全文获取类型
收费全文 | 1928篇 |
免费 | 159篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 25篇 |
妇产科学 | 18篇 |
基础医学 | 287篇 |
口腔科学 | 8篇 |
临床医学 | 181篇 |
内科学 | 366篇 |
皮肤病学 | 22篇 |
神经病学 | 284篇 |
特种医学 | 78篇 |
外科学 | 313篇 |
综合类 | 15篇 |
一般理论 | 2篇 |
预防医学 | 70篇 |
眼科学 | 14篇 |
药学 | 191篇 |
中国医学 | 14篇 |
肿瘤学 | 174篇 |
出版年
2024年 | 4篇 |
2023年 | 22篇 |
2022年 | 34篇 |
2021年 | 81篇 |
2020年 | 42篇 |
2019年 | 65篇 |
2018年 | 74篇 |
2017年 | 50篇 |
2016年 | 55篇 |
2015年 | 53篇 |
2014年 | 81篇 |
2013年 | 108篇 |
2012年 | 160篇 |
2011年 | 124篇 |
2010年 | 74篇 |
2009年 | 90篇 |
2008年 | 123篇 |
2007年 | 128篇 |
2006年 | 104篇 |
2005年 | 85篇 |
2004年 | 80篇 |
2003年 | 70篇 |
2002年 | 58篇 |
2001年 | 32篇 |
2000年 | 22篇 |
1999年 | 30篇 |
1998年 | 15篇 |
1997年 | 11篇 |
1996年 | 18篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1993年 | 6篇 |
1992年 | 13篇 |
1991年 | 14篇 |
1990年 | 26篇 |
1989年 | 13篇 |
1988年 | 14篇 |
1987年 | 18篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1979年 | 4篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1973年 | 6篇 |
1970年 | 3篇 |
1967年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有2098条查询结果,搜索用时 382 毫秒
31.
32.
Richard J. Reynolds Ana I. Vazquez Vinodh Srinivasasainagendra Yann C. Klimentidis S. Louis BridgesJr. David B. Allison Jasvinder A. Singh 《Rheumatology international》2016,36(2):263-270
We hypothesized that serum urate-associated SNPs, individually or collectively, interact with BMI and renal disease to contribute to risk of incident gout. We measured the incidence of gout and associated comorbidities using the original and offspring cohorts of the Framingham Heart Study. We used direct and imputed genotypes for eight validated serum urate loci. We fit binomial regression models of gout incidence as a function of the covariates, age, type 2 diabetes, sex, and all main and interaction effects of the eight serum urate SNPs with BMI and renal disease. Models were also fit with a genetic risk score for serum urate levels which corresponds to the sum of risk alleles at the eight SNPs. Model covariates, age (P = 5.95E?06), sex (P = 2.46E?39), diabetes (P = 2.34E?07), BMI (P = 1.14E?11) and the SNPs, rs1967017 (P = 9.54E?03), rs13129697 (P = 4.34E?07), rs2199936 (P = 7.28E?03) and rs675209 (P = 4.84E?02) were all associated with incident gout. No BMI by SNP or BMI by serum urate genetic risk score interactions were statistically significant, but renal disease by rs1106766 was statistically significant (P = 6.12E?03). We demonstrated that minor alleles of rs1106766 (intergenic, INHBC) were negatively associated with the risk of incident gout in subjects without renal disease, but not for individuals with renal disease. These analyses demonstrate that a significant component of the risk of gout may involve complex interplay between genes and environment. 相似文献
33.
Amoore JN Lemesre Y Murray IC Mieke S King ST Smith FE Murray A 《Journal of hypertension》2008,26(1):35-43
OBJECTIVE: To explore the differences between oscillometric and auscultatory measurements. METHOD: From a simulator evaluation of a non-invasive blood pressure (NIBP) device regenerating 242 oscillometric blood pressure waveforms from 124 subjects, 10 waveforms were selected based on the differences between the NIBP (oscillometric) and auscultatory pressure measurements. Two waveforms were selected for each of five criteria: systolic over and underestimation; diastolic over and underestimation; and close agreement for both systolic and diastolic pressures. The 10 waveforms were presented to seven different devices and the oscillometric-auscultatory pressure differences were compared between devices and with the oscillometric waveform shapes. RESULTS: Consistent patterns of waveform-dependent over and underestimation of systolic and diastolic pressures were shown for all seven devices. The mean and standard deviation, for all devices, of oscillometric-auscultatory pressure differences were: for the systolic overestimated waveforms, 36 +/- 28/-6 +/- 3 and 23 +/- 2/-1 +/- 3 mmHg (systolic/diastolic differences); for systolic underestimated waveforms, -21 +/- 5/-4 +/- 3 and -11 +/- 4/-3 +/- 3 mmHg; for diastolic overestimated waveforms, 3 +/- 4/12 +/- 5 and 17 +/- 6/10 +/- 2 mmHg; for diastolic underestimated waveforms, 1 +/- 4/-22 +/- 4 and -9 +/- 6/-29 +/- 4 mmHg; and for the two waveforms with good agreement, 0 +/- 6/0 +/- 3 and -2 +/- 4/-4 +/- 3 mmHg. Waveforms for which devices showed good oscillometric and auscultatory agreement had smooth envelopes with clearly defined peaks, compared with the broader plateau and complex shapes of those waveforms for which devices over or underestimated pressures. CONCLUSION: By increasing the understanding of the characteristics and limitations of the oscillometric method and the effects of waveform shape on pressure measurements, simulator evaluation should lead to improvements in NIBP devices. 相似文献
34.
35.
Alize Raimbeau Marc-Antoine Pistorius Yann Goueffic Jrme Connault Pierre Plissonneau-Duquene Blandine Maurel Jean Reignier Karim Asehnoune Mathieu Artifoni Quentin Didier Giovanni Gautier Jean-Nel Trochu Bertrand Rozec Chan NGohou Ccile Durant Pierre Pottier Julien Denis Le Sve Nicolas Brebion Christian Agard Olivier Espitia 《Medicine》2021,100(20)
Upper extremity digital ischaemia (UEDI) is a rare heterogeneous condition whose frequency is 40 times less than that of toe ischaemia. Using a large cohort, the aim of this study was to evaluate aetiologies, prognosis and midterm clinical outcomes of UEDI.All patients with UEDI with or without cutaneous necrosis in a university hospital setting between January 2000 to December 2016 were included. Aetiologies, recurrence of UEDI, digital amputation and survival were analyzed retrospectively.Three hundred twenty three patients were included. UEDI due to cardio-embolic disease (DICE) was the highest occurring aetiology with 59 patients (18.3%), followed by DI due to Systemic Sclerosis (SSc) (16.1%), idiopathic causes (11.7%), Thromboangiitis obliterans (TAO) (9.3%), iatrogenic causes (9.3%), and cancer (6.2%). DICE patients tended to be older and featured more cases with arterial hypertension whereas TAO patients smoked more tobacco and cannabis. During follow-up, recurrences were significantly more frequent in SSc than in all other tested groups (P < .0001 vs idiopathic and DICE, P = .003 vs TAO) and among TAO patients when compared to DICE patients (P = .005). The cumulated rate of digital amputation was higher in the SSc group (n = 18) (P = .02) and the TAO group (n = 7) (P = .03) than in DICE (n = 2).This retrospective study suggests that main aetiologies of UEDI are DICE, SSc and idiopathic. This study highlights higher frequency of iatrogenic UEDI than previous studies. UEDI associated with SSc has a poor local prognosis (amputations and recurrences) and DICE a poor survival. UEDI with SSc and TAO are frequently recurrent. 相似文献
36.
Clément Medrinal Guillaume Prieur Yann Combret Aurora Robledo Quesada David Debeaumont Tristan Bonnevie Francis Edouard Gravier Elise Dupuis Lozeron Jean Quieffin Olivier Contal Bouchra Lamia 《Archives of physical medicine and rehabilitation》2018,99(8):1454-1461
Objective
To evaluate the effect of quadriceps functional electrical stimulation (FES)-cycling on exertional oxygen uptake (o2) compared with placebo FES-cycling in patients with chronic obstructive pulmonary disease (COPD).Design
A randomized, single-blind, placebo-controlled crossover trial.Setting
Pulmonary rehabilitation department.Participants
Consecutive patients (N=23) with COPD Global Initiative for Chronic Obstructive Lung Disease stage 2, 3, or 4 (mean forced expiratory volume during the first second, 1.4±0.4L [50.3% predicted]) who had recently begun a respiratory rehabilitation program.Intervention
Two consecutive 30-minute sessions were carried out at a constant load with active and placebo FES-cycling.Main Outcome Measures
The primary outcome was mean o2 during the 30-minute exercise session. The secondary outcomes were respiratory gas exchange and hemodynamic parameters averaged over the 30-minute endurance session. Lactate values, dyspnea, and perceived muscle fatigue were evaluated at the end of the sessions.Results
FES-cycling increased the physiological response more than the placebo, with a greater o2 achieved of 36.6mL/min (95% confidence interval [CI], 8.9–64.3mL/min) (P=.01). There was also a greater increase in lactate after FES-cycling (+1.5mmol/L [95% CI, .05–2.9mmol/L]; P=.01). FES-cycling did not change dyspnea or muscle fatigue compared with the placebo condition.Conclusions
FES-cycling effectively increased exercise intensity in patients with COPD. Further studies should evaluate longer-term FES-cycling rehabilitation programs. 相似文献37.
By introducing bulky 2-phenylethyl groups into sulfur-rich electron acceptors, 5,5′-bithiazolidinylidene-2,2′-dione-4,4′-dithione and 5,5′-bithiazolidinylidene-2,4,2′,4′-tetrathione, electron transport with the mobility of 0.27 cm2 V−1 s−1 with ambient and long-term stability is achieved in thin-film transistors. Bulky groups destroy the intermolecular S–S network, but the long-term transistor stability is maintained. Here, benzyl groups realize one-dimensional stacking structures, whereas 2-phenylethyl groups lead to herringbone structures.Performance and long-term air stability of birhodanine-based n-channel transistors are improved by introducing phenylethyl moieties. 相似文献
38.
39.
40.
Aurlie Plessier Marie‐Hlne Denninger Yann Consigny Fabienne Pessione Claire Francoz Franois Durand Sven Francque Annie Bezeaud Laurence Chauvelot‐Moachon Didier Lebrec Dominique‐Charles Valla Richard Moreau 《Liver international》2003,23(6):440-448
Background: In patients with cirrhosis, severe sepsis may stimulate the extrinsic coagulation pathway resulting in thrombin generation and fibrin formation. Aims: To compare 23 patients with severe sepsis to 13 infected patients without severe sepsis and 18 patients without infection. Methods: Zymogen forms of clotting factors involved in the extrinsic pathway (i.e., factors VII+X, V, prothrombin), and the presence of soluble fibrin were assessed. Results: Zymogen forms of clotting factors were significantly lower, while Child–Pugh score and the proportion of patients with soluble fibrin were higher in the severe‐sepsis group than in the other groups. Decreased zymogen levels were independently correlated with an elevated Child–Pugh score and the presence of severe sepsis. In the severe‐sepsis group, after adjustment for the severity of cirrhosis, decreased zymogen levels were associated with significant increases in the relative risk ratios of in‐hospital death. Conclusions: Cirrhotic patients with severe sepsis have decreased blood levels of zymogen forms of factors VII+X, V, and prothrombin, which may be due not only to the severity of cirrhosis but also, at least in part, to the consumption of these zymogens by the extrinsic coagulation pathway. 相似文献