全文获取类型
收费全文 | 6959篇 |
免费 | 372篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 44篇 |
儿科学 | 179篇 |
妇产科学 | 99篇 |
基础医学 | 1026篇 |
口腔科学 | 254篇 |
临床医学 | 445篇 |
内科学 | 1532篇 |
皮肤病学 | 217篇 |
神经病学 | 911篇 |
特种医学 | 172篇 |
外科学 | 571篇 |
综合类 | 30篇 |
现状与发展 | 1篇 |
预防医学 | 362篇 |
眼科学 | 274篇 |
药学 | 593篇 |
中国医学 | 16篇 |
肿瘤学 | 633篇 |
出版年
2024年 | 8篇 |
2023年 | 54篇 |
2022年 | 117篇 |
2021年 | 174篇 |
2020年 | 106篇 |
2019年 | 145篇 |
2018年 | 150篇 |
2017年 | 130篇 |
2016年 | 180篇 |
2015年 | 178篇 |
2014年 | 226篇 |
2013年 | 270篇 |
2012年 | 479篇 |
2011年 | 575篇 |
2010年 | 310篇 |
2009年 | 228篇 |
2008年 | 465篇 |
2007年 | 480篇 |
2006年 | 470篇 |
2005年 | 468篇 |
2004年 | 468篇 |
2003年 | 432篇 |
2002年 | 415篇 |
2001年 | 50篇 |
2000年 | 49篇 |
1999年 | 63篇 |
1998年 | 75篇 |
1997年 | 50篇 |
1996年 | 58篇 |
1995年 | 42篇 |
1994年 | 35篇 |
1993年 | 33篇 |
1992年 | 39篇 |
1991年 | 40篇 |
1990年 | 33篇 |
1989年 | 27篇 |
1988年 | 29篇 |
1987年 | 22篇 |
1986年 | 13篇 |
1985年 | 22篇 |
1984年 | 20篇 |
1983年 | 11篇 |
1982年 | 17篇 |
1981年 | 11篇 |
1980年 | 18篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1974年 | 6篇 |
1970年 | 6篇 |
1966年 | 9篇 |
排序方式: 共有7359条查询结果,搜索用时 15 毫秒
151.
152.
Seiichi Takemasa Yoko Abe Ryoma Nakagoshi Masayuki Uesugi Yuri Inoue Makoto Gotou Yoshifumi Nanba Yoshitaka Otani 《Journal of Physical Therapy Science》2015,27(1):223-225
[Purpose] This study explored the roles of physical therapists (PTs) in introducing
assistive products, which are essential for living securely and stably at home, and
examined how PTs can fulfill these roles more efficiently and effectively. [Subjects and
Methods] A questionnaire on introducing assistive products was administered to PTs working
at randomly selected hospitals, health-care facilities for the elderly requiring long-term
care, home-visit nursing stations, and other such facilities and to PTs providing physical
therapy directly to the home-bound elderly disabled. The subjects of the study were 77 PTs
who returned valid responses. [Results] For awareness of systems for assistive product’s
introduction, PTs were more aware of the system based on the Long-Term Care (LTC)
Insurance Act than the system based on the Act on Welfare for the Home-Bound Elderly
Disabled. For PTs handling assistive product’s introduction for the home-bound elderly
disabled, approximately 91% of the respondents answered that they had handled some cases
of assistive product’s introduction, and PTs with longer clinical experience had handled
more assistive product’s introduction cases. [Conclusion] The results demonstrated that
PTs understand the work involved in introducing assistive products work well and that they
handle it. The results, however, also suggested that educational and operational
improvements are urgently required for PTs introducing assistive products essential for
the lives of the home-bound elderly disabled.Key words: Assistive products, Physical therapists, Home-bound elderly disabled 相似文献
153.
Kato M Hisatome I Tomikura Y Kotani K Kinugawa T Ogino K Ishida K Igawa O Shigemasa C Somers VK 《The American journal of cardiology》2005,96(11):1576-1578
Hyperuricemia has been associated with an increased risk for cardiovascular disease and increased mortality. However, the biologic mechanisms that link elevated serum uric acid to cardiovascular disease are uncertain. This study tested the hypothesis that elevated serum uric acid is associated with impaired endothelial function in hyperuricemic patients without any overt cardiovascular disease. Seventeen male patients with hyperuricemia (mean age 42+/-4 years) and 9 control subjects (mean age 45+/-5 years) were studied. All subjects were nonsmokers. All patients had never been treated for hyperuricemia, were on no medications, and were free of any other known diseases. Endothelial function was evaluated by flow-mediated dilation measured by ultrasound. Flow-mediated dilation was significantly impaired in patients with hyperuricemia (4.0+/-0.7%) compared with control subjects (6.4+/-0.8%) (p=0.044). Flow-mediated dilation correlated inversely with uric acid levels (r=-0.4, p=0.05). Nitrate-induced dilation was 12.3+/-1.0% in patients with hyperuricemia and 11.8+/-2.3% in control subjects (p=0.82). Impaired endothelial-dependent vasodilation is present in hyperuricemic patients even in the absence of any overt cardiovascular disease. The elevated serum uric acid, per se, may constitute a novel risk factor for endothelial dysfunction. 相似文献
154.
Rie Yamamoto Hiroshi Akazawa Kaoru Ito Haruhiro Toko Masanori Sano Noritaka Yasuda Yingjie Qin Yoko Kudo Takeshi Sugaya Kenneth R Chien Issei Komuro 《Circulation journal》2007,71(12):1958-1964
BACKGROUND: Angiotensin II (AT) is implicated in the development of cardiac remodeling, which leads to heart failure, and pharmacological inhibition of the AT type 1 (AT1) receptor has improved mortality and morbidity in patients of heart failure. The aim of this study was to elucidate the role of the AT1 receptor in disease progression in muscle LIM protein (MLP)-deficient mice, which are susceptible to heart failure because of defective function of mechanosensors in cardiomyocytes. METHOD AND RESULTS: Hearts from MLP knockout (MLPKO) mice and MLP-AT1a receptor double knockout (DKO) mice were analyzed. MLPKO hearts showed marked chamber dilatation with cardiac fibrosis and reactivation of the fetal gene program. All of these changes were significantly milder in the DKO hearts. Impaired left ventricular (LV) contractility and filling were alleviated in DKO hearts. However, the impaired relaxation and downregulated expression of sarcoplasmic reticulum calcium-ATPase 2 were unchanged in DKO hearts. CONCLUSIONS: The AT1a receptor is involved in progression of LV remodeling and deterioration of cardiac function in the hearts of MLPKO mice. These results suggest that blockade of the receptor is effective in preventing progression of heart failure in dilated cardiomyopathy. 相似文献
155.
156.
Yonehara T Yamada Y Kanasaki H Yamamoto H Fukunaga K Miyazaki K Miyamoto E 《Endocrine journal》2003,50(3):341-354
Luteinizing hormone (LH) consists of alpha- and beta-subunits, and synthesis and secretion of LH are regulated by gonadotropin-releasing hormone (GnRH). In order to examine the molecular mechanisms by which GnRH regulates LH secretion, we transfected alphaT3-1 cells with rat LHbeta-subunit cDNA under the control of a constitutive promoter and established a stable cell line of LH2 cells which secreted LH in response to GnRH. Pulsatile and continuous GnRH pretreatments increased gene expression of the alpha-subunit and synthesis of LH, and enhanced the LH secretion by brief treatments with GnRH and 56 mM KCl. The LH secretions were partially blocked by elimination of extracellular Ca2+. GnRH-induced LH secretion was completely inhibited by calphostin C (a protein kinase C inhibitor) and 1 microM wortmannin. In contrast to the GnRH induction, high K+-induced LH secretion was inhibited by KN93, a Ca2+/calmodulin-dependent protein kinase II inhibitor, as well as by 1 microM wortmannin. We also confirmed that activation of cAMP-pathway induced LH secretion, but activation of mitogen-activated protein (MAP) kinase pathway was not involved in LH secretion. These results suggest that GnRH directly regulates LH secretion as well as LHbeta-subunit synthesis, and that LH2 cells are a useful model for the study of LH secretion induced by several secretagogues. 相似文献
157.
158.
The third international meeting on genetic disorders in the RAS/MAPK pathway: Towards a therapeutic approach
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Bruce Korf Reza Ahmadian Judith Allanson Yoko Aoki Annette Bakker Emma Burkitt Wright Brian Denger Ype Elgersma Bruce D. Gelb Karen W. Gripp Bronwyn Kerr Maria Kontaridis Conxi Lazaro Corinne Linardic Reymundo Lozano Calum A. MacRae Ludwine Messiaen Sonia Mulero‐Navarro Benjamin Neel Scott Plotkin Katherine A. Rauen Amy Roberts Alcino J. Silva Sitta G. Sittampalam Chao Zhang Lisa Schoyer 《American journal of medical genetics. Part A》2015,167(8):1741-1746
159.
160.
Masashi Ninomiya Yasuteru Kondo Tetsuya Niihori Takeshi Nagashima Takayuki Kogure Eiji Kakazu Osamu Kimura Yoko Aoki Yoichi Matsubara Tooru Shimosegawa 《Hepatology research》2014,44(6):678-684
Taking nucleoside/nucleotide analogs is a major antiviral therapy for chronic hepatitis B infection. The problem with this treatment is the selection for drug‐resistant mutants. Currently, identification of genotypic drug resistance is conducted by molecular cloning sequenced by the Sanger method. However, this methodology is complicated and time‐consuming. These limitations can be overcome by deep sequencing technology. Therefore, we performed sequential analysis of the frequency of drug resistance in one individual, who was treated with lamivudine on‐and‐off therapy for 2 years, by deep sequencing. The lamivudine‐resistant mutations at rtL180M and rtM204V and the entecavir‐resistant mutation at rtT184L were detected in the first subject. The lamivudine‐ and entecavir‐resistant strain was still detected in the last subject. However, in the deep sequencing analysis, rt180 of the first subject showed a mixture in 76.9% of the methionine and in 23.1% of the leucine, and rt204 also showed a mixture in 69.0% of the valine and 29.8% of the isoleucine. During the treatment, the ratio of resistant mutations increased. At rt184, the resistant variants were detectable in 58.7% of the sequence, with the replacement of leucine by the wild‐type threonine in the first subject. Gradually, entecavir‐resistant variants increased in 82.3% of the leucine in the last subject. In conclusion, we demonstrated the amino acid substitutions of the serial nucleoside/nucleotide analog resistants. We revealed that drug‐resistant mutants appear unchanged at first glance, but actually there are low‐abundant mutations that may develop drug resistance against nucleoside/nucleotide analogs through the selection of dominant mutations. 相似文献