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Gaujoux S Maggiori L Bretagnol F Ferron M Panis Y 《Journal of gastrointestinal surgery》2012,16(3):629-634
Background
Feasibility of single port access (SPA) colorectal surgery has been established for various procedures from ileocecal resection to proctectomy. Nevertheless, its benefits compared to conventional laparoscopy still need to be assess. The aim of this study was to compare SPA to conventional colorectal laparoscopic surgery in a single institutional case-matched study. 相似文献992.
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Ménézo Yves Patrizio Pasquale Alvarez Silvia Amar Edouard Brack Michel Brami Charles Chouteau Jacques Clement Arthur Clement Patrice Cohen Marc Cornet Dominique Dale Brian D’ Amato Guiseppe Jacquesson-Fournols Laetitia Mares Pierre Neveux Paul Sage Jean Clement Servy Edouard Huong To Minh Viot Geraldine 《Journal of assisted reproduction and genetics》2021,38(9):2383-2389
Journal of Assisted Reproduction and Genetics - MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-nucleotide polymorphisms that significantly reduce its activity,... 相似文献
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Sourdet S Van Kan GA Soto ME Houles M Cantet C Nourhashemi F Vellas B Pahor M Rolland Y 《Journal of the American Medical Directors Association》2012,13(4):407.e1-407.e6
ObjectivesThe aim of this study was to explore the predictive value of an abnormal one-leg balance (OLB) test for functional decline, nursing home admission, and mortality in community-dwelling patients affected with Alzheimer’s disease (AD).DesignA 2-year prospective, observational cohort study.SettingNineteen memory centers across France.ParticipantsA total of 686 community-dwelling patients with AD.MeasurementsMini-mental state examination, Activity of Daily Living scale, and balance (ability to stand unassisted for 5 seconds on 1 leg) were reported every 6 months. Functional decline was defined as a loss of 0.5 or more points at a 5-point Activity of Daily Living score (bathing, dressing, toileting, continence, and feeding). Nursing home admission and mortality were recorded. Neuropsychiatric symptoms, medication, and caregiver’s burden were assessed every 6 months. Time-to-event analyses were used.ResultsAt baseline, 632 patients with AD had a balance measurement (mean age = 77.8 years, SD = 6.9; 72.2% were women) and 15.2% had an abnormal OLB test: these patients were older, had lower mini-mental state examination and Activity of Daily Living scores, and more neuropsychiatric symptoms, osteoarthritis, comorbidities and medications (all P < .05). After adjustment for age and sex, the risk of functional decline (hazard ratio [HR]: 1.69; 95% confidence interval [CI], 1.26–2.26), nursing home admission (HR: 2.51; 95% CI, 1.69–3.73), and death (HR: 2.42; 95% CI, 1.43–4.11) was higher in patients with an abnormal OLB. After adjustment for other potential confounders, the presence of an abnormal OLB was significantly associated only with nursing home admission (HR: 1.73, 95% CI, 1.09–2.75).ConclusionIn the present study, an abnormal OLB predicts nursing home admission in patients with AD. Although statistically significant when solely adjusted for age and sex, an abnormal OLB test failed to predict functional decline and mortality when adjusted for multiple confounders. 相似文献
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