BREAST CONSERVING THERAPY IN STAGE T1 ＆ T2 BREAST CANCER PATIENTS

Objective: To investigate the effect of breast-conservation therapy in early stage breast cancer. Methods: A total of 234 early stage breast carcinoma patients received breast conserving treatment in our hospital. After the operation, they underwent adjuvant chemotherapy and radiotherapy. All of these patients desired to preserve their breasts. Results: After median follow-up of 29.46 months (range from 3 to 100 months), 3 cases had local relapse and 8 cases had distant metastasis. The overall survival rate of 5 year was 96.7%, and the disease free survival rate of 5 year was 87.85%. Conclusion: For early stage breast carcinoma patients, classic quadrantectomy, axillary dissection and post-operative adjuvant chemotherapy and radiotherapy lead to excellent local control and good survival.     

乳房切除术后即时乳房重建和放疗的临床结果

乳腺癌患者乳房切除手术后对患者心理和生理有着不利的影响,因此乳房重建手术越来越受到重视.放疗能够降低局部区域复发,但术后放疗对重建乳房美容效果的影响及技术实施上的难点成为近年来引起关注的特殊临床问题[1].笔者回顾28例乳腺癌患者乳房切除术加即时乳房重建及放疗后的近期结果 ,分析即时乳房重建后放疗的可行性.     

乳腺癌表达细胞周期蛋白依赖性激酶抑制物p27kip1的预后意义

研究ｐ２７＾ｋｉｐｌ在乳腺癌组织中的表达水平,及其与生物学行为的关系和对预后的作用。方法以免疫组化法检测１８１例乳腺癌组织ｐ２７＾ｋｉｐｌ蛋白表达水平,其中９１例进行了凋亡指数、凋亡相关蛋白ｂｃｌ－２、ｂａｘ的测定,另有１０６例检测了ｐ２１＾ＷＡＦ１／ＣＩＰＩ、ｐ５３、ｍｄｍ２蛋白表达水平。结果本组１８１例中,ｐ２７＾ｋｉｐｌ蛋白阳性１２５例,占６９．１％;低表达者１２１例,占６６．９％;高表达者     

趋化因子与肿瘤免疫

趋化因子是细胞因子超家族成员中一大类可特异性激活和募集白细胞的小分子蛋白多肽 ,其氨基酸组成具有特异的半胱氨酸 (Cys)基序[1] 。根据特征性保守Cys基序的组成排列差异分为CXC、CC、C、CX3 C四类趋化因子。CXC类趋化因子又按有无ELR基序 (Glu Leu Arg)分为ELR CXC趋化因子和non ELR CXC趋化因子。趋化因子受体属G蛋白偶联的 7次跨膜型受体超家族 ,目前已经得以鉴定的达 19种[2 ] ,根据其特异性结合的相应配体而命名。包括 6种CXC趋化因子受体 (CXCR1CXCR6 )、11种CC趋化因子受体 (CCR1CCR11)、一种C趋化因子受体…     

整合素α5亚基蛋白的表达与乳腺癌病理和临床的关系

整合素是与肿瘤转移密切相关的细胞粘附分子之一。近年来发现,它参与肿瘤细胞转移粘附过程。我们应用免疫组织化学方法检测了乳腺癌中整合素α５亚基的表达情况,探讨其与乳腺癌病理和临床生物指标的关系。一、对象和方法１对象：上海医科大学肿瘤医院１９８８～１９８...     

乳腺癌细胞凋亡及相关基因表达的预后研究

目的 对细胞凋亡及其相关基因在乳腺癌预后中的作用,以及它们的表达水平与乳腺癌生物学行为的关系进行研究。方法 运用ＴＵＮＥＬ法、免疫组化检测乳腺癌组织细胞凋亡水平以及凋亡相关基因ｂｃｌ－２、ｂａｘ、ｐ２７＾ｋｉｐｌ表达。结果 ９１例乳腺癌病例中,５６／９１（６１．５％）的病例凋亡指数较高,３５／９１（３８．５％）凋亡指数较低;ｂｃｌ－２高表达占２９．７％（２７／９１）,ｂａｘ高表达占３０．８％（２８     

EXPRESSION OF THE RETINOIC ACID RECEPTORS(RARs)AND RETINOID X RECEPTOR(RXRs)GENES IN BREAST CANCER

A number of studies have been shown that retiniodscan inhibit malignant cell growth including certain breastcarcinoma cells. its inhibitory effort is observed only inER-positive but not in ER-negative breast cancer cells.We examined retinoic acid receptors (RARs) andretinoids X receptors(RXRs) levels in 6 breast carcinomacell lines and 18 breast cancer biopsy specimens. Wefound that RAR-α mRNA level was significantly higher inER Positive cell lines and samples. RAR-γ mRNA wasexpressed at relatively high levels in majority of tumorsamples independent of the ER-status while RAR-βmRNA was expressed at low levels. We also found highRXR-α mRNA levels in all of the tumor samplesexamined while RXR-γ mRNA could not be detected.Our study suggests a possibility that retinoids inhibittumor cell growth through RAR-α and RAR-α levels mayserve as a potential marker to determine responsivenessof patients to retinoids therapy.     

女性乳腺癌二级预防策略简介

复习妇女乳腺 高危因素的研究以及预防措施评价的文献，探讨女性乳腺癌的二级预防策略。     

家族性乳腺癌

家族史对乳腺癌的危险性有复杂影响。遗传性乳腺癌占首次确诊病人的5%—10%,而30岁以下者占1/4。另有10%的乳腺癌病人具有明显的家族聚集性,但未找到明确的遗传因子。本文就家族性乳腺癌的高危因素、普查及化学预防作一综述。     

外周血HER2基因扩增检测(数字PCR法)在抗HER2治疗中的应用共识

乳腺癌患者中20％～30％人表皮生长因子受体2(human epidermal growth factor receptor 2, HER2)阳性,该类型乳腺癌具有恶性程度高、侵袭性强、预后差等特点.抗HER2靶向药物能有效地降低HER2阳性乳腺癌患者复发和转移的风险,延长生存期,改善预后[1],HER2状态是乳腺癌重...