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111.
Ahn So-Hyeon Choi Nam-Kyong Kim Ye-Jee Seong Jong-Mi Shin Ju-Young Jung Sun-Young Park Byung-Joo 《Archives of pharmacal research》2015,38(6):1255-1262
Archives of Pharmacal Research - This study examined 1-year persistency with cholinesterase inhibitors (ChEIs) for the treatment of elderly Alzheimer’s dementia (AD) patients in Korea. Korean... 相似文献
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Aronow WS Ahn C Gutstein H 《The journals of gerontology. Series A, Biological sciences and medical sciences》2002,57(5):M333-M335
BACKGROUND: We report the incidence of new atherothrombotic brain infarction (ABI) in older men and women with prior myocardial infarction and a serum low-density lipoprotein (LDL) cholesterol of >or=125 mg/dl treated with statins and with no lipid-lowering drug. METHODS: The incidence of new ABI was investigated in an observational prospective study of 1410 men and women, mean age 81 +/- 9 years, with prior myocardial infarction and a serum LDL cholesterol of >or=125 mg/dl treated with statins (679 persons or 48%) and with no lipid-lowering drug (731 persons or 52%). Follow-up was 36 +/- 21 months. RESULTS: At follow-up, the stepwise Cox regression model showed that significant independent predictors of new ABI were age (risk ratio = 1.04 for a 1-year increase in age), cigarette smoking (risk ratio = 3.5), hypertension (risk ratio = 3.1), diabetes mellitus (risk ratio = 2.3), initial serum LDL cholesterol (risk ratio = 1.01 for each 1 mg/dl increase), initial serum high-density lipoprotein cholesterol (risk ratio = 0.97 for each 1 mg/dl increase), prior stroke (risk ratio = 2.5), and use of statins (risk ratio = 0.40). The Cochran-Armitage test showed a trend in the reduction of new ABI in persons treated with statins as the level of serum LDL cholesterol decreased ( p <.0001). CONCLUSIONS: Use of statins caused a 60%, significant, independent reduction in new ABI in older men and women with prior myocardial infarction and a serum LDL cholesterol of >or=125 mg/dl. 相似文献
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J.K. Ahn J. Hwang J.H. Hwang W.T. Yoon P.W. Chung S. Ryu 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2018,28(1):14-22
Background and aims
Intracranial arterial stenosis (ICAS) is one of the most common causes of stroke, especially in Asians. Hyperuricemia has been associated with an increased risk of comorbidities such as metabolic syndrome or cardiovascular diseases. However, there are few studies focusing on the association between serum uric acid (SUA) levels and asymptomatic ICAS. The aim of this study was to explore the association between SUA and the prevalence of ICAS in middle-aged Korean health screening examinees.Methods and results
A cross-sectional study was performed on 9417 males and 7755 females who underwent a comprehensive health examination including transcranial Doppler (TCD) ultrasonography. The association of SUA and ICAS was analyzed using multivariate logistic regression. The prevalence of ICAS among the total examinee population was 3.55%. In females, the multivariate-adjusted odds ratio for ICAS was 1.52 (confidence interval 1.13–2.04) in the 3rd quartile of SUA and 1.45 (1.05–2.00) in the highest quartile, compared to the reference (P for trend 0.008). This trend was evident in all clinically relevant subgroups evaluated, including women with low inflammation status. SUA was not significantly associated with the prevalence of ICAS among males. In a sensitivity analysis, the multivariate-adjusted odds ratio of middle cerebral artery stenosis in females was 1.60 (1.09–2.37) in the highest quartile compared to the reference (P for trend 0.023).Conclusions
Higher SUA level was associated with increased risk of ICAS among middle-aged females but not males. A further cohort study is warranted to elucidate the effect of SUA on asymptomatic ICAS. 相似文献119.
We used a dual-chamber culture system separated by a dialysis membrane to test the efficiency of expansion of whole cord blood and cell fractions. We found that expansion of progenitor cells was more efficient from whole blood than from purified CD34+ or partially purified mononuclear cell fractions. 相似文献
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Calvo-Vargas CG Herrera C Parra-Carrillo J Ahn C Arellano-Chaides A 《Blood pressure monitoring》1996,1(6):463-467
OBJECTIVE: To compare 24 h blood pressure changes in medical residents when on call with those of a normal workday. DESIGN: Ambulatory blood pressure was recorded in 30 normotensive residents (14 men and 16 women) aged 27+/-2 years, during on-call workdays (24 h in the hospital) and then compared with values obtained during a normal 8 h workday. Ambulatory blood pressure was recorded every 15 min during the day (0700-2200 h) and every 20 min during the night (2200-0700 h). RESULTS: The normal workday 24 h ambulatory mean blood pressure rose from 85.0 mmHg to the on-call mean blood pressure of 88.9 mmHg (P < 0.001). During the daytime, ambulatory systolic and diastolic blood pressures rose by 4.6 mmHg (P < 0.001) and 2.7 mmHg (P < 0.001), respectively. During the night-time period, systolic and diastolic blood pressures rose by 5.4 mmHg (P < 0.01) and 4.6 mmHg (P < 0.01), respectively. The nocturnal systolic and diastolic blood pressure elevation was not related to gender, body mass index, waist: hip ratio, physical exercise or smoking habits. CONCLUSION: The on-call workday causes an elevation in mean 24 h blood pressure and only minimal changes in the 24 h blood pressure pattern. 相似文献