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401.
402.
K Konieczny TC Biggs S Caldera 《Annals of the Royal College of Surgeons of England》2013,95(6):410-414
IntroductionThe T-14 questionnaire is a validated patient reported outcome measure (PROM) used to assess the value of paediatric tonsillectomy from the patient’s perspective. Tonsillectomy is a procedure under threat. As such, this study aimed to provide further evidence supporting the role of tonsillectomy in the management of recurrent tonsillitis and obstructive sleep apnoea.MethodsA prospective uncontrolled observational study was undertaken examining 54 paediatric patients undergoing tonsillectomy at our institution. Parents of children having surgery were invited to complete a T-14 questionnaire preoperatively as well as at three and six months postoperatively.ResultsThe questionnaire was completed for 52 of the 54 patients preoperatively as well as at 3 and 6 months postoperatively (96% response rate). The mean difference between the preoperative and six-month T-14 score was 31.8 (p<0.0001). T-14 scores at three months were also significantly improved compared with those taken preoperatively (mean difference: 29.9, p<0.0001).ConclusionsThis is the first study in the literature to assess T-14 questionnaires at three and six months following paediatric tonsillectomy, providing evidence of the early benefit on PROMs. Tonsillectomy is the most common surgical procedure performed in the UK, and it is regarded highly by patients and otolaryngologists alike. This study provides significant evidence that tonsillectomy improves PROMs, thereby demonstrating its ongoing clinical value as a funded National Health Service procedure. 相似文献
403.
Predictive role of Selvester QRS score in patients undergoing transcatheter aortic valve replacement
Tiago Costa Bignoto MD PhD David Le Bihan MD PhD Rodrigo Bellio de Mattos Barretto MD PhD Auristela Isabel de Oliveira Ramos MD PhD Dalmo Antônio Ribeiro Moreira MD PhD Matheus Simonato MD Dimytri Alexandre de Alvim Siqueira MD PhD Ibraim Masciarelli Francisco Pinto MD PhD Tiago Senra Garcia dos Santos MD PhD Amanda Guerra de Moraes Rego Sousa MD PhD Alexandre Abizaid MD PhD 《Catheterization and cardiovascular interventions》2021,97(1):E95-E103
404.
Elucidating the prognostic significance of KRAS,NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer
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405.
Janaine Cunha Polese Aline Alvim Scianni Luci Fuscaldi Teixeira-Salmela 《Journal of Physical Therapy Science》2015,27(12):3739-3743
[Purpose] This study aimed to determine which clinical measures of walking performance
and lower limb muscle strength would predict energy cost during stair ascent and descent
in community-dwelling individuals with stroke. [Subjects and Methods] Regression analysis
of cross-sectional data from 55 individuals between one and five years post-stroke was
used to investigate the measures of walking (speed and distance covered during the
6-minute walk test [6MWT]), and strength of the paretic knee extensor and ankle plantar
flexor muscles would predict energy cost during stair ascent and descent. [Results] Three
predictors (habitual walking speed, distance covered during the 6MWT, and strength of the
paretic knee extensor muscles) were kept in the model. Habitual walking speed alone
explained 47% of the variance in energy cost during stair ascent and descent. When the
strength of the paretic knee extensor muscles was included in the model, the explained
variance increased to 53%. By adding the distance covered during the 6MWT, the variance
increased to 58%. [Conclusion] Habitual walking speed, distance covered during the 6MWT,
and strength of the paretic knee extensor muscles were significant predictors of energy
cost during stair ascent and descent in individuals with mild walking limitations.Key words: Stroke, Energy metabolism, Stairs 相似文献
406.
Alvim RO Santos PC Ferreira NE Mill JG Krieger JE Pereira AC 《Journal of human hypertension》2012,26(5):340-342
Thioredoxin interacting protein plays a pivotal role in several important processes of cardiovascular homeostasis by functioning as a biological sensor for biomechanical and oxidative stress. However, the effects of genetic variants in the modulation of arterial stiffness are unknown. In this scenario, the present study evaluated the relationship between the TXNIP rs7212 polymorphism and arterial stiffness. In the overall sample and in the diabetic group, individuals carrying CG+GG genotypes had higher PWV values compared with CC genotype group (10.0 vs 9.8?m?s (-1), P=0.03; 12.3 vs 11.2?m?s(-1), P=0.01; respectively). Our findings indicated that the G allele may contribute to increased arterial stiffness in the Brazilian general population and suggest a possible interaction with diabetes. 相似文献
407.
Deeg HJ; Aprile J; Storb R; Graham TC; Hackman R; Appelbaum FR; Schuening F 《Blood》1988,71(4):1138-1140
Untransfused dogs given 9.2 Gy total-body irradiation and hematopoietic grafts from DLA-identical littermate donors uniformly achieve sustained engraftment, whereas dogs given three transfusions (Tx) of whole blood from the intended marrow donor 24, 17 and 10 days pretransplant uniformly reject their graft. Sensitization appears to be mediated by peripheral blood mononuclear cells and can be prevented by prior irradiation of the Tx product with UV light, known to inactivate leukocytes, in particular, cells with accessory function. In the present study we investigated which leukocyte population was responsible for Tx-induced sensitization and subsequent marrow graft rejection. Surprisingly, neither monocytes nor macrophages or dendritic cells induced sensitization, and all dogs so treated achieved engraftment; however, all four evaluable dogs transfused with UV- exposed blood to which small numbers of normal dendritic cells (12.5 x 10(3)/kg) were added rejected their marrow graft. Among five dogs given UV-exposed blood and normal monocytes (12.5 x 10(3)/kg) only one rejected its graft, and four achieved sustained engraftment. We conclude that donor dendritic cells are necessary, albeit not sufficient for in vivo sensitization. Sensitization is prevented by elimination or inactivation of dendritic cell. 相似文献
408.
Alexandre Foga?a Cristante Paulo Alvim Borges Angelo Roberto Barbosa Olavo Biraghi Letaif Raphael Martus Marcon Tarcisio Eloy Pessoa de Barros-Filho 《Clinics (S?o Paulo, Brazil)》2014,69(10):672-676
OBJECTIVE:
To evaluate the association of clinical and demographic variables in patients requiring blood transfusion during elective surgery to treat scoliosis with the aim of identifying markers predictive of the need for blood transfusion.METHODS:
Based on the review of medical charts at a public university hospital, this retrospective study evaluated whether the following variables were associated with the need for red blood cell transfusion (measured by the number of packs used) during scoliosis surgery: scoliotic angle, extent of arthrodesis (number of fused levels), sex of the patient, surgery duration and type of scoliosis (neuromuscular, congenital or idiopathic).RESULTS:
Of the 94 patients evaluated in a 55-month period, none required a massive blood transfusion (most patients needed less than two red blood cell packs). The number of packs was not significantly associated with sex or type of scoliosis. The extent of arthrodesis (r = 0.103), surgery duration (r = 0.144) and scoliotic angle (r = 0.004) were weakly correlated with the need for blood transfusion. Linear regression analysis showed an association between the number of spine levels submitted to arthrodesis and the volume of blood used in transfusions (p = 0.001).CONCLUSION:
This study did not reveal any evidence of a significant association between the need for red blood cell transfusion and scoliotic angle, sex or surgery duration in scoliosis correction surgery. Submission of more spinal levels to arthrodesis was associated with the use of a greater number of blood packs. 相似文献409.
410.
Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis
TC Okoye PA Akah CO Okoli AC Ezike FN Mbaoji 《Asian Pacific journal of tropical medicine》2010,3(3):189-192
ObjectiveTo investigate the antimicrobial activity of the methanol leaf extract (ME), n-hexane fraction (HF), ethylacetate fraction (EF) and methanol fraction (MF), of Stachytarpheta cayennensis C. Rich (verbenaceae) as well as to ascertain the antispasmodic effects of the ME and the various fractions (HF, EF and MF) on acetylcholine (Ach) and histamine (H) induced contractions on isolated guinea pig ileum.MethodsThe in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella paratyphi, Candida albicans and Aspergillus niger.ResultsThe extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus niger. The minimum inhibitory concentration (MIC) of the extract and fractions (mg/mL) on Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella paratyphi respectively were ME 5.62, 14.12, 22.38, 2.11; EF 1.25, 6.30, 9.40, 9.40 and MF 3.98, 8.81, 39.80, 21.13. The n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus subtilis. The extract and fractions exhibited significant (P< 0.05) dose dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig ileum. Concentrations of the extract and fractions (μg/mL) which evoked 50% inhibition of maximal response exhibited by Ach were ME 0.64, HF 0.16, EF 0.08 and MF 0.15, while that of histamine included ME 5.12, HF 0.16, EF 0.04 and MF 0.64. Preliminary phytochemical studies on the extract and fractions indicated the presence of carbohydrates, alkaloids, saponins, flavonoids, steroids and terpenoids.ConclusionsThe extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine for wound healing and gastrointestinal ulceration. 相似文献