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排序方式: 共有406条查询结果,搜索用时 15 毫秒
91.
Paget disease of the nipple: radiologic-pathologic correlation 总被引:1,自引:0,他引:1
92.
Benzimra RE; Antao AJ; Donovan KL; Williams AJ 《QJM : monthly journal of the Association of Physicians》1998,91(6):417-422
Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura
(TTP) are conditions in which thrombocytopenia and microangiopathic
haemolytic anaemia are associated with organ damage due to thrombotic
microangiopathy (TMA). The prognosis for adults with HUS is variable, with
some patients presenting with an acute illness from which a full recovery
is made, whilst others develop irreversible renal failure. Evidence of
retinal ischaemia was noted on presentation in a normotensive patient with
irreversible renal failure due to HUS. This study examined prospectively
the optic fundi of all patients who subsequently presented to a single
adult renal unit (catchment population approximately 700,000) with HUS.
Eleven patients presented with HUS over 12 years (1985-1997). Six patients
with irreversible renal failure had retinal abnormalities either at the
time or within a few days of initial presentation. The other five patients
whose renal function recovered did not develop retinal changes during the
course of their illness. Retinal ischaemia associated with TMA is a poor
prognostic sign in adults with HUS.
相似文献
93.
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95.
U Poddar BR Thapa K Vaiphei KL Rao SK Mitra K Singh 《Archives of disease in childhood》1998,78(3):264-266
The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected to histological examination. Mean age was 7.7 years, with a male preponderance (3:1). Presentation was with rectal bleeding (94%), pallor (65%), stunted growth (53%), and oedema (47%), and the mean (SD) duration of symptoms was 33 (27) months. None had a positive family history or any congenital anomaly. Two children had six polyps up to the transverse colon; the rest had numerous polyps all over the colon. All children had juvenile polyps on histology and 10 (59%) had adenomatous changes (dysplasia). Total colectomy was done in six for intractable symptoms. Colon clearance was achieved in eight after an average 3.4 polypectomy sessions, and three were still on the polypectomy programme. In conclusion, juvenile polyposis is commonly associated with low grade dysplasia. Serial colonoscopic polypectomy is effective but colectomy is required for intractable symptoms and when clearance of the colon is not possible. 相似文献
96.
97.
AC Fenton KL Woods R Leanage M Abu-Harb MI Levene DH Evans DJ Field 《Acta paediatrica (Oslo, Norway : 1992)》1992,81(6-7):498-503
Sick preterm infants may, under certain conditions, demonstrate blood pressure passive cerebral blood flow in response to changes in arterial carbon dioxide tension. Blood pressure in turn depends on cardiac output and peripheral resistance. A Doppler technique for assessing cardiac output compared favourably in terms of reproducibility to a thermodilution technique in a group of infants undergoing cardiac catheterization for congenital heart disease. Doppler was subsequently used to monitor changes in cardiac output following an increase in arterial carbon dioxide tension of 1 kPa in 25 ventilated preterm infants. Blood pressure increased significantly (p = 0.006). However, heart rate did not change significantly (p = 0.16) and, in addition, both stroke and minute volume decreased (p = 0.023, p = 0.02, respectively). This suggests that accompanying changes in components of peripheral resistance exert important effects on blood pressure in the preterm neonate in response to changes in arterial carbon dioxide tension. 相似文献
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KL Goh PL Cheah YM Tan M Rosmawati KT Ong YL Lo SC Chin 《Journal of digestive diseases》2001,2(3):137-141
OBJECTIVE : To determine and compare the efficacy of 5‐day t.d.s and 7‐day b.d. treatment regimens comprising lansoprazole, clarithromycin and amoxicillin in the eradication of Helicobacter pylori. METHODS : Patients with unequivocal evidence of H. pylori infection based on histology and rapid urease tests of both antrum and corpus biopsies were recruited for the study. The study was a randomized, investigator‐blind, comparative study. Patients received either 500 mg clarithromycin t.d.s. and 500 mg amoxicillin t.d.s. for 5 days (LAC5) or 500 mg clarithromycin b.d. and 500 mg amoxicillin b.d. for 7 days (LAC7) together with 30 mg lansoprazole (both groups) daily for either 5 or 7 days, depending on the treatment group. Patients were assessed for the successful eradication of H. pylori, defined as the absence of bacteria based on histology and urease tests on both antral and corporeal biopsies, carried out at least 4 weeks after completion of the therapy. RESULTS : One hundred and eight patients were recruited for the study. In the LAC5 treatment group, four patients failed to return for follow up and in the LAC7 group, two failed to return for follow up and two were not compliant with medications. Eradication rates based on an intention‐to‐treat analysis were: 46/54 for LAC5 (85.2%; 95% CI = 72.9–93.4) and 47/54 for LAC7 (87.0%; 95% CI = 75.1–94.6). Based on a per protocol analysis, the rates were: 46/50 for LAC5 (92.0%; 95% CI = 80.8–97.8) and 47/50 for LAC7 (94.0%; 95% CI = 83.5–98.7). Both treatment regimens were convenient for patients and except for two patients in the LAC7 group, all patients reported taking 100% of all prescribed medications. The side‐effects encountered were uniformly mild and no patient discontinued treatment because of intolerance to medications. The most common side‐effects were altered taste (LAC5 64.7%; LAC7 78.8%). Diarrhea, nausea and anorexia were reported in a minority of patients. CONCLUSIONS : Both the LAC5 t.d.s. and the LAC7 b.d. treatment regimens were well tolerated by patients and were highly effective in the eradication of H. pylori. 相似文献