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排序方式: 共有3598条查询结果,搜索用时 15 毫秒
71.
Kanako Terakawa Naoki Sawa Hiroki Mizuno Akinari Sekine Noriko Hayami Daisuke Ikuma Masahiro Kawada Rikako Hiramatsu Keiichi Sumida Masayuki Yamanouchi Eiko Hasegawa Tatsuya Suwabe Junichi Hoshino Keiichi Kinowaki Kenichi Ohashi Takeshi Fujii Yoshifumi Ubara 《Internal medicine (Tokyo, Japan)》2021,60(8):1237
A 74-year-old Japanese woman diagnosed with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our institute for the further examination of right-side groin pain developing in the past week. The patient was diagnosed with polymyositis (PM). Diagnostic imaging showed a mass lesion measuring 8 cm and a renal stone in the right kidney. Immediately following surgical resection of the right kidney, the patient''s serum CK decreased to the normal range. A histopathological analysis showed well-differentiated squamous cell carcinoma. In conclusion, this case showed a close relationship between the occurrence of squamous cell carcinoma and the development of PM in an ADPKD patient. 相似文献
72.
Yamasaki Yuichi Kubota Tomohiro Takei Syuji Imanaka Hiroyuki Nonaka Yukiko Kawano Yoshifumi 《Clinical rheumatology》2021,40(1):393-397
Clinical Rheumatology - Cryopyrin-associated periodic fever syndrome (CAPS) is a highly debilitating disorder, which is characterized by unregulated interleukin-1β production driven by... 相似文献
73.
Hitoshi Mori MD PhD Daisuke Kawano MD Naokata Sumitomo MD PhD FHRS Shota Muraji MD Taisuke Nabeshima MD Kenta Tsutsui MD PhD Yoshifumi Ikeda MD PhD Shiro Iwanaga MD PhD Shintaro Nakano MD PhD Toshihiro Muramatsu MD PhD Toshiki Kobayashi MD PhD Ritsushi Kato MD PhD Kazuo Matsumoto MD PhD 《Journal of cardiovascular electrophysiology》2021,32(7):1877-1883
74.
Akiyoshi Kashii Susumu Mitani Y. Kasai M. Mito Takashi Suzuki Toshiya Ito Ryoichi Tsuchiya A. Kaneto K. Tanikawa Masanobu Ishida Tsuyoshi Miura Shiro Hayashi Hiroshi Sano Keisuke Yoshida Hiroshi Ito Nobuo Okazaki Nobu Hattori Ichio Honjo Yasuo Kuroyanagi 《Journal of gastroenterology》1973,8(4):393-401
75.
Fumio Watanuki Susumu Ohwada Yasuo Hosomura Shinichi Okamura Yoshiyuki Kawashima Yoshifumi Tanahashi Sciji Nakamura Yuichi Iino Takashi Johshita Yasuo Morishita 《Journal of gastroenterology》1995,30(1):113-116
Neurofibromas in the small intestine are usually accompanied by von Recklinghausen's disease (neurofibromatosis), and usually originate in the intramuscular plexus of Auerbach. We present here a solitary neurofibroma, which caused an ileocolic intussusception, originating in the submucosal plexus of Meissner in a non-neurofibromatosis patient. To our knowledge, there is no previous report of a neurofibroma originating in the plexus of Meissner. This condition was clearly confirmed by macroscopic and microscopic evaluation. 相似文献
76.
Arrecubieta C Matsunaga I Asai T Naka Y Deng MC Lowy FD 《The Journal of infectious diseases》2008,198(4):571-575
Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection. 相似文献
77.
Immunostimulatory effects of different antilymphocyte globulin preparations: a possible clue to their clinical effect 总被引:3,自引:0,他引:3
Yoshifumi Kawano Catherine Nissen Alois Gratwohl Bruno Speck 《British journal of haematology》1988,68(1):115-119
Antilymphocyte globulin (ALG) and antithymocyte globulin (ATG) have an established role in the treatment of severe aplastic anaemia. The response rate ranges from 40% to 80%. Its mode of action is believed to be complement dependent lysis of immunocompetent cells which inhibit haemopoietic maturation. This might not be the sole mechanism. We have tested four different preparations of ALG/ATG for their mitogenic effect on normal peripheral blood cells and on enriched T-cells in vitro by 3H-thymidine incorporation. We found marked differences between the four preparations. One was strongly mitogenic and able to induce profound release of haemopoietic growth factors. This mitogenic effect could be detected in the serum of patients during ALG treatment. Clinical response rates of this preparation are about 80%. Three other preparations were of lower or no stimulatory effect. Clinical response rates with these preparations vary between 40% and 60%. From our results, we postulate that the beneficial effect of ALG could be partially due to its ability to stimulate release of haemopoietic growth factors. The mitogenicity of different ALG/ATG preparations should be tested as an in vitro parameter of clinical efficacy. 相似文献
78.
Naganuma Tatsushi Kawarada Yoshifumi Mizumoto Ryuji 《Journal of hepato-biliary-pancreatic sciences》1996,3(3):210-215
We used the Japanese Ministry of Health and Welfare criteria for acute pancreatitis to obtain a “prognosis score” for disease severity in 63 individuals with severe pancreatitis and we assessed the usefulness of these scores. To convert the Japanese criteria into a score, we excluded the CT grade classification, assigned a value of 1 point to the prognostic factors designated , and a value of 0.5 points to the prognostic factors designated , and added the number of points to obtain the “prognosis score”. The results showed a clear difference in prognosis between patients who had scores of 1.5 or less and those whose scores were 2.0 or more. These prognosis scores were useful both in rating the efficacy of treatment and in selecting the method of treatment in the early stage. To confirm the value of these scores, it will be necessary to accumulate more cases prospectively and to conduct additional assessments. 相似文献
79.
Tomizawa N Ohwada S Tanahashi Y Ikeya T Ito H Takeyoshi I Morishita Y 《Hepato-gastroenterology》2003,50(53):1625-1627
Metastatic liver tumors are considered to have a tendency for expansive growth and rarely invade the bile duct. We recently encountered a resected case of liver metastasis from rectal cancer with intraluminal growth in the extrahepatic bile duct with a successful left trisegmentectomy of the liver. A 54-year-old woman underwent a posterior total pelvic exenteration for advanced rectal cancer. Ultrasonography and computed tomography four months after the first operation demonstrated a solitary occupied lesion in the liver with dilation of the left hepatic duct. Endoscopic retrograde cholangiopancreatography disclosed a filling defect in the intra- to extrahepatic bile duct. Liver metastasis from rectal cancer with intraluminal growth in the bile duct was suspected despite a consideration of primary bile duct cancer. A left trisegmentectomy of the liver and resection of the extrahepatic bile duct with a right hepatojejunostomy were performed. The tumor had invaded the intrahepatic bile duct and had developed intraluminally in the extrahepatic bile duct. Tumor thrombi were microscopically found in the bile duct of the left caudal lobe. Liver metastasis arising from colorectal cancer with intraluminal growth in the bile duct is rare, however we encountered such a case with a successful resection involving a left trisegmentectomy of the liver. 相似文献
80.
R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men. 总被引:1,自引:0,他引:1
Masakazu Ogawa Satoshi Abe Sadatoshi Biro Masahiko Saigo Takashi Kihara Shiro Setoyama Tatsuru Matsuoka Hitoshi Toda Hiroyuki Torii Yoshihiko Atsuchi Yoshifumi Toyama Shigeki Tateishi Shinichi Minagoe Ikuro Maruyama Chuwa Tei 《Circulation journal》2004,68(6):520-525
BACKGROUND: The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial. METHODS AND RESULTS: The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1+/-40.9 U/L) than in controls (44.8+/-20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7+/-15.7%) and controls (87.0+/-9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001). CONCLUSIONS: The Q allele may be protective against premature MI. 相似文献