全文获取类型
收费全文 | 1452篇 |
免费 | 80篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 119篇 |
妇产科学 | 27篇 |
基础医学 | 159篇 |
口腔科学 | 29篇 |
临床医学 | 90篇 |
内科学 | 237篇 |
皮肤病学 | 36篇 |
神经病学 | 79篇 |
特种医学 | 107篇 |
外科学 | 196篇 |
综合类 | 35篇 |
预防医学 | 67篇 |
眼科学 | 29篇 |
药学 | 142篇 |
中国医学 | 4篇 |
肿瘤学 | 178篇 |
出版年
2023年 | 6篇 |
2022年 | 18篇 |
2021年 | 45篇 |
2020年 | 23篇 |
2019年 | 30篇 |
2018年 | 49篇 |
2017年 | 36篇 |
2016年 | 35篇 |
2015年 | 47篇 |
2014年 | 61篇 |
2013年 | 68篇 |
2012年 | 128篇 |
2011年 | 137篇 |
2010年 | 76篇 |
2009年 | 52篇 |
2008年 | 80篇 |
2007年 | 76篇 |
2006年 | 57篇 |
2005年 | 57篇 |
2004年 | 69篇 |
2003年 | 42篇 |
2002年 | 43篇 |
2001年 | 17篇 |
2000年 | 18篇 |
1999年 | 15篇 |
1998年 | 8篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 5篇 |
1992年 | 19篇 |
1991年 | 13篇 |
1990年 | 16篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 13篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1979年 | 5篇 |
1977年 | 7篇 |
1975年 | 7篇 |
1974年 | 8篇 |
1973年 | 6篇 |
1972年 | 10篇 |
1971年 | 8篇 |
1970年 | 4篇 |
1969年 | 6篇 |
1968年 | 7篇 |
1967年 | 4篇 |
排序方式: 共有1537条查询结果,搜索用时 15 毫秒
991.
Background and Objectives:
Allergic Rhinitis is rather erroneously viewed as a trivial disease. It is important in that it can significantly affect quality of life. There is paucity of community based prevalence studies on the disease in India. This study was planned to assess the prevalence of allergic rhinitis in adults, the proportion of asthmatics among them, risk factors associated and treatment seeking behaviour among the patients.Materials and Methods:
A community based cross sectional study was conducted in Mehrauli, South Delhi among 1200 adults, aged 30 years and over selected by systematic random sampling from two randomly selected wards. A pre-tested questionnaire was used to collect information regarding symptoms, risk factors and treatment seeking behaviour. Allergic Rhinitis was diagnosed as per ARIA guidelines. Spirometry was done to diagnose asthma among them. Multivariate logistic regression analysis was done to find the association of risk factors with disease.Results:
The prevalence of Allergic Rhinitis was found to be 11% (132 subjects) and 33.3% (44 patients) among them also had asthma. Overcrowding (aOR = 6.4), absence of cross-ventilation (aOR = 2.5), occupational exposure to dust/smoke (aOR = 2.1), tobacco smoking (aOR = 2.1), family history of allergic diseases (aOR = 2.7) and clinical allergy (aOR = 10.2) were found to be independent risk factors associated with Rhinitis. More patients of Rhinitis with asthma (75%) took treatment, relative to those without asthma (40%) who, mostly relied on home remedies (42%) or, did not seek any treatment (18%) (P = 0.031).Interpretations and Conclusion:
The burden of Allergic Rhinitis is high with a considerable overlap with asthma. These allergic diseases and emphasize the importance of early and regular treatment.KEY WORDS: Allergic Rhinitis, prevalence, risk factors, treatment seeking behaviour 相似文献992.
Two patients who were placed on a low-iodine diet in preparation for testing and possible treatment with radio-iodine developed severe hyponatremia that required hospitalization. In elderly patients or those with risk factors for hyponatremia, serum sodium should be measured. 相似文献
993.
Mineralocorticoid Receptor Antagonist Pretreatment to MINIMISE Reperfusion Injury After ST‐Elevation Myocardial Infarction (The MINIMISE STEMI Trial): Rationale and Study Design
下载免费PDF全文
![点击此处可从《Clinical cardiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Heerajnarain Bulluck MBBS Georg M. Fröhlich MD Shah Mohdnazri MBBS Reto A. Gamma FRCP John R. Davies PhD Gerald J. Clesham MD Jeremy W. Sayer MD Rajesh K. Aggarwal MD Kare H. Tang FRCP Paul A. Kelly MD Rohan Jagathesan MD Alamgir Kabir PhD Nicholas M. Robinson MD Alex Sirker PhD Anthony Mathur PhD Daniel J. Blackman MD Cono Ariti MSc Arvindra Krishnamurthy MBBS Steven K. White MBBS Pascal Meier MD James C. Moon MD John P. Greenwood PhD Derek J. Hausenloy MDPhD 《Clinical cardiology》2015,38(5):259-266
Novel therapies capable of reducing myocardial infarct (MI) size when administered prior to reperfusion are required to prevent the onset of heart failure in ST‐segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). Experimental animal studies have demonstrated that mineralocorticoid receptor antagonist (MRA) therapy administered prior to reperfusion can reduce MI size, and MRA therapy prevents adverse left ventricular (LV) remodeling in post‐MI patients with LV impairment. With these 2 benefits in mind, we hypothesize that initiating MRA therapy prior to PPCI, followed by 3 months of oral MRA therapy, will reduce MI size and prevent adverse LV remodeling in STEMI patients. The MINIMISE‐STEMI trial is a prospective, randomized, double‐blind, placebo‐controlled trial that will recruit 150 STEMI patients from four centers in the United Kingdom. Patients will be randomized to receive either an intravenous bolus of MRA therapy (potassium canrenoate 200 mg) or matching placebo prior to PPCI, followed by oral spironolactone 50 mg once daily or matching placebo for 3 months. A cardiac magnetic resonance imaging scan will be performed within 1 week of PPCI and repeated at 3 months to assess MI size and LV remodeling. Enzymatic MI size will be estimated by the 48‐hour area‐under‐the‐curve serum cardiac enzymes. The primary endpoint of the study will be MI size on the 3‐month cardiac magnetic resonance imaging scan. The MINIMISE STEMI trial will investigate whether early MRA therapy, initiated prior to reperfusion, can reduce MI size and prevent adverse post‐MI LV remodeling. 相似文献
994.
Ashish Sharma Vinay Goyal Madhuri Behari Achal Srivastva Garima Shukla Deepti Vibha 《Annals of Indian Academy of Neurology》2015,18(1):49-59
Background:There is limited data on the prevalence of impulse control disorder and related behaviors (ICD-RBs) in Indian patients with Parkinson''s Disease (PD). In the context of potential genetic and environmental factors affecting the expression of ICD-RBs, studying other multiethnic populations may bring in-sights into the mechanisms of these disorders.Objectives:To ascertain point prevalence estimate of ICD-RBs in Indian PD patients, using the validated “Questionnaire for Impulsive-Compulsive Disorders in Parkinson''s disease (QUIP)” and to examine their association with Dopamine replacement therapy (DRT).Results:Total of 299 patients participated in the study. At least one ICD-RB was present in 128 (42.8%), at least one Impulse control disorder (ICD) was present in 74 (24.75%) and at least one Impulse control related compulsive behaviour (ICRB) was present in 93 (31.1%) patients. Punding was the most frequent (12.4%) followed by hyper sexuality (11.04%), compulsive hobbyism (9.4%), compulsive shopping (8.4%), compulsive medication use (7.7%), compulsive eating (5.35%), walkabout (4%) and pathological gambling (3.3%). ≥ 2 ICD-RBs were observed in 15.7% of patients. After multivariate analysis, younger age of onset, being unmarried were specifically associated with presence of ICD. Longer disease duration was specifically associated with presence of ICRB. Whereas smoking and higher dopamine levodopa equivalent daily doses (DA LEDD) were associated with both presence of ICD and ICRB. Higher LD LEDD was specifically associated with presence of ICD-RB.Conclusions:Our study revealed a relatively higher frequency of ICD-RBs, probably because of the use of screening instrument and because we combined both ICDs and ICRBs. Also high proportion of DA use (81.6%) among our patients might be responsible. The role of genetic factors that might increase the risk of developing ICD-RBs in this population needs further exploration. 相似文献
995.
Navdeep Kaur Aman Mahajan Viplove Bhullar Davinder Paul Singh Vibha Saxena A. K. Debnath D. K. Aswal Devarani Devi Fouran Singh Sundeep Chopra 《RSC advances》2019,9(35):20375
Plasmonic dye-sensitized solar cells containing metal nanoparticles suffer from stability issues due to their miscibility with liquid iodine-based electrolytes. To resolve the stability issue, herein, an ion implantation technique was explored to implant metal nanoparticles inside TiO2, which protected these nanoparticles with a thin coverage of TiO2 melt and maintained the localized surface plasmon resonance oscillations of the metal nanoparticles to efficiently enhance their light absorption and make them corrosion resistant. Herein, Au nanoparticles were implanted into the TiO2 matrix up to the penetration depth of 22 nm, and their influence on the structural and optical properties of TiO2 was studied. Moreover, plasmonic dye-sensitized solar cells were fabricated using N719 dye-loaded Au-implanted TiO2 photoanodes, and their power conversion efficiency was found to be 44.7% higher than that of the unimplanted TiO2-based dye-sensitized solar cells due to the enhanced light absorption of the dye molecules in the vicinity of the localized surface plasmon resonance of Au as well as the efficient electron charge transport at the TiO2@Au@N719/electrolyte interface.Ion implantation technique can resolve the stability issue of metal nanoparticles with liquid iodine-based electrolyte to improve PCE of plasmonic dye-sensitized solar cells. 相似文献
996.
Adrenocortical function in patients with pulmonary tuberculosis 总被引:1,自引:0,他引:1
G R Sarma C Immanuel G Ramachandran P V Krishnamurthy V Kumaraswami R Prabhakar 《Tubercle》1990,71(4):277-282
Adrenocortical function was studied in patients with pulmonary tuberculosis and the findings compared with those in healthy subjects. Plasma cortisol levels in newly diagnosed patients were appreciably higher than in the healthy subjects (P less than 0.001). A normal (positive) response to ACTH (tetracosactrin) stimulation was observed in 35 (97%) of 36 healthy subjects, 15 (56%) of 27 newly diagnosed patients with tuberculosis and 5 (42%) of 12 chronic cases (i.e. those who had had the disease for more than 3 years); the difference between the healthy subjects and the two groups of tuberculosis patients was highly significant (P less than 0.001). Dexamethasone caused an appreciable decrease in the plasma cortisol levels of tuberculosis patients. Considering the diurnal variation of cortisol secretion, there was a steady decline in the cortisol levels between 08:00 and 20:00 in the healthy subjects (P = 0.02); in the tuberculosis patients, however, there was a decrease up to 16:00 followed by a significant increase (P = 0.05), and the mean value at 20:00 was similar to that at 08:00. 相似文献
997.
Kroger A Pannikar V Htoon MT Jamesh A Katoch K Krishnamurthy P Ramalingam K Jianping S Jadhav V Gupte MD Manickam P 《Tropical medicine & international health : TM & IH》2008,13(5):594-602
Objective To describe the rationale, design and preliminary results of an open trial of 6 months uniform multi‐drug therapy (U‐MDT) for all types of leprosy patients assuming a cumulative relapse rate not exceeding 5% over 5 years of follow‐up. Methods We intended to recruit 2500 patients each in multi‐bacillary (MB) and pauci‐bacillary (PB) groups from India (five centres) and China (two centres). Standardized clinical criteria were used to assess skin lesions in the field. Results A total of 2912 patients enrolled from November 2003 to May 2007 (India, 2746; China, 166). MB patients constituted 39% and 3% had grade 2 disability. During follow‐up, 27 patients (0.9%) developed new lesions. Of these, 78% were on account of reactions. Six patients had clinically confirmed relapse. Clofazimine‐related skin pigmentation was short‐lived and was acceptable to patients. We analysed data for clinical status of skin lesions. About 2.9% of patients were lost to follow‐up; 85.9% completed treatment, of whom 19% had inactive skin lesions. PB patients responded better than MB patients (27%vs. 6%; P < 0.001). At the end of the first (n = 2013) and second year (n = 807) of follow‐up post‐U‐MDT, in 49% and 46% patients, lesions were inactive, respectively (59% and 57% in PB, 37% and 28% in MB; P < 0.001). Conclusion U‐MDT appears to be promising with respect to clinical status of skin lesions. 相似文献
998.
P Gurumurthy M S Krishnamurthy O Nazareth R Parthasarathy G R Sarma P R Somasundaram S P Tripathy G A Ellard 《The American review of respiratory disease》1984,129(1):58-61
The results are presented of a retrospective analysis of the incidence of jaundice among 3,000 patients with pulmonary tuberculosis and of the activities of serum aspartate aminotransferase among 850 according to their isoniazid acetylator phenotype. The patients had been treated with a variety of isoniazid-containing regimens in a series of controlled clinical trials in South India. The results show that rapid acetylators are no more prone to develop isoniazid-induced hepatic toxicity than are slow acetylators. 相似文献
999.
Anuthama Krishnamurthy Herald J. Sherlin Karthikeyan Ramalingam Anuja Natesan Priya Premkumar Pratibha Ramani Thiruvengadam Chandrasekar 《Head and neck pathology》2009,3(2):153-158
Glandular odontogenic cyst (GOC) is an uncommon jaw bone cyst of odontogenic origin described in 1987 by Gardner et al. It
is a cyst having an unpredictable and potentially aggressive behaviour. It also has the propensity to grow to a large size
and tendency to recur with only 111 cases having been reported thus far. The first case occurred in a 42-year-old female and
presented as a localized swelling extending from 19 to 29 regions. There was a history of traumatic injury at the site. There
was evidence of bicortical expansion and radiographs revealed a multilocular radiolucency. The second case occurred in a 21-year-old
male, as a large swelling in the mandible and radiograph revealed radiolucency in the region. On histopathological examination,
these lesions were diagnosed as GOC. It was concluded that, two cases submitted by us correlate with the existing literature
that GOC’s affect more commonly in the middle age group, having predilection for mandible and that trauma could be a precipitating
factor for its occurrence. The increased recurrence rates can be due to its intrinsic biological behavior, multilocularity
of the cyst, and incomplete removal of the lining following conservative treatment. 相似文献
1000.
Seeking a solution to bring down the prevalence of simple plantar ulcers in the field, Damien Foundation India Trust (DFIT), Chennai, developed a curriculum to teach the field staff of all its projects. The purpose was to make patients self-reliant in the care of their plantar ulcers in their homes. The strategy used was to make patients take care of their ulcers using tools found in their homes and surroundings and become responsible for the care of their limbs. This strategy was implemented in eight projects of DFIT and the programme was followed regularly for one year. Regular monitoring and evaluation showed that under this strategy the prevalence of plantar ulcers was reduced by about 50%. 相似文献