全文获取类型
收费全文 | 1361篇 |
免费 | 68篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 50篇 |
妇产科学 | 63篇 |
基础医学 | 83篇 |
口腔科学 | 215篇 |
临床医学 | 138篇 |
内科学 | 317篇 |
皮肤病学 | 29篇 |
神经病学 | 53篇 |
特种医学 | 69篇 |
外科学 | 185篇 |
综合类 | 5篇 |
预防医学 | 27篇 |
眼科学 | 56篇 |
药学 | 49篇 |
肿瘤学 | 56篇 |
出版年
2023年 | 18篇 |
2022年 | 21篇 |
2021年 | 55篇 |
2020年 | 16篇 |
2019年 | 45篇 |
2018年 | 42篇 |
2017年 | 31篇 |
2016年 | 49篇 |
2015年 | 56篇 |
2014年 | 77篇 |
2013年 | 91篇 |
2012年 | 98篇 |
2011年 | 106篇 |
2010年 | 49篇 |
2009年 | 56篇 |
2008年 | 94篇 |
2007年 | 106篇 |
2006年 | 80篇 |
2005年 | 69篇 |
2004年 | 67篇 |
2003年 | 57篇 |
2002年 | 63篇 |
2001年 | 17篇 |
2000年 | 21篇 |
1999年 | 21篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1979年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1433条查询结果,搜索用时 0 毫秒
41.
42.
Bülent ?zdal Murat ?z Elmas Korkmaz ?mür Atao?lu Tayfun Güng?r Mehmet Mutlu Meydanli 《International journal of surgery case reports》2014,5(11):793-795
INTRODUCTION
Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPNSTs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies.PRESENTATION OF CASE
52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy.DISCUSSION
The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial.CONCLUSION
In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment. 相似文献43.
Francisco Martínez‐Rus DDS PhD Begoña Rivera DDS PhD Mutlu Özcan Prof Dr med dent PhD Guillermo Pradíes DDS PhD 《Journal of prosthodontics》2014,23(3):232-235
The congenitally missing maxillary lateral incisor is the most common agenesis in the anterior region. There are several treatment options for this anomaly, which causes severe deficiencies: orthodontic space closure, tooth‐supported restoration, or single‐tooth implant. Each of these solutions has a high degree of success if used in the correct situation. An implant‐supported restoration with an interdisciplinary approach provides a predictable outcome. This article describes the treatment of a patient with agenesis of the maxillary left lateral incisor. After orthodontic space management, it was decided to restore the tooth with an all‐ceramic crown cemented on a zirconia custom abutment, which fractured after only 6 weeks of service. Fractographic analysis revealed that the failure was due to over‐reduction of the buccal wall to correct the labial emergence of the implant. Zirconia abutments should be designed with even wall thicknesses of at least 0.8 mm to avoid areas that may compromise functional success. 相似文献
44.
45.
Impact of Rho‐Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder 下载免费PDF全文
46.
Evaluation of Different Thickness,Die Color,and Resin Cement Shade for Veneers of Multilayered CAD/CAM Blocks 下载免费PDF全文
47.
Goia TS Leite FP Valandro LF Ozcan M Bottino MA 《The International journal of prosthodontics》2006,19(4):400-402
This study compared the microtensile bond strength of a repair resin to an alumina-reinforced feldspathic ceramic (Vitadur-alpha, Vita) after 3 surface conditioning methods: Group 1, etching with 9.6% hydrofluoric acid for 1 minute plus rinsing and drying, followed by application of silane for 5 minutes; group 2, airborne particle abrasion with 110-mm aluminum oxide using a chairside air-abrasion device followed by silane application for 5 minutes; group 3, chairside tribochemical silica coating with 30-microm SiOx followed by silane application for 5 minutes (N = 30). Group 1 presented the highest mean bond strength (19.7 +/- 3.8 MPa), which was significantly higher than those of groups 2 (10 +/- 2.6 MPa) and 3 (10.4 +/- 4 MPa) (P < .01). Scanning electron microscope analysis of the failure modes demonstrated predominantly mixed types of failures, with adhesive and/or cohesive failures in all experimental groups. 相似文献
48.
Tafur-Zelada Christie M. Carvalho Oscar Silva Filipe S. Henriques Bruno Özcan Mutlu Souza Júlio C. M. 《Clinical oral investigations》2021,25(6):3395-3408
Clinical Oral Investigations - The main aim of this study was to conduct an integrative review on the influence of the zirconia veneer thickness on the degree of conversion of resin-matrix... 相似文献
49.
Saavedra G Valandro LF Leite FP Amaral R Ozcan M Bottino MA Kimpara ET 《The International journal of prosthodontics》2007,20(2):199-201
This study aimed to evaluate the durability of adhesion between acrylic teeth and denture base acrylic resin. The base surfaces of 24 acrylic teeth were flatted and submitted to 4 surface treatment methods: SM1 (control): No SM; SM2: application of a methyl methacrylate-based bonding agent (Vitacol); SM3: air abrasion with 30-microm silicone oxide plus silane; SM4: SM3 plus SM2. A heat-polymerized acrylic resin was applied to the teeth. Thereafter, bar specimens were produced for the microtensile test at dry and thermocyled conditions (60 days water storage followed by 12,000 cycles). The results showed that bond strength was significantly affected by the SM (P < .0001) (SM4 = SM2 > SM3 > SM1) and storage regimens (P < .0001) (dry > thermocycled). The methyl methacrylate-based adhesive showed the highest bond strength. 相似文献
50.
Actinic keratoses (AKs) is a keratinocytic neoplasm that typically develops on the face of elderly patients. Little is known regarding the clinical, dermatoscopic and immunohistochemical assessments of AK using topical diclofenac therapy. We sought to determine these assessments and evaluate the efficacy of topical diclofenac gel in AK. In this prospective, open-label study, 44 patients with 66 AKs were treated for 12 weeks with topically applied diclofenac (3 % gel in 2.5 % hyaluronic acid). Immunohistopathologic analyses were performed before and after diclofenac treatment using epidermal stem cell markers such as Cytokeratin 15 (CK15), Cytokeratin 19 (CK19) and p63, in addition to proliferation markers (Bcl-2, Ki-67). Diclofenac gel was found to be effective in AK, including the hyperkeratotic type. Surprisingly, complete remission was observed at a significantly higher rate in Grade 3 lesions (p = 0.017). However, imunohistochemical and histopathologic examinations revealed that 12-week treatment periods may not be sufficient to fully cure AK. The immunohistochemical analyses revealed no change in the expression levels of CK15, CK19 and Bcl-2 following diclofenac therapy. However, the expression of Ki-67 (p = 0.042) and p63 (p = 0.030) exhibited a significant decrease after therapy. Dermatoscopy is an effective method for diagnosis of AK, and topical diclofenac sodium gel was found as an effective additional treatment modality. Since positive histopathological findings were detected in some patients even with significant remission, a 12-week treatment period should be extended even in patients presenting with positive clinical response. Importantly, anti-proliferative effects of diclofenac were demonstrated by decreased Ki-67 and p63 expression levels. 相似文献