全文获取类型
收费全文 | 239519篇 |
免费 | 8394篇 |
国内免费 | 4045篇 |
专业分类
耳鼻咽喉 | 3044篇 |
儿科学 | 7803篇 |
妇产科学 | 6307篇 |
基础医学 | 30438篇 |
口腔科学 | 6457篇 |
临床医学 | 21867篇 |
内科学 | 41718篇 |
皮肤病学 | 5050篇 |
神经病学 | 13977篇 |
特种医学 | 12476篇 |
外国民族医学 | 120篇 |
外科学 | 33151篇 |
综合类 | 8838篇 |
现状与发展 | 15篇 |
一般理论 | 8篇 |
预防医学 | 19036篇 |
眼科学 | 5717篇 |
药学 | 18382篇 |
83篇 | |
中国医学 | 2997篇 |
肿瘤学 | 14474篇 |
出版年
2022年 | 1819篇 |
2021年 | 2694篇 |
2020年 | 2094篇 |
2019年 | 1700篇 |
2018年 | 5203篇 |
2017年 | 5335篇 |
2016年 | 4555篇 |
2015年 | 6945篇 |
2014年 | 6833篇 |
2013年 | 5615篇 |
2012年 | 13085篇 |
2011年 | 8397篇 |
2010年 | 4441篇 |
2009年 | 5615篇 |
2008年 | 4373篇 |
2007年 | 5157篇 |
2006年 | 5351篇 |
2005年 | 13559篇 |
2004年 | 13968篇 |
2003年 | 9416篇 |
2002年 | 4436篇 |
2001年 | 5407篇 |
2000年 | 2815篇 |
1999年 | 7016篇 |
1998年 | 1286篇 |
1992年 | 7232篇 |
1991年 | 7397篇 |
1990年 | 7619篇 |
1989年 | 7178篇 |
1988年 | 6693篇 |
1987年 | 6430篇 |
1986年 | 6097篇 |
1985年 | 5345篇 |
1984年 | 3635篇 |
1983年 | 2946篇 |
1979年 | 3839篇 |
1978年 | 2361篇 |
1977年 | 1781篇 |
1976年 | 1559篇 |
1975年 | 2473篇 |
1974年 | 3105篇 |
1973年 | 2738篇 |
1972年 | 2756篇 |
1971年 | 2742篇 |
1970年 | 2555篇 |
1969年 | 2464篇 |
1968年 | 2237篇 |
1967年 | 2163篇 |
1966年 | 1899篇 |
1965年 | 1131篇 |
排序方式: 共有10000条查询结果,搜索用时 890 毫秒
11.
12.
目的评估血肌酐和尿常规的常规检测基础上联合血清胱抑素C和尿微量白蛋白检测在人类免疫缺陷病毒(HIV)感染者肾功能损伤检测中的应用价值。
方法以2019年2~5月于首都医科大学附属北京地坛医院感染一科住院的169例HIV感染者为研究对象,完善其尿常规、尿微量白蛋白、血肌酐、血清胱抑素C检测;分析尿蛋白及尿微量白蛋白的阳性检出率及其差异,血肌酐升高及血清胱抑素C升高的比例及其差异。计算应用替诺福韦酯(TDF)及合并丙型肝炎、高血压、糖尿病、肿瘤的肾功能损伤的相对危险度。
结果169例HIV感染者中尿常规示尿蛋白阳性者5例(3.0%),尿微量白蛋白升高者17例(10.1%),两者阳性检出率差异具有统计学意义(χ2 = 5.9、P = 0.007)。血肌酐升高者10例(5.9%),血清胱抑素C升高者20例(11.8%),两者阳性检出率差异具有统计学意义(χ2 = 3.0、P = 0.042)。在尿常规和血肌酐检测的基础上联合检测尿微量白蛋白和血清胱抑素C的总体阳性检出率为49例(30.0%)。CD4+ T淋巴细胞计数< 200个/μl与≥ 200个/μl组患者血清胱抑素C水平分别为0.94(0.83,1.05)mg/L、0.85(0.77,0.95)mg/L,差异具有统计学意义(Z =-3.02、P = 0.003)。应用TDF及合并丙型肝炎、高血压、糖尿病、肿瘤的肾功能损伤的相对危险度分别为1.1、1.5、1.9、2.2和1.4。
结论HIV感染者中,单纯以尿常规为依据评估有无蛋白尿,以血肌酐水平为依据评估肾小球滤过功能会低估肾功能损伤的患病率。在常规检测血肌酐和尿常规的基础上联合检测血清胱抑素C和尿微量白蛋白在提高HIV感染者肾功能损伤检出率方面具有重要的应用价值。低CD4+ T淋巴细胞计数、应用TDF及合并丙型肝炎、高血压、糖尿病、肿瘤均为肾功能损伤的危险因素。 相似文献
14.
15.
16.
17.
18.
Attachment is a behavioral and physiological system, which enables individual’s dynamic adaptation to its environment. Attachment develops in close interaction between an infant and his/her mother, plays an important role in the development of the infant’s brain, and influences the quality of interpersonal relationships throughout life.Security of attachment is believed to influence individual response to stress, exposing insecurely organized individuals to deregulated autonomic nervous system and exaggerated hypothalamic-pituitary-adrenal activity, which, in turn, produces increased and prolonged exposure to stress-hormones. Such stress responses may have considerable implications for the development of diverse health-risk conditions, such as insulin resistance and hyperlipidemia, shown by numerous studies.Although the mechanisms are not yet fully understood, there is compelling evidence highlighting the role of psychological stress in the development of type 1 diabetes (T1D). One of the possible contributing factors for the development of T1D may be the influence of attachment security on individual stress reactivity. Thus, the suggestion is that insecurely attached individuals are more prone to experience increased and prolonged influence of stress hormones and other mechanisms causing pancreatic beta-cell destruction.The present paper opens with a short overview of the field of attachment in children, the principal attachment classifications and their historic development, describes the influence of attachment security on individual stress-reactivity and the role of the latter in the development of T1D. Following is a review of recent literature on the attachment in patients with T1D with a conclusion of a proposed role of attachment organization in the etiology of T1D. 相似文献
19.
Torbj?rn Karlsson 《Upsala journal of medical sciences》2015,120(4):257-262
Background. Haemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterized by fever, hepatosplenomegaly, cytopenia, and progressive multiple-organ failure. HLH in adults is often secondary to autoimmune diseases, cancer, or infections in contrast to familial HLH. Treatment of secondary HLH is directed against the triggering disease in addition to immunosuppressive therapy, the latter commonly according to the HLH-2004 protocol.Methods. We conducted a retrospective study to identify triggering diseases, disease-specific and immunosuppressive therapy administered, and prognosis in adult patients with secondary HLH. Patient data were collected from October 2010 to January 2015.Results. Ten adult patients with secondary HLH were identified. Seven were men, and the median age at diagnosis was 62 years. Five cases were triggered by malignant disease and five by infection. The median patient fulfilled five of the eight HLH-2004 diagnostic criteria. All patients fulfilled the criteria fever, cytopenia, and ferritin >500 µg/L. Median time from hospital admission to HLH diagnosis was 20 days. Four patients received immunosuppressive therapy according to the HLH-2004 protocol. The prognosis was dismal, especially for the patients with malignancy-associated HLH, of whom all died.Conclusion. HLH should be suspected in patients who present with fever, cytopenia, and ferritin >500 µg/L. Secondary HLH has a dismal prognosis. None of the patients with HLH triggered by malignancy survived. Achieving remission of the triggering disease seems to be important for a favourable outcome as, in all surviving patients, the haemophagocytic syndrome resolved after remission of the underlying infection. 相似文献
20.