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21.
SHIKIFUMI KITAZAWA IKUO JOHNO TOKUZO MINOUCHI YOKO ITO JUTARO OKADA 《The Journal of pharmacy and pharmacology》1977,29(1):585-588
Uncoated caffeine tablets of four different hardnesses were tested for dissolution rate by the Sartorius (S.S. method) and by the rotating basket method of the U.S.P. XVIII. In both methods the dissolution rate decreased with increasing hardness, and the rate obtained with the S.S. method was always less than that by the U.S.P. method. This result cannot be explained as being due only to the difference in the volume of dissolution medium. Also it was difficult to ensure that the characteristic changes in the process of dissolution paralleled the curves obtained from a plot of % caffeine dissolved vs time. Accordingly, the dissolution rate constants were calculated from the slope of each straight line in a plot of In W∞/(W∞ - W) vs time. 相似文献
22.
YUMIKO ARAI TORU HOSOKAWA AKIRA FUKAO YOKO IZUMI SHIGERU HISAMICHI 《Addiction (Abingdon, England)》1997,92(8):1023-1034
Abstract Aims . The aim of our study was to determine whether the previously reported findings also apply to a general population in Japan and whether, among current smokers, such personality characteristics can be correlated with the age they started to smoke and their present daily consumption of cigarettes . Design . Cross-sectional survey . Setting . Miyagi prefecture, in northern Japan . Participants . 20 538 residents in Miyagi, aged 40-64 years . Measurement . A self-administered questionnaire involving smoking status (current, ex- and non-smokers) and patterns and the Japanese version of the short-form Eysenck Personality QuestionnaireRevised (EPQ-R) . Findings . (1) Current and ex-smokers were higher on Extraversion and Psychoticism than non-smokers for both genders. (2) Heavy smokers were higher on Psychoticism than light smokers and those who started to smoke prior to the legally permitted age were higher on Psychoticism than those who did not . Conclusions . (1) Our study confirmed that the findings which had been previously reported in selected samples in western countries also apply to a general population in Japan; (2) current smokers were found to be heterogeneous in terms of Psychoticism when the age they started to smoke and their present daily consumption of cigarettes were taken into account. 相似文献
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The simultaneous effects of several variables on the secondary sex ratio have been examined using data from over 3.7 million births which occurred in Japan during 1975--6. A weak and negative association between sex ratio and birth order was observed but it was not significant in the statistical sense. A negative effect of paternal age--birth order interaction was obtained when maternal age was controlled. The quadratic model is much more powerful than the linear model in explaining the sex ratio variability. 相似文献
25.
YOSHIO OKADA YUKO TSUDA YOKO NAGAMATSU UTAKO OKAMOTO 《Chemical biology & drug design》1984,24(4):347-358
Stereoisomers of specific substrates for SFP and ELP, Suc-L-Tyr-L-Leu-L-Val-pNA and Suc-L-Ala-L-Tyr-L-Leu-L-Val-pNA, were synthesized by the conventional solution method. Suc-L-Tyr-D-Leu-D-Val-pNA was found to be an effective and specific inhibitor of SFP and ELP. Suc-L-Tyr-L-Leu-L-Val-Pipe and Suc-L-Tyr-D-Leu-D-Val-Pipe inhibited only SFP very slightly and showed no inhibitory effect on ELP. Both Dan-L-Tyr-L-Leu-L-Val-pNA and Dan-L-Tyr-D-Leu-D-Val-pNA exhibited an inhibitory effect on both SFP and ELP. 相似文献
26.
YOKO SHOJI TADASHI FUKUMURA MASATAKA KUDO AKIRA YANAGAWA JINGORO SHIMADA YUTAKA MIZUSHIMA 《The Journal of pharmacy and pharmacology》1994,46(8):643-646
Abstract— The effects of a topical preparation of mycophenolic acid on the experimental allergic contact dermatitis induced by dinitrofluorobenzene was investigated. Visual assessment of skin reactions showed significant efficacy of a topical preparation of mycophenolic acid. This efficacy appeared from the early stage and endured up to 3 days. Morphological changes in the epidermis and dermis layers of animals treated with a mycophenolic acid cream were moderate compared with that in animals treated with vehicle only. In particular, hyperkeratosis was strongly suppressed. Since suppression of inflammatory cell infiltration was also observed, this efficacy might reach to the epidermis and dermis layer. 相似文献
27.
YOSHIO OKADA YUKO TSUDA YOKO NAGAMATSU UTAKO OKAMOTO 《Chemical biology & drug design》1981,17(5):560-564
Two peptide anilides, Suc-Tyr-Leu-Val-pNA (III) and Ac-Ser-His-I.eu-Val-pNA (V) were synthesized by the conventional method with the object of obtaining specific substrates for human spleen fibrinolytic proteinase (SFP). The Kcat/Km values for hydrolysis of HI and V by SFP were 22 64 7 and 2 700, respectively. On the contrary, the Kcat/Km values for hydrolysis of III and V by porcine pancreatic elastase were 21 and 9, respectively. 相似文献
28.
The death rates due to alcoholism in Japan were analysed forthe period 19501978. The alcoholism death rates for bothsexes increased each year. The alcoholism death rates were closelyrelated to the levels of alcohol consumption. Among both sexes the lowest age-adjusted death rates were observedin married persons and the highest death rates in divorced persons. Geographical variations in the alcoholism death rates were analysed;they were also correlated with alcohol consumption levels. Themean ages at death for alcoholics were 50 for men and 48 forwomen; the mean ages remained constant during the period ofstudy. 相似文献
29.
HIROSHI OKADA HITOSHI FUJIOKA NOBORU TATSUMI MASANORI KANZAKI YOKO INABA MASATO FUJISAWA KAZUO GOHJI SOICHI ARAKAWA SADAO KAMIDONO 《The Journal of urology》1998,159(3):848-850
Purpose
We determined a rational strategy for treatment of patients with retrograde ejaculation in the era of modern assisted reproduction technology.Materials and Methods
In 7 consecutive patients medical treatment or retrieval of spermatozoa from the bladder was performed at a male infertility clinic.Results
Antegrade ejaculation was restored in 3 patients, and spermatozoa were retrieved from the bladder and used for assisted reproduction in 3. Spermatozoa with good oolemma penetrating ability were collected by seminal vesicle massage.Conclusions
Modern assisted reproduction technology is a powerful treatment option for retrograde ejaculation when combined with a technique to retrieve spermatozoa of good quality from the bladder. 相似文献30.
YOKO HAMAI TOMOYUKI FUJII TAKAHIRO YAMASHITA AKINORI MIKI SHIRO KOZUMA DANIEL E. GERAGHTY YUJI TAKETANI 《American journal of reproductive immunology (New York, N.Y. : 1989)》1998,40(6):408-413
PROBLEM: In search for pathogenesis of recurrent abortion, we examined whether lymphocytes/macrophages from women with recurrent abortion exhibited an aberrant ability to release cytokines upon the direct contact of human leukocyte antigen (HLA)-G. METHOD OF STUDY: The amounts of cytokines released from peripheral blood mononuclear cells (PBMCs) from women with recurrent abortion were compared with those from normal multiparous women or normal nulligravidous women when cocultured with or without HLA-G-expressing target cells. RESULTS: When cocultured with HLA-G-expressing target cells, the amount of interleukin-1β released from PBMCs was increased in recurrent aborters whereas it decreased in both normal multiparous and nulligravidous women. The amount of interleukin-3 released from PBMCs did not differ with or without HLA-G-expressing cells in recurrent aborters, whereas it increased in the presence of HLA-G-expressing cells in normal controls. The amount of tumor necrosis factor-α released from PBMCs was decreased in the presence of HLA-G-expressing cells in both recurrent aborters and normal controls. CONCLUSION: The aberrant reaction of maternal lymphocytes/macrophages in releasing cytokines upon the contact of HLA-G expressed on trophoblasts may impact negatively on trophoblastic growth, which may be pathogenic in recurrent abortion. 相似文献