全文获取类型
收费全文 | 118篇 |
免费 | 2篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 3篇 |
基础医学 | 9篇 |
口腔科学 | 5篇 |
临床医学 | 9篇 |
内科学 | 22篇 |
皮肤病学 | 1篇 |
神经病学 | 9篇 |
外科学 | 25篇 |
预防医学 | 1篇 |
药学 | 7篇 |
肿瘤学 | 18篇 |
出版年
2021年 | 1篇 |
2016年 | 4篇 |
2014年 | 3篇 |
2013年 | 1篇 |
2010年 | 3篇 |
2009年 | 3篇 |
2008年 | 2篇 |
2007年 | 1篇 |
2006年 | 6篇 |
2005年 | 1篇 |
2004年 | 6篇 |
2003年 | 7篇 |
2002年 | 3篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 4篇 |
1997年 | 9篇 |
1996年 | 10篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1978年 | 4篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1959年 | 3篇 |
1958年 | 1篇 |
1957年 | 5篇 |
1956年 | 5篇 |
1955年 | 4篇 |
1954年 | 7篇 |
1948年 | 1篇 |
排序方式: 共有120条查询结果,搜索用时 281 毫秒
71.
RITSUKO KATAHIRA ICHIRO UMEMURA MICHIHIRO TAKAI KYOKO ODA TOSHIKAZU OKADA ATSUKO Y. NOSAKA 《Chemical biology & drug design》1998,51(2):155-164
IRL 1620 {suc-[Glu9,Ala11,15]ET-1(8-21)} is a potent and specific agonist for the ETB receptor. Five analogs of IRL 1620 were synthesized in this study. These were all C-terminal linear peptides of endothelin 1 (ET-1) comprising 14 amino acid residues and exhibiting highly potent ETB receptor binding affinities. The peptides consisted of three pairs and each component of the pairs differed from its partner in only the 18th residue, i.e. Asp was replaced by Gly. The replacements resulted in more than a 10-fold increase in affinity to the ETA receptor. The structures of these peptides were investigated in the presence of phospholipid vesicles (dipalmitoyl phosphatidylcholine) by NMR spectroscopy. By the replacement of Asp by a less bulky Gly, the C-terminal tripeptide region folded back toward the helical region, making it shorter than the Asp-substituted peptide helical region. Such a folded conformational feature may explain the increased binding affinity to ETA receptor. 相似文献
72.
KOHSUKE UCHIDA NORIOMI MIYAO NAOYA MASUMORI ATSUSHI TAKAHASHI TOSHIRO ODA MASAHIRO YANASE HIROSHI KITAMURA NAOKI ITOH MASAAKI SATO TAIJI TSUKAMOTO 《International journal of urology》2002,9(1):19-23
OBJECTIVES: We evaluated clinical features and predictive factors for the recurrence of renal cell carcinoma (RCC) developing more than 5 years after nephrectomy. METHODS: We retrospectively reviewed 239 patients with RCC who underwent surgery for the primary lesion. To identify factors that affected recurrence more than 5 years after nephrectomy (delayed recurrence) and its clinical outcomes, we performed a multivariate analysis using Cox's proportional hazards model and a survival study. RESULTS: Recurrence developing within 5 years after nephrectomy (early recurrence) was found in 57 patients and delayed recurrence in 11 patients. The multivariate analysis revealed no clinical and pathologic features influencing delayed recurrence in 114 patients who survived more than 5 years after nephrectomy without having early recurrence. The patients with delayed recurrence showed better clinical outcomes than those with early recurrence when the rate was determined from the time of recurrence. CONCLUSIONS: Although delayed recurrence is not a rare event for patients with RCC, no clinical and pathologic factors at the time of the initial treatment can predict the recurrence. Patients who are free of recurrence for more than 5 years after surgery for a primary lesion should be carefully followed up for delayed recurrence. 相似文献
73.
74.
75.
76.
77.
78.
79.
TATSUYA MOROOKA HIROMI MATANO AKIKO UMEDA TEIICHI ODA KAZUNOBU AMAKO MOHAMED A KARMALI 《Pediatrics international》1995,37(4):469-473
We examined sera from 10 patients with hemolytic uremic syndrome (HUS) and 51 controls, with and without diarrhea, for antibodies to Escherichia coli lipopolysaccharides (LPS) O157, O111 and O26 using the indirect hemagglutination (IHA) assay. A significant rise (to a titer of ≥ 2560) in IHA antibody to O157 LPS was detected in eight of the 10 HUS patients, to O111 in two patients, one of whom showed concomitantly an antibody rise to O157, but to O26 in no patients. The IHA titers fell rapidly after the acute phase of the illness. Of the control sera 15 (29.4%) non-specifically agglutinated uncoated sheep red blood cells (SRBC) at a titer of ≥80, six (3.9%) at ≥320 and the maximum was 640. In spite of the relatively low level of non-specific agglutination the IHA appeared to be a useful screening method to identify verotoxin-producing E. coli infections at the early stage of HUS because the titers were clearly higher than non-specific agglutination and the assay is easy to perform and gives results quickly. Artificial carriers are being considered for use in place of SRBC to diminish the non-specific hemagglutination. 相似文献
80.