全文获取类型
收费全文 | 43673篇 |
免费 | 2757篇 |
国内免费 | 206篇 |
专业分类
耳鼻咽喉 | 583篇 |
儿科学 | 1557篇 |
妇产科学 | 1220篇 |
基础医学 | 4286篇 |
口腔科学 | 1803篇 |
临床医学 | 3890篇 |
内科学 | 9204篇 |
皮肤病学 | 833篇 |
神经病学 | 2736篇 |
特种医学 | 1562篇 |
外国民族医学 | 4篇 |
外科学 | 8213篇 |
综合类 | 889篇 |
现状与发展 | 3篇 |
一般理论 | 28篇 |
预防医学 | 2738篇 |
眼科学 | 1522篇 |
药学 | 3199篇 |
1篇 | |
中国医学 | 275篇 |
肿瘤学 | 2090篇 |
出版年
2024年 | 50篇 |
2023年 | 537篇 |
2022年 | 1115篇 |
2021年 | 1841篇 |
2020年 | 1145篇 |
2019年 | 1452篇 |
2018年 | 1968篇 |
2017年 | 1442篇 |
2016年 | 1635篇 |
2015年 | 1728篇 |
2014年 | 2098篇 |
2013年 | 2842篇 |
2012年 | 3450篇 |
2011年 | 3367篇 |
2010年 | 2112篇 |
2009年 | 1685篇 |
2008年 | 2378篇 |
2007年 | 2386篇 |
2006年 | 2237篇 |
2005年 | 1945篇 |
2004年 | 1709篇 |
2003年 | 1422篇 |
2002年 | 1261篇 |
2001年 | 485篇 |
2000年 | 412篇 |
1999年 | 401篇 |
1998年 | 323篇 |
1997年 | 230篇 |
1996年 | 261篇 |
1995年 | 184篇 |
1994年 | 186篇 |
1993年 | 155篇 |
1992年 | 202篇 |
1991年 | 217篇 |
1990年 | 170篇 |
1989年 | 149篇 |
1988年 | 137篇 |
1987年 | 111篇 |
1986年 | 111篇 |
1985年 | 137篇 |
1984年 | 104篇 |
1983年 | 73篇 |
1982年 | 78篇 |
1981年 | 80篇 |
1980年 | 63篇 |
1979年 | 67篇 |
1978年 | 48篇 |
1977年 | 43篇 |
1976年 | 44篇 |
1974年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
14.
International Urology and Nephrology - To report current results of complete penile disassembly technique in epispadias repair. In ten years, we have preformed 31 complete penile disassembly for... 相似文献
15.
Increased arterial stiffness in young normotensive patients with Turner syndrome: associations with vascular biomarkers 下载免费PDF全文
16.
To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic β-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured in high glucose (25 mM glucose) condition, with and without AE treatment. RIN-5F cells cultured in high glucose decreased cell viability and increased ROS levels after 48 hr compared with standard medium (5.5 mM glucose). Glucotoxicity was confirmed by significantly increased ROS production, increased pro-inflammatory (IFN-γ, IL-1β,) & decreased anti-inflammatory (IL-6&IL-10) cytokine levels, increased DNA fragmentation. In addition, we found increased Bax, caspase 3, Fadd, and Fas and significantly reduced Bcl-2 expression after 48 hr. RIN-5F treated with both high glucose and AE (20 μM) decreased ROS generation and prevent RIN-5F cell from glucotoxicity. In addition, AE treated cells cultured in high glucose were transferred to standard medium, normal responsiveness to glucose was restored within 8hr and normal basal insulin release within 24 hr was achieved when compared to high glucose. 相似文献
17.
Effects of Paclitaxel and Carboplatin Combination on Mechanical Myocardial and Microvascular Functions: A Transthoracic Doppler Echocardiography and Two‐Dimensional Strain Imaging Study 下载免费PDF全文
18.
19.
20.
Expression of TRIM22 mRNA in chronic hepatitis C patients treated with direct-acting antiviral drugs
Mariam Naveed Amjad Ali Nadeem Sheikh Shazia Rafique Muhammad Idrees 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2020,128(4):326-334
Hepatitis C is a global public health problem, and Pakistan is the second largest country in the globe with highest prevalence rate of hepatitis C virus (HCV). Until 2014, pegylated interferon (PEG-IFN) plus ribavirin (RBV) has been the standard therapy for HCV, however, owing to its adverse side effects and very low sustained virologic response (SVR) rates therapeutics trend is shifted toward direct-acting antivirals. Tripartite motif containing 22 (TRIM22) is a dynamic antiviral protein that can inhibit multiple viruses in vivo. Expression of TRIM22 mRNA has been linked to outcome of PEG-IFN and ribavirin therapy, where its higher expression leads to rapid virus clearance. However, in terms of therapy with direct-acting antiviral (DAA) or double DAA, impact of TRIM22 expression is largely unknown. These new drugs show more than 90% of SVR rates and lesser side effects and have proven to be better than IFN therapy. Endogenous IFN system suppresses various pathogens through the induction of antiviral effectors termed as interferon-stimulating genes (ISGs). We have studied the expression levels of one of these antiviral effectors, TRIM22 in response to sofosbuvir (SOF) and daclatasvir (DAC) in combination with RBV, using quantitative PCR in the peripheral blood mononuclear cells (PBMCs) of HCV-infected patients. We have observed sustained virus clearance in more than 90% of patients treated with DAA and double DAA and have seen the expression of TRIM22 to be higher in patients who attained SVR as compared to the untreated patients. We have also observed downregulation of TRIM22 in patients who failed to attain rapid virus clearance, and upregulation in those who achieved rapid clearance of virus. Genetic factors that determine the lower TRIM22 expression in these patients are needed to be explored that may also play a role in lower response to anti-HCV therapy. Endogenous IFN system and effects of antiviral proteins in response to DAA therapy is needed to be studied in order to better understand the host response toward these drugs to make them more effective. 相似文献