extent of resection on outcome in adults.Method
Patients were identified from a neuropathology database and a retrospective chart review of ten patients was performed. Recorded data included patient demographics, tumour location, presenting features, radiological appearance, extent of surgical resection, tumour recurrence and Ki-67 proliferation index.Results
Nine patients were men and one patient was a woman. Median follow up is 41.5 months (range 15–334 months). Complete surgical resection was achieved in nine of the patients operated in our institution. One patient had prior subtotal resection elsewhere. Tumour recurrence was seen only in the two patients with subtotal resection, at 7 and 25 years. Ki-67 ranged from <1 to 10 % and appears to have no correlation to recurrence. No patients in this series had adjuvant treatment.Conclusions
Cerebellar pilocytic astrocytomas in adults should be treated with macroscopic complete surgical resection whenever possible. If this is achieved, long-term survival rates are excellent, whereas subtotal resection carries a high risk of tumour recurrence. Ki-67 is less important prognostically than the extent of initial resection. 相似文献128.
129.
Antonia Barceló Javier Piérola Mónica de la Pe?a Guillem Frontera Aina Ya?ez Alberto Alonso-Fernández Olga Ayllon Alvar G. N. Agusti 《Sleep & breathing》2012,16(2):355-360
Background
Cardiovascular diseases are frequent in patients with obstructive sleep apnea (OSAS). There is evidence that the day–night pattern of myocardial infarction and sudden cardiac death observed in the general population is altered in patients with OSAS. This study investigates potential abnormalities in the circadian profiles of platelet activity in OSAS. 相似文献130.
Blumen MB Quera Salva MA Vaugier I Leroux K d'Ortho MP Barbot F Chabolle F Lofaso F 《Sleep & breathing》2012,16(3):903-907