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31.
淋巴管作为循环系统的重要组成部分之一,具有调节机体体液稳态,协助免疫监视和肠道脂质吸收等重要作用。淋巴管新生是机体生理和病理过程中维持脉管系统结构和功能正常的重要手段,淋巴管新生调控对于防治肿瘤、心血管等诸多疾病有着潜在的临床转化意义;淋巴回流功能则与关节炎症等疾病发病机制关系密切。在循环系统中,相较于中医药调控血管相关疾病的发病机制已取得很大进展,近年来对于淋巴管的研究则明显相对滞后。本文从中医药作用于淋巴管新生及回流功能角度对这一领域的研究进展作一综述,以期为临床上中医药治疗相关疾病提供新的思路与方法。 相似文献
32.
目的 利用筛选出十堰的天师栗中高多态性SSR位点评价天师栗种质资源的遗传多样性,结合有效药用成分含量,构建十堰地区天师栗核心种质库。方法 收集十堰地区114份天师栗种质资源,以七叶树基因组为参考,采用荧光毛细管电泳筛选出高多态性SSR位点,对天师栗种质资源进行遗传多样性分析。利用HPLC测定不同种质干燥娑罗子中七叶皂苷的含量。采用最小距离逐步聚类取样策略(LDSS),根据遗传多样性保留程度初步筛选出核心种质,并对该核心种质与原始种质的遗传多样性参数进行T检验,选择与原种质差异不显著的核心种质为最佳核心种质。结果 筛选出13对高多态性SSR分子标记,遗传多样性评价结果表明十堰地区天师栗种质资源遗传多样性较高,遗传分化较小,存在着较大的基因流,114份种质资源未分为不同的亚群,周家坝和辽叶居群间具有较近的遗传亲缘关系,且周家坝居群娑罗子中的七叶皂苷A及七叶皂苷B含量普遍较高。最终筛选出的核心种质共23份,占总种质资源的20.17%,其中周家坝12份样本、辽叶6份样本、普龄5份样本。结论 将SSR分子标记与主要有效药用成分结合,采用LDSS取样策略构建十堰地区天师栗种质资源核心种质库的方法具有可行性,能够有效的保存与管理天师栗种质资源,也为当地天师栗品种改良、新品种选育研究等提供了研究基础。 相似文献
33.
Wei Zhang Zheng Li Feng-Qing Xu Ya-Shuo Ren Shuang-Wang Xu Tong-Sheng Wang 《Journal of Asian natural products research》2019,21(5):426-434
Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP+) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.
34.
目的 检测微小核糖核酸(microribonucleicacids,miRNA)在老年性黄斑变性(age-related macular degeneration,AMD)患者中的表达,并探讨miRNA的表达量与AMD病程之间的关系。方法 选取2014年1月至2016年11月于同济大学附属第十人民医院眼科门诊就诊的AMD患者6例为试验组,并选取同期6名正常人为对照组,通过基因芯片技术检测两组血液中miRNA的表达量。扩大样本的病例对照研究中共纳入126例AMD患者和140名正常人,检测其血液样本中miRNA的表达,比较两组人群间miRNA的表达量差异。结果 通过基因芯片技术,在试验组与对照组间共检测出216个miRNA存在表达差异(均为P<0.05),与对照组相比,试验组中111个miRNA表达量上升,105个miRNA表达量下降,差异均有统计学意义(均为P<0.05)。扩大样本的病例对照研究结果表明,在AMD患者中,miR-27a-3p、miR-29b-3p、miR-195-5p的表达量显著上升,同时,湿性AMD患者血液中miR-27a-3p的表达量高于干性AMD患者,差异均有统计学意义(均为P<0.05)。结论 AMD患者外周血中miRNA表达量水平有明显变化,miR-27a-3p、miR-29b-3p、miR-195-5p可能成为AMD血清学诊断和预后的标志物。 相似文献
35.
36.
Victoria A. Chang Dawn M. Meyer Brett C. Meyer 《Journal of stroke and cerebrovascular diseases》2019,28(1):163-166
Background
Acute stroke codes may be activated for anisocoria, but how often these codes lead to a final stroke diagnosis or alteplase treatment is unknown. The purpose of this study was to assess the frequency of anisocoria in stroke codes that ultimately resulted in alteplase administration.Methods
We retrospectively assessed consecutive alteplase-treated patients from a prospectively-collected stroke registry between February 2015 and July 2018. Based on the stroke code exam, patients were categorized as having isolated anisocoria [A+(only)], anisocoria with other findings [A+(other)], or no anisocoria [A?]. Baseline demographics, stroke severity, alteplase time metrics, and outcomes were also collected.Results
Ninety-six patients received alteplase during the study period. Of the 94 who met inclusion criteria, there were 0 cases of A+(only). There were 9 cases of A+(other) (9.6%). A+(other) exhibited higher baseline National Institutes of Health (NIH) Stroke Scale scores compared to A? (17 versus 7; P?=?.0003), and no additional differences in demographics or alteplase time metrics. Final stroke diagnosis and other outcome measures were no different between A+(other) and A?. Of the A+ patients without pre-existing anisocoria, 5 of 6 (83%) had posterior circulation events or diffuse subarachnoid hemorrhage.Conclusions
In this exploratory analysis, zero patients with isolated anisocoria received alteplase treatment. Anisocoria as a part of the neurologic presentation occurred in 10% of alteplase patients, and was strongly associated with a posterior circulation event. Therefore, we conclude that anisocoria has a higher likelihood of leading to alteplase treatment when identified in the presence of other neurologic deficits. 相似文献37.
Chien-Hua Tseng Ben-Jei Tsuang Chun-Ju Chiang Kai-Chen Ku Jeng-Sen Tseng Tsung-Ying Yang Kuo-Hsuan Hsu Kun-Chieh Chen Sung-Liang Yu Wen-Chung Lee Tsang-Wu Liu Chang-Chuan Chan Gee-Chen Chang 《Journal of thoracic oncology》2019,14(5):784-792
Introduction
For never-smokers (smoked <100 lifetime cigarettes), lung cancer (LC) has emerged as an important issue. We aimed to investigate the effects of prevalence changes in tobacco smoking and particulate matter (PM) 2.5 (PM2.5) levels on LC in Taiwan, in relation to contrasting PM2.5 levels, between Northern Taiwan (NT) and Southern Taiwan (ST).Methods
We reviewed 371,084 patients with LC to assess smoking prevalence and correlations between the incidence of adenocarcinoma lung cancer (AdLC) and non-AdLC. Two subsets were selected to assess different AdLC stage trends and the effect of PM2.5 on survival of patients with AdLC.Results
From 1995 to 2015, the proportion of male adult ever-smokers decreased from 59.4% to 29.9% whereas the female smoking rate remained low (3.2% to 5.3%). AdLC incidence in males and females increased from 9.06 to 23.25 and 7.05 to 24.22 per 100,000 population, respectively. Since 1993, atmospheric visibility in NT improved (from 7.6 to 11.5 km), but deteriorated in ST (from 16.3 to 4.2 km). The annual percent change in AdLC stages IB to IV was 0.3% since 2009 (95% confidence interval [CI]: -1.9%–2.6%) in NT, and 4.6% since 2007 (95% CI: 3.3%–5.8%) in ST; 53% patients with LC had never smoked. Five-year survival rates for never-smokers, those with EGFR wild-type genes, and female patients with AdLC were 12.6% in NT and 4.5% in ST (hazard ratio: 0.79, 95% CI: 0.70–0.90).Conclusions
In Taiwan, greater than 50% of patients with LC had never smoked. PM2.5 level changes can affect AdLC incidence and patient survival. 相似文献38.
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2019年12月始,新型冠状病毒肺炎(Corona Virus Disease 2019,COVID-19)以湖北武汉为中心向全国各地蔓延。目前数据显示,COVID-19合并糖尿病、高血压、肿瘤等基础病的患者病情较为严峻,病死率相对较高。该类患者的临床治疗策略有待进一步深入研究。在此次疫情防治过程中,中西医结合治疗手段于COVID-19的防治及患者基础疾病的兼顾治疗方面展现出了一定的特色及优势。本文结合中医“未病先防,既病防变,瘥后防复”思想,拟从COVID-19合并糖尿病、高血压、肿瘤三个方面,探讨COVID-19爆发形势下合并基础病患者的中医药防治策略。 相似文献