孕早期鸢尾素水平与孕妇糖脂代谢和妊娠期糖尿病风险的分析

目的:分析孕早期鸢尾素水平与孕妇糖脂代谢及患妊娠期糖尿病风险的相关性.方法:将2018年1月～2019年12月邢台市第三医院行常规产前检查的253例孕妇纳入研究,所有孕妇均于孕早期检测体内血糖、血脂及鸢尾素等实验室指标水平,并根据孕24～28周葡萄糖耐量试验结果将孕妇分为妊娠期糖尿病(GDM)组及无GDM组,比较两组患...     

正常角膜与圆锥角膜粘弹性的对比研究

研究在体角膜材料的力学特性,是进一步借助有限元方法研究角膜生理与病理现象的重要基础。本文借助可视化角膜生物力学分析仪所提供的数据,使用标准线性固体模型计算正常角膜和圆锥角膜在脉冲气压作用下的弹性系数(E)和粘性系数(η)。研究发现,正常角膜和圆锥角膜的E与η之间的差异具有统计学意义(P 0.05)。受试者工作特征曲线分析发现,E、η及其联合指标的曲线下面积(AUC)分别为0.776、0.895、0.948,说明该指标可以对圆锥角膜进行较好的预测。本文研究结果或可为圆锥角膜的早期诊断提供参考,以避免术后圆锥角膜的发生,因此具有一定的临床实用价值。     

自身免疫性甲状腺损害与甲状腺功能减退症

自身免疫性甲状腺损害与甲状腺功能减退症高妍甲状腺功能减退症（甲减）是较常见的内分泌疾病，由各种原因引起甲状腺激素分泌不足，血中甲状腺激素水平减低或靶器官对其拮抗而引起。绝大多数是因甲状腺本身损害所致原发性甲减，少数是由垂体或下丘脑疾病引起的继发性甲减...     

B.BRAUN Omnitest(○R)电子感应血糖仪临床验证报告

糖尿病代谢控制的重要内容为血糖监测,由于其直接关系到糖尿病的治疗,因此测血糖方法的准确性和便利程度一直是临床医生十分关注的问题.本文对B.BRAUN OmnitestR电子感应血糖仪的精确性进行了评估,探讨其精确性和准确性.     

氨茶碱致心律失常36例分析

氨茶碱因其显著扩张支气管、增加心肌收缩力及利尿作用而广泛地在临床使用，用于治疗气管炎、支气管炎、哮喘、心力衰竭等，取得良好临床治疗效果和临床经济效益。     

丙基硫氧嘧啶对甲状腺功能亢进症患者血清甲状腺激素水平的影响

本文报告29例甲亢患者一次顿服PTU 200mg后血清甲状腺激素水平的急性变化,及15例患者日服PTU 300mg连续4周后血清甲状腺激素水平的慢性变化。并以Methimazole为对照进行比较,探讨了PTU急性和慢性作用的机理及临床实用意义。本研究结果表明,PTU可能通过对5＇脱碘酶的抑制,减少外周组织T_4转换成T_3,迅速控制血清中生物活性较强的T_3水平,在严重甲亢或甲亢危象时应首先选用。PTU及Methimazole长期应用均可使血清甲状腺激素水平显著下降,且两药效果无明显差别。     

甲状腺机能亢进性心脏病

甲状腺机能亢进(下称甲亢)时心脏的改变比较明显。由于甲状腺激素直接作用于心肌,可增加心肌组织中Na~+—K~+—ATP酶及肌球蛋白ATP酶活性,兴奋心肌腺苷环化酶,降低心脏对迷走神经刺激的敏感性,增加肾上腺素能交感活动,故可使心串加快,心肌收缩力加强,心搏出量增加,心脏指数常达5～7 L/(min·m~2),外周血管阻力下降。为适应上述代谢的需要,增加周围组织供氧,临床     

中国门诊2型糖尿病患者口服药降糖达标状况调查及格列齐特缓释片优化治疗效果分析

Objective To evaluate the current state of glycemie control in Chinese patients with type 2 diabetes mellitus who have received oral antidiabetic agents in the out-patient clinic,and the efficacy and safety of optimized regiments of gliclazide modified-release tablets (Diamicron MR, SERVIER, Tianjin) in patients with failed glycemic control (HbA1c 6.5%). Methods The patients with type 2 diabetes were enrolled from 54 hospitals in more than 20 cities and received long-term (more than 3 months) oral antidiabetic agents. HbA1c was measured and the success rate of HbA1c reduction was evaluated. The patients who failed to achieve glycemic control (HbA1c 6. 5%) and received daily multiple-dosing insulin secretagogues were provided with the optimized treatment regimen, consisting of replacing daily multiple-dosing insulin secretagogues with single-dosing gliclazide sustained-release tablets. Clinical efficacy and safety were evaluated after three months treatment. Results The survey of glycemic control revealed that the mean HbA1c of 5 586 patients with diabetes mellitus was (7.97±2.89)% ,and the success rate (HbA1c≤6.5%) was 14. 1%. Further more, HbA1c decreased from (8.23±4.00)% before optimization to (6.86±2.24)% after optimization with the average decrement of 1.37% (P<0. 001) and the success rate was raised to 34. 1%. The gliclazide modified-release tablets were well tolerated by most patients, only 2.6% of whom were reported to experience unconfirmed hypoglycemia. Conclusion The success rate of glycemic control was low in Chinese out-patients with type 2 diabetes mellitus receiving oral antidiabetic agents in the clinic. The optimized regimen of gliclazide modified-release tablets taken once daily can down-regulate glycemic levels and increase the success rate of HbA1c reduction,and thus plays efficiently and safely a key role in the optimized management of type 2 diabetes mellitus.     

冬虫夏草繁育品质量控制和药理活性研究进展

冬虫夏草为传统的名贵中药材,在中国有悠久的药用历史,具有补肾、益肺、止血、化痰的功效。近年来,冬虫夏草繁育品的研究获得突破,实现了冬虫夏草的大规模产业化繁育。冬虫夏草繁育品基原符合中国药典规定,与野生冬虫夏草相比,冬虫夏草繁育品不仅具有相似的化学成分和药理活性,还具有较低的重金属含量,安全性更容易控制。