Prevalence of cardiovascular disease risk factors in a southwestern Native American tribe.

A cross-sectional study was conducted among the Pascua Yaqui Indian tribe in Tucson, AZ, in 1990 to document the prevalence of cardiovascular disease risk factors. Cardiovascular disease is the leading cause of mortality for Native Americans and for members of the Pascua Yaqui tribe specifically. A total of 230 randomly selected adults, ages 25-65 years, who were listed as members on the tribal roll, participated, resulting in a 73-percent participation rate for those contacted. The five risk factors studied included diabetes, hypertension, hypercholesterolemia, obesity, and smoking. Only 14 percent of participants had none of the risk factors; 52 percent had two or more factors. Obesity was the most prevalent, being present in 69 percent of the women and 40 percent of the men, followed by diabetes, 35 percent of men and 39 percent of women. Twenty-six percent of the population had hypertension, and 43 percent of men were smokers, compared with 24 percent of women. Hypercholesterolemia was present in 19 percent of men and 14 percent of women. The rates of diabetes, obesity, hypertension, and smoking documented in this tribe are relatively high and can serve as a baseline for evaluating future prevention efforts.     

Impact of exclusion criteria on case mix, outcome, and length of stay for the severity of disease scoring methods in common use in critical care

OBJECTIVE: To identify the exclusion criteria for the major severity of disease scoring methods in critical care and to investigate the impact of the exclusion criteria on the case mix, outcomes and length of stay for admissions to intensive care units (ICUs) in England, Wales and Northern Ireland. DESIGN: Cohort study-analysis of prospectively collected data. SETTING: 127 adult, general (mixed medical/surgical) ICUs in England, Wales and Northern Ireland. PATIENTS: 120,503 admissions between 1995 and 2001. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Thirteen different exclusion criteria were identified from the original methodological/validation papers and data collection manuals for APACHE II, APACHE III, SAPS II and MPM II. Application of the original exclusion criteria for the four, major severity of disease scoring methods resulted in exclusion of between 11.5% and 14.6% of admissions. Hospital mortality for the overall cohort was 29.0% but ranged from 4.7% to 50.1% among those groups excluded. After application of the exclusion criteria for each scoring method, there was little difference in overall hospital mortality or median ICU and hospital length of stay for the included admissions when compared with the original cohort. At the level of individual ICUs, there were differences in hospital mortality before and after exclusions-minimum -3.1% to maximum 9.5% (APACHE II), minimum -2.8% to maximum 9.4% (APACHE III), minimum -3.1% to maximum 16.1% (SAPS II) and minimum -3.1% to maximum 16.5% (MPM II). The mean difference across individual ICUs was -0.5 % (95% CI -0.7% to -0.2%) for APACHE II, -0.2% (95% CI -0.2% to 0.1%) for APACHE III, 2.0% (95% CI 1.7% to 2.4%) for SAPS II and 2.1% (95% CI 1.7% to 2.5%) for MPM II. SAPS II and MPM II showed systematic variation. A survey of the literature found wide variation in the exclusion criteria reported in subsequent, published research using a single severity of disease scoring method (APACHE II). CONCLUSIONS: Exclusion criteria used in critical care research are often ill-defined and poorly reported. More attention to the choice of exclusion criteria and their effect on the reported results is essential. We hope this study will raise the need for both better reporting of exclusion criteria applied in studies and promote the need for a common set of explicit exclusion criteria for these methods.     

Three-dimensional shape of a Goormaghtigh cell and its contact with a granular cell in the rabbit kidney

Summary Goormaghtigh cells of the JGA are characterized by an extensive cellular ramification. In order to elucidate the shape and arrangement of the cell processes a three-dimensional model of a Goormaghtigh cell and of an adjacent granular cell has been constructed based on electron micrographs of a series of ultrathin sections.The model shows that a Goormaghtigh cell has the shape of a flatly pressed cylinder with both ends splitting up into a bunch of parallel processes. The processes maintain a close neighboring position and do not intermingle with processes of other Goormaghtigh cells. This feature is most puzzling when considering that Goormaghtigh cells and their processes are extensively connected by gap junctions. Even processes belonging to the same cell are electrically coupled with each other through gap junctions.The granular cells are clearly different in shape from Goormaghtigh cells. In granular cells bunches of processes are lacking. Granular cells obviously ramify into a few, large processes.The present findings are consistent with the assumption of a functionally central position of Goormaghtigh cells within the feedback mechanism of the JGA.     

A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal

Neonatal opioid withdrawal often requires treatment but there have been few recent studies of current pharmacological interventions to guide treatment. This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens. The outcome variables examined were time to resolution of withdrawal symptoms, rate of decrease in symptom severity, and length of hospital stay. There were no observed differences in outcome variables between the two treatment groups and side effect profiles were similar. Dosages, dosage intervals, and tapering regimens were consistent with American Academy of Pediatrics recommendations. Although the sample size is small and standardized regimens were not used, this study provides preliminary data about dosing levels and dosing intervals of these two pharmacologic treatment agents. Both groups of infants had favorable outcomes, although given the variation in treatment regimens it is difficult to draw an equation of equivalency. These results are applicable to the design of future studies of pharmacological interventions.