Effect of selective monoamine oxidase inhibitors on the morphine-induced hypothermia in restrained rats

Morphine (30 mg/kg i.p.) produced a hypothermic effect in restrained rats which was antagonized by naloxone pretreatment (10 mg/kg s.c.). This hypothermia was inhibited by deprenyl pretreatment (5 mg/kg i.p.) and by beta-phenylethylamine treatment (25 mg/kg i.p.). However, the effect of morphine was partially potentiated when a higher dose of deprenyl (10 mg/kg i.p.) was administered. Pretreatment with clorgyline (1 mg/kg i.p.) potentiated the morphine-induced hypothermia. In contrast, the effect of morphine was antagonized when a higher dose of clorgyline was used (5 mg/kg i.p.). Based on these results, a possible role of brain serotonin and dopamine in the thermoregulatory effects of morphine is proposed in this paper.     

脑得生提取物对动物心血管、呼吸及中枢神经系统影响的研究

目的：探讨脑得生提取物的安全性。方法：观察脑得生提取物对清醒脚犬心电图、血压、呼吸和小鼠一般行为、神经系统和运动协调功能的影响。结果：脑得生提取物在1．5～15g／kg给药剂量,对清醒Beagle犬的收缩压、舒张压、呼吸频率以及心电图指标无明显影响。脑得生提取物在10～30g／kg给药剂量,对清醒小鼠的一般行为和运动协调功能没有明显影响;100g／kg给药剂量对小鼠的翻正反射和爬杆试验有一定影响,在给药后2小时完全恢复。结论：脑得生提取物对动物心血管系统、呼吸系统及中枢神经系统均无明显影响。     

牛大力的化学成分研究

目的 研究牛大力Millettia speciosa的化学成分.方法 应用多种色谱技术对牛大力进行分离纯化,并通过光谱方法鉴定化合物的结构. 结果从牛大力乙醇提取物的醋酸乙酯部位中分离得到13个化合物,分别鉴定为(-)-高丽槐素(Ⅰ)、芒柄花素(Ⅱ)、3,4,2',4'-四羟基查尔酮(Ⅲ)、圆齿火棘酸(pyracrenic acid,Ⅳ)、(-)-丁香脂素(Ⅴ)、dihydrodehydrodiconiferyl alcohol(Ⅵ)、5-羟甲基糠醛(Ⅶ)、α-甲氧基-2,5-呋喃二甲醇(Ⅷ)、2,5-二羟基苯甲酸(Ⅸ)、豆甾醇(Ⅹ)、豆甾醇-3-O-β-D-葡萄糖苷(Ⅺ)、β-谷甾醇(Ⅻ)及胡萝卜苷(ⅩⅢ).结论 化合物Ⅱ～ⅩⅢ均为首次从该植物中分离得到.     

GC-MS分析四数九里香的挥发油成分

目的 研究四数九里香挥发油的成分.方法 采用GC-MS法分析四数九里香的挥发油成分.结果与结论 从四数九里香挥发油中分离出38个组分,确认了其中的37种,主要成分为薄荷酮(53%)、异薄荷酮(14.45%)、柠檬烯(13.21%)和胡椒酮(7.96%),其中15个成分为首次从四数九里香中分离得到.     

心电图正常的急性肾功能衰竭患者心肌酶的意义

目的:探讨血清心肌酶在心电图(ECG)正常的急性肾功能衰竭(ARF)患者中的意义。方法:选择ECG正常的ARF患者及正常健康成人各30例,测定其血清心肌酶．比较ARF患者及正常健康人血清心肌酶。结果:ARF组血清CK、LDH活性均高于对照组(P＜0．01)。结论:ARF患者当ECG正常时血清心肌酶已经升高,血清心肌酶的测定能早期发现ARF时的心肌损害。     

Results of the national survey of borderline ovarian tumors in Spain

MATERIAL AND METHODS: Retrospective multi-center analysis of women diagnosed with borderline ovarian tumor and treated between January 1990 and December 1997. A national survey was conducted, in which 457 patients from 27 centers corresponding to ten of Spain's autonomous communities were analyzed. RESULTS: Four hundred fifty-seven women with borderline ovarian tumor were analyzed. The mean age of patients was 45.5+/-16.9 years. Of these, 390 patients (85.3%) were at stage I, 8 (1.8%) were at stage II and 36 (7.9%) at stage III. A bilateral tumor was observed in 63 women (13.8%). The mean tumor size was 14.2 cm and in 88 cases (19.3%) the tumor was on the surface of the ovary. Microinvasion was observed in 25 (5.5%) cases, and 29 women (6.3%) showed a micropapillary pattern. Study of the factors related to the appearance of peritoneal implants revealed positive tumor markers (OR 15.02: 1.9-32.9) and a tumor on the ovarian surface (OR 8.0: 1.8-127) to be independent risk factors. With respect to recurrence, the presence of peritoneal implants at the time of initial surgery (OR 3.4: 1.1-10.4) and signs of microinvasion in the anatomicopathological study (OR 5.5: 1.5-17.8) were found to be independent risk factors. The overall survival rate in our series was 97% with a mean follow-up of 88.3 months. The survival rate by stage was 97% for stage I, 100% for stage II and 97% for stage III. CONCLUSIONS: Although borderline ovarian tumors have an excellent prognosis, they are not exempt from a risk of recurrence. Characterization of patients with borderline ovarian tumor is essential in order to prevent their evolution. Likewise, the taking on board of risk factors will enable more selective treatments to be offered in each case.     

原发性精囊癌的诊断和治疗(附4例报告)

目的 探讨原发性精囊癌的临床表现、诊断及治疗.方法 回顾性分析4例原发性精囊癌患者的临床症状、体征、检查结果、手术方案及术后治疗.1例行双侧精囊连同膀胱、前列腺、直肠根治性切除术.2例行精囊、部分膀胱、前列腺切除术.1例行精囊、膀胱、前列腺、输尿管下段、直肠前壁切除术及回肠膀胱术.结果 2例患者术后随访5年未见复发与转移,1例术后2年死于结肠癌,1例术后随访3个月未见复发与转移.结论 原发性精囊癌的临床表现为血精或血尿,下尿路梗阻症状,大便性状与次数的改变,早期症状不明显,患者血清中前列腺特异抗原(PSA)、CEA阴性,细胞角蛋白(CK)阳性.治疗主要根据肿瘤侵及的范围采取相应的手术方式予以切除,术后应加以联合化疗.     

苏州地区2009年-2010年新型甲型H1N1流感流行特征及动态分析

目的:为了解本市甲型H1N1流感暴发的流行趋势,更好地做好甲型H1N的防控工作提供依据。方法:采用实时荧光PCR对本市流感监测哨点的标本和疑似甲型H1N1流感患者的咽拭子样品进行检测。结果:这次甲型H1N1流感暴发的高峰期在11月和12月,阳性率分别51.06%和42.11%。青少年在感染者中比例较高(37.19%)。结论:这次甲型H1N1流感的流行特征是集中在10到12月三个月,暴发还是聚集在学生中,所以在以后的防控工作中要以学生为主。