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991.
Shoichiro Sumi MD Dr. Kazutomo Inoue MD Masafumi Kogire MD Ryuichiro Doi MD Mitsutoshi Yun MD Hiromu Kaji MD Ryo Hosotani MD Masaki Fujimura MD Kotaro Uchida MD Shinya Kiyama PhD Kouki Kitagawa PhD Haruaki Yajima PhD Nobutaka Fujii PhD Takayoshi Tobe MD 《Digestive diseases and sciences》1991,36(11):1523-1528
This study examined the effect of synthetic porcine neuropeptide Y on the splanchnic blood flows and the exocrine pancreatic secretion in dogs. Graded doses of neuropeptide Y (0.1–5 g/kg, intravenous) caused dose-dependent reduction of the secretin-stimulated exocrine pancreatic secretion and of the blood flows in the superior mesenteric artery, the portal vein, and the pancreatic tissue. Neuropeptide Y at 5 g/kg reduced the blood flows to 45.9±13.3% (superior mesenteric artery), 63.0±10.5% (portal vein), and 77.9±4.8% (pancreatic tissue), respectively. This dose also reduced secretin-stimulated pancreatic juice volume and CCK-8 plus secretin-stimulated protein output to 65.2±9.3 and 63.3±14.0%, respectively. This study shows a potent vasoconstrictor effect of neuropeptide Y on splanchnic vessels. Neuropeptide Y also inhibited exocrine pancreatic secretion in a significant correlation with the reduction in pancreatic tissue blood flow, which suggests that reduction in the blood flow may be one of the possible mechanisms of the inhibitory action of neuropeptide Y on exocrine secretion.This work was supported by a grant from the Ministry of Education, Japan (A-61440060). 相似文献
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994.
球囊拉伤致家兔动脉粥样硬化斑块破裂及血栓形成 总被引:9,自引:1,他引:9
为建立动脉粥样硬化的兔模型并用药物触发造成斑块破裂及血栓形成,将60只雄性纯种新西兰兔随机平均分成三组:球囊损伤 高脂(1%胆固醇)组、高脂喂养组及普通饲料喂养组.喂养3个月后分别给予鲁塞尔蝰蛇毒和组胺药物触发以造成斑块破裂及血栓形成。结果发现,球囊损伤 高脂组与高脂喂养组均形成动脉粥样硬化斑块,其中球囊损伤 高脂组所形成的粥样斑块为具有较大脂质核的软斑块;药物触发后球囊损伤 高脂组存活的18只中有11只共15处发生斑块破裂及血栓形成;高脂喂养组中的19只经药物触发后仅5只共7处发生斑块破裂及血栓形成;普通饲料喂养组中未见斑块破裂及血栓形成。结果提示,在构建的动脉粥样硬化斑块的动物模型基础上,应用药物触发后能够造成斑块破裂及血栓形成。 相似文献
995.
南京市区老年人便秘患病率及其与亚健康症状关系的调查 总被引:44,自引:0,他引:44
目的 为了解南京市老年人便秘现状,以及探讨便秘与亚健康的关系。方法 采用整群抽样方法,对南京市2个街道(20个居委会)和1个老年公寓60岁以上3731名老年人进行便秘与亚健康调查。结果 南京市老年人便秘患病率为24.0%,并随年龄增长其患病率增高(P<0.01)。根据32项亚健康症状调查,便秘组(男性:28项;女性:23项)亚健康症状的发生率均高于非便秘组;前10位亚健康症状中,皮肤瘙痒和皮肤干燥为便秘者易发生的亚健康症状;便秘者平均个体有3种以上亚健康症状者(64.6%)明显高于非便秘组(42.7%,P<0.01)。结论 老年人便秘的患病率较高,便秘者较易发生亚健康症状。防治老年人便秘,对预防亚健康症状的发生及增进老年人健康非常重要。 相似文献
996.
蒲公英提取物体外抗毛囊蠕形螨活性及皮肤安全性的实验研究 总被引:1,自引:0,他引:1
目的 探讨蒲公英治疗蠕形螨病的应用价值。 方法 将粉碎的蒲公英浸泡于80%乙醇中12 h,然后85 ℃回流提取蒲公英提取液,同法制备百部提取液。取蠕形螨感染者面部皮脂,分离并鉴定蠕形螨备用。设蒲公英实验组,百部对照组和生理盐水对照组,每组蠕形螨15只,进行体外抗螨实验。pH仪测定蒲公英提取物pH值。设蒲公英试验组和75%乙醇对照组,应用健康家兔进行皮肤刺激实验和急性皮肤毒性试验。 结果 蒲公英提取物的体外杀螨时间为(1.50±0.65) min,显著短于百部提取物的体外杀螨时间(3.53±1.04) min(P<0.01),生理盐水组螨死亡时间大于120 min。蒲公英提取物的pH值为5.00±0.28,对家兔完整皮肤的刺激评分为0,破损皮肤的刺激评分为0.3,无明显毒性。 结论 蒲公英提取物具有较强的体外抗毛囊蠕形螨活性且具有皮肤安全性。 相似文献
997.
998.
韩云 杨生虎 李晓峰 杨立平 耿兴隆HAN Yun YANG Sheng-hu Li Xiao-feng YANG Li-ping GENG Xing-long 《中国内镜杂志》2015,21(1):13-16
目的探讨腹腔灌洗液中CK20m RNA的临床意义以及腹腔镜直肠癌根治术的临床应用价值。方法选择49例直肠癌手术患者,利用RT-PCR技术分别检测以上患者腹腔灌洗液中CK20m RNA表达,从而探究CK20m RNA的临床价值以及评价腹腔镜直肠癌根治术的临床实用性。结果 10例良性病变腹部手术组患者腹腔灌洗液中CK20m RNA无明显表达。39例结直肠癌患者腹腔灌洗液中可见CK20m RNA表达,术前、术中以及术后的总表达率为40.2%(47/117),且术前、术中以及术后CK20m RNA的表达率比较差异无显著性(P0.05)。17例开腹手术组和22例腹腔手术组术前、术中以及术后CK20m RNA阳性表达率的比较差异无显著性(P0.05)。结论腹腔镜结直肠癌根治术治疗结直肠癌安全有效,与开腹手术相比并不增加癌细胞局部种植的风险。 相似文献
999.
In Ku Yo Oh Sang Kwon Jin Woong Park Jong Joon Lee Jung Hyun Lee In Sik Won Sun Young Na Pil Kyu Jang Pyung Hwa Park Duck Joo Choi Yun Soo Kim Ju Hyun Kim 《Clinical and molecular hepatology》2015,21(1):32-40
Background/Aims
Liver stiffness (LS) as assessed by transient elastography (TE) can change longitudinally in patients with chronic hepatitis B (CHB). The aim of this study was to identify the factors that improve LS.Methods
Between April 2007 and December 2012, 151 patients with CHB who underwent two TE procedures with an interval of about 2 years were enrolled. Ninety-six of the 151 patients were treated with nucleos(t)ide analogues [the antiviral therapy (+) group], while the remaining 55 patients were not [the antiviral therapy (-) group]. The two groups of patients were stratified according to whether they exhibited an improvement or a deterioration in LS during the study period (defined as an LS change of ≤0 or >0 kPa, respectively, over a 1-year period), and their data were compared.Results
No differences were observed between the antiviral therapy (+) and (-) groups with respect to either their clinical characteristics or their initial LS. The observed LS improvement was significantly greater in the antiviral therapy (+) group than in the antiviral therapy (-) group (-3.0 vs. 0.98 kPa, P=0.011). In the antiviral therapy (+) group, the initial LS was higher in the LS improvement group (n=63) than in the LS deterioration group (n=33; 7.9 vs. 4.8 kPa, P<0.001). However, there were no differences in any other clinical characteristic. In the antiviral therapy (-) group, the initial LS was also higher in the LS improvement group (n=29) than in the LS deterioration group (n=26; 8.3 vs. 6.5 kPa, P=0.021), with no differences in any other clinical characteristic.Conclusions
A higher initial LS was the only factor associated with LS improvement in patients with CHB in this study. 相似文献1000.
Two compatible conversion factors for converting diameter measurements taken at different breast heights were derived for Pinus radiata using taper data from more than 3000 trees. The two breast heights used for conversion were 1.3 and 1.4 m above ground, as defined in Australia and New Zealand, two major radiata-growing countries in the world. The conversion factors were estimated through three alternative statistical methods including simple least squares regression, seemingly unrelated regression and errors-in-variables models. The three sets of estimates were almost identical and had similar conversion accuracy, although the second method was slightly better. The conversion factors were more accurate than overbark taper equations used for the same purpose. The factor was 0.9916 for converting diameter measured at 1.3 to that at 1.4 m above ground, and the inverse of this value, 1.0084, was for the vice versa. When calculating tree and stand volume and biomass using equations with diameter at a different breast height as a predictor to that of the input data, the bias, either over or under estimation, could be between 1.67% and 2.00% without conversion. These conversion factors will facilitate the sharing of data among radiata growing countries with different definitions of breast height, but more importantly it will help correct the bias in stand volume and biomass estimation caused by the seemingly negligible difference in breast height when software for forest resource management and decision support developed in one country is applied in another. Such bias when accumulated over a large management area may not be financially insignificant for an astute forest management agency. 相似文献