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101.
Long BR Michaelsson J Loo CP Ballan WM Vu BA Hecht FM Lanier LL Chapman JM Nixon DF 《Clinical and Vaccine Immunology : CVI》2008,15(1):120-130
Recent studies indicate that innate immunity in influenza virus infection is an area of substantial importance for our understanding of influenza virus pathogenesis, yet our knowledge of the mechanisms controlling innate immunity remains limited. Further delineation of the roles of NK cells and innate immunity in viral infection may have important implications for the development of improved influenza virus vaccines. In this study, we evaluated the phenotype and function of NK and T lymphocytes, as well as influenza virus-specific immunoglobulin G production, prior to and following vaccination with the routinely administered trivalent influenza virus vaccine. We demonstrate influenza virus antigen-specific innate and adaptive cellular responses and evaluate changes in NK cell receptor expression over time. Our results demonstrate increased innate and adaptive cellular immune responses and show that NK cells are a significant source of gamma interferon (IFN-γ) following influenza virus vaccination. An increase in the frequency of IFN-γ-producing NK cells was observed in many subjects postvaccination. The subset distribution with respect to CD56dim and CD56bright NK cell subsets remained stable, as did the NK cell phenotype with respect to expression of cell surface activating and inhibitory receptors. These results may form the basis for further investigations of the role of NK cells in immunity to influenza. 相似文献
102.
Mahdi N Al-Ola K Al-Subaie AM Ali ME Al-Irhayim Z Al-Irhayim AQ Almawi WY 《Clinical and Vaccine Immunology : CVI》2008,15(4):729-731
We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk. 相似文献
103.
Stayoussef M Al-Jenaidi FA Al-Abbasi A Al-Ola K Khayyat H Mahjoub T Almawi WY 《Clinical and Vaccine Immunology : CVI》2008,15(2):379-381
Tumor necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified. 相似文献
104.
Ines Dallel Intidhar Ben Salem Abderrahmen Merghni Wassim Bellalah Fadoua Neffati Samir Tobji Maha Mastouri Adel Ben Amor 《The Angle orthodontist》2020,90(4):532
ObjectivesTo evaluate the effect of orthodontic appliances on physicochemical, biochemical, and oxidative stress changes in salivary parameters during treatment.Materials and MethodsA cohort study was conducted with 112 healthy patients. Salivary samples were taken at baseline, 1 month, and 9 months after placement of the orthodontic appliances used in treatment.ResultsA statistically significant difference was observed in certain examined salivary parameters, including enzymes, electrolytes, and oxidative stress markers.ConclusionsThe use of aligners had a lower prevalence of disturbing salivary parameters. Orthodontist must consider these changes to prevent the occurrence of white spot lesions. 相似文献
105.
106.
Nunzia Cinzia Paladino Carole Guérin Aoïfe Lowery Andrea Attard Wassim Essamet Eveline Slotema Isabelle Morange Frédéric Castinetti Thierry Brue Anderson Loundou David Taïeb Frédéric Sebag 《Surgical oncology》2018,27(2):231-235
Background
adrenal tumor-to-liver uptake value (Tmx:Lmx) on 18F-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses. The potential impact of steroid hormone secretion on 18F-FDG uptake is still debatable. The aim of this study was to evaluate this relationship.Methods
2010–2015: 73 patients who underwent adrenalectomy for adrenocortical tumors [49 secreting/(SA) and 24 non-secreting/(NSA)] were retrospectively included in the study. Fourteen were malignant. All patients underwent hormonal evaluation, functional and anatomical imaging, Weiss scoring and Ki 67 evaluation.Results
malignant tumors exhibit higher SUVmax than benign tumors (median 7.75 vs 3.06 respectively, p?<?0.001) and Tmx:Lmx was 2.7 vs 1.17 for benign tumors, p?<?0.001.Tmx:Lmx was positively correlated to Weiss score (p?<?0.001).No significant difference was observed for Tmx:Lmx between SA and NSA overall (p?=?0.851), regardless of the subgroup of tumors analyzed. Tmx:Lmx was not correlated to tumor size (p?<?0.508) or 24?h free urinary cortisol level (p?<?0.522).Conclusions
no correlation was observed between Tmx:Lmx and hormonal status, however the correlation between ratio, malignancy and Weiss score confirm the utility of 18F-FDG PET/CT for the differentiation of benign from malignant adrenal lesions, irrespective of the hormone secretory status of the tumor. 18F-FDG PET/CT is a useful biomarker in the diagnosis of adrenal tumors, regardless of the secretion status. 相似文献107.
Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey‐Holden Prostate Cancer Academy Meeting
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108.
Late outcomes of adult survivors of childhood non‐Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study
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Matthew J. Ehrhardt John T. Sandlund Nan Zhang Wei Liu Kirsten K. Ness Nickhill Bhakta Wassim Chemaitilly Kevin R. Krull Tara M. Brinkman Deborah B. Crom Larry Kun Sue C. Kaste Gregory T. Armstrong Daniel M. Green Kumar Srivastava Leslie L. Robison Melissa M. Hudson Daniel A. Mulrooney 《Pediatric blood & cancer》2017,64(6)
109.
110.