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131.
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Pietro G. di Summa MD PhD Gianluca Sapino MD Patrice Zaugg MD Wassim Raffoul MD David Guillier MD 《Microsurgery》2020,40(7):814-817
When costal graft is contraindicated or refused by the patient, autologous total/subtotal auricular reconstruction represent a real challenge as limited surgical options has been described. Aim of present report is to offer a novel possible autologous reconstruction of the ear frame using a chimeric free medial femoral condyle (MFC) flap. We present a case of a 29 years old patient who had total loss of the upper 2/3 of the right ear after bombing in Somalia and secondary infected condritis (considered a relative contraindication for costal cartilage graft). The MFC flap was harvested with a chimeric skin paddle (7 × 5 cm), a thin sheet of femoral cortex (6.5 × 8 cm) was used as basal ear frame, while part of the contralateral concha was trimmed as support for the helix, with the periosteal component of the flap wrapping around the whole framework. The chimeric skin paddle assured the retroauricular skin coverage, while the anterior part of the construct was covered by a thinned dermal flap. Postoperative course was uneventful. A defatting procedure of the posterior skin paddle was performed at 2 months post-op. At 6 months post-op, the patient was satisfied with the result, could wear glasses and was socially integrated. This new application of the free chimeric MFC flap, despite being not the primary choice for ear reconstruction, guaranteed satisfactory results in terms of ear shape and infection prevention and may be considered when ordinary cartilage rib reconstruction is refused, contraindicated, or failed. 相似文献
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135.
David D’Andrea Surena Matin Peter C. Black Firas G. Petros Homayoun Zargar Colin P. Dinney Michael S. Cookson Wassim Kassouf Marc A. Dall'Era John S. McGrath Jonathan L. Wright Andrew C. Thorpe Todd M. Morgan Jeffrey M. Holzbeierlein Trinity J. Bivalacqua Srikala S. Sridhar Scott North Daniel A. Barocas Yair Lotan Andrew J. Stephenson Bas W. van Rhijn Philippe E. Spiess Siamak Daneshmand Shahrokh F. Shariat 《BJU international》2021,127(5):528-537
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Lillian M. Smyth Kelsey R. Monson Komal Jhaveri Alexander Drilon Bob T. Li Wassim Abida Gopa Iyer John F. Gerecitano Mrinal Gounder James J. Harding Martin H. Voss Vicky Makker Alan L. Ho Pedram Razavi Alexia Iasonos Philip Bialer Mario E. Lacouture Jerrold B. Teitcher Joseph P. Erinjeri Nora Katabi Matthew G. Fury David M. Hyman 《Investigational new drugs》2017,35(6):742-750
138.
Mariem Smaoui-Jardak Walid Kriaa Mohamed Maalej Mohamed Zouari Lotfi Kamoun Wassim Trabelsi Ferjani Ben Abdallah Nada Elloumi 《Ecotoxicology (London, England)》2017,26(8):1089-1104
The objective of this study was to investigate the effects of phosphogypsum (PG) amendment on the physiochemical proprieties of saline and agricultural soils along with the growth, productivity and antioxidant enzyme activities of tomato plants ( Solanum lycopersicum L.) grown on the amended soils under controlled conditions. Obtained results showed that the amendment of saline soil (H) by PG induced a decrease in pH as well as in electrical conductivity. However, for the non saline soil (MC), there was a decrease in pH associated with an increase in electrical conductivity. For both soils, PG amendment led to an increase in Calcium (Ca) and sodium (Na), and a decrease in potassium (K) in plant tissues. Cadmium (Cd), Zinc (Zn) and Chromium (Cr) contents in different parts of plants increased in proportion with PG concentration in the soils. Apart from Cd, all the analyzed metals in tomato fruit were found to be below the recommended maximum allowable concentration (MAC). Our results showed that PG application, at doses not exceeding 20%, seems to be beneficial for growth, photosynthetic activity and productivity of tomato plants as well as in decreasing salinity of saline soils. In these conditions, the use of PG could be a promising project for the rehabilitation of marginalized and saline ecosystems with either ornamental or non-fruit species. For both soils, a significant accumulation of MDA in shoots was detected, reflecting cell membrane damage especially when the PG amendment reached 20%. Beyond 20 and 40% PG, tomato plants developed an enzymatic antioxidant defense system in response to salinity and heavy metal stress. However, at 80% PG, enzymes activities were significantly inhibited. 相似文献
139.
Wassim M. Haddad Vijaysekhar Chellaboina Behnood Gholami 《Optimal control applications & methods.》2009,30(1):27-45
Linear matrix inequalities (LMIs) provide a powerful design framework for linear control problems. In this paper, we use LMIs to develop ??2 (sub)optimal estimators and controllers for nonnegative dynamical systems. Specifically, we formulate a series of generalized eigenvalue problems subject to a set of LMI constraints for designing ??2 suboptimal estimators, static controllers, and dynamic controllers for nonnegative dynamical systems. The resulting ??2 suboptimal controllers guarantee that the closed‐loop plant system states remain in the nonnegative orthant of the state space. Finally, a numerical example is provided to demonstrate the efficacy of the proposed approach. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
140.
Wassim Elyaman Elizabeth M. Bradshaw Catherine Uyttenhove Valérie Dardalhon Amit Awasthi Jaime Imitola Estelle Bettelli Mohamed Oukka Jacques van Snick Jean-Christophe Renauld Vijay K. Kuchroo Samia J. Khoury 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(31):12885-12890
The development of T helper (TH)17 and regulatory T (Treg) cells is reciprocally regulated by cytokines. Transforming growth factor (TGF)-β alone induces FoxP3+ Treg cells, but together with IL-6 or IL-21 induces TH17 cells. Here we demonstrate that IL-9 is a key molecule that affects differentiation of TH17 cells and Treg function. IL-9 predominantly produced by TH17 cells, synergizes with TGF-β1 to differentiate naïve CD4+ T cells into TH17 cells, while IL-9 secretion by TH17 cells is regulated by IL-23. Interestingly, IL-9 enhances the suppressive functions of FoxP3+ CD4+ Treg cells in vitro, and absence of IL-9 signaling weakens the suppressive activity of nTregs in vivo, leading to an increase in effector cells and worsening of experimental autoimmune encephalomyelitis. The mechanism of IL-9 effects on TH17 and Tregs is through activation of STAT3 and STAT5 signaling. Our findings highlight a role of IL-9 as a regulator of pathogenic versus protective mechanisms of immune responses. 相似文献