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51.
The WFSBP Task Force on Eating Disorders 《The world journal of biological psychiatry》2013,14(6):400-443
AbstractObjectives. The treatment of eating disorders is a complex process that relies not only on the use of psychotropic drugs but should include also nutritional counselling, psychotherapy and the treatment of the medical complications, where they are present. In this review recommendations for the pharmacological treatment of eating disorders (anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED)) are presented, based on the available literature. Methods. The guidelines for the pharmacological treatment of eating disorders are based on studies published between 1977 and 2010. A search of the literature included: anorexia nervosa bulimia nervosa, eating disorder and binge eating disorder. Many compounds have been studied in the therapy of eating disorders (AN: antidepressants (TCA, SSRIs), antipsychotics, antihistaminics, prokinetic agents, zinc, Lithium, naltrexone, human growth hormone, cannabis, clonidine and tube feeding; BN: antidepressants (TCA, SSRIs, RIMA, NRI, other AD), antiepileptics, odansetron, d-fenfluramine Lithium, naltrexone, methylphenidate and light therapy; BED: antidepressants (TCA, SSRIs, SNRIs, NRI), antiepileptics, baclofen, orlistat, d-fenfluramine, naltrexone). Results. In AN 20 randomized controlled trials (RCT) could be identified. For zinc supplementation there is a grade B evidence for AN. For olanzapine there is a category grade B evidence for weight gain. For the other atypical antipsychotics there is grade C evidence. In BN 36 RCT could be identified. For tricyclic antidepressants a grade A evidence exists with a moderate-risk-benefit ratio. For fluoxetine a category grade A evidence exists with a good risk-benefit ratio. For topiramate a grade 2 recommendation can be made. In BED 26 RCT could be identified. For the SSRI sertraline and the antiepileptic topiramate a grade A evidence exists, with different recommendation grades. Conclusions. Additional research is needed for the improvement of the treatment of eating disorders. Especially for anorexia nervosa there is a need for further pharmacological treatment strategies. 相似文献
52.
Bossi P Tegnell A Baka A Van Loock F Hendriks J Werner A Maidhof H Gouvras G;Task Force on Biological Chemical Agent Threats Public Health Directorate European Commission Luxembourg 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2004,9(12):E15-E16
Interest in Brucella species as a biological weapon stems from the fact that airborne transmission of the agent is possible. It is highly contagious and enters through mucous membranes such as the conjunctiva, oropharynx, respiratory tract and skin abrasions. It has been estimated that 10-100 organisms only are sufficient to constitute an infectious aerosol dose for humans. Signs and symptoms are similar in patients whatever the route of transmission and are mostly non-specific. Symptoms of patients infected by aerosol are indistinguishable from those of patients infected by other routes. Regimens containing doxycycline plus streptomycin or doxycycline plus rifampin are effective for most forms of brucellosis. Isolation of patients is not necessary. Trimethoprim-sulfamethoxazole and fluoroquinolones also have good results against Brucella, but are associated with high relapse rates when used as monotherapy. The combination of ofloxacin plus rifampicin is associated with good results. Even if there is little evidence to support its utility for post-exposure prophylaxis, doxycycline plus rifampicin is recommended for 3 to 6 weeks. 相似文献
53.
茶树籽对钉螺生殖腺和肝脏的影响 总被引:8,自引:0,他引:8
目的 :了解钉螺组织经茶树籽处理的影响。方法 :应用电镜技术观察处理后的钉螺肝脏及生殖腺组织的超微结构。结果 :钉螺在茶树籽作用 2 4 h后 ,肝内细胞受损。雄性生殖细胞有凝固性及溶解性变化 ;成熟精子细胞膜肿胀与内部结构分离 ,线粒体鞘呈现凝集型 ,支持细胞可见凝固性改变 ,且彼此断裂并与生殖细胞分离。雌性钉螺生殖腺可见卵细胞肿胀 ,严重时滤泡细胞有破裂 ,卵细胞膜则可丧失完整性。结论 :茶树籽能损伤钉螺的生殖腺和肝脏。 相似文献
54.
55.
DNA探针用于中华按蚊和嗜人按蚊的分类研究 总被引:11,自引:1,他引:11
本项研究首次报道了我国中华按蚊和嗜人按蚊DNA基因库的建立,并从中华按蚊DNA基因库中筛选出一特异的DNA片段,以此为DNA探针,分别与中华按蚊DNA和嗜人按蚊DNA进行斑点杂交试验,其结果证明该DNA探针可与任何发育期的中华按蚊DNA杂交而不与嗜人按蚊DNA杂交,该探针敏感性高,可检测出7.5ng的中华按蚊DNA,大约相当于1个蚊虫总DNA的1/150,可用于区别中华按蚊和嗜人按蚊。 相似文献
56.
Church J Lowry A Simmang C;Standards Task Force;American Society of Colon Rectal Surgeons 《Diseases of the colon and rectum》2001,44(10):1404-1412
It should be recognized that these guidelines should not be deemed inclusive of all proper methods of care or exclusive of methods of care reasonably directed to obtaining the same results. The ultimate judgment regarding the propriety of any specific procedure must be made by the physician in light of all of the circumstances presented by the individual patient.
Prepared By The Standards Task Force The American Society of Colon and Rectal Surgeons 相似文献
57.
日本血吸虫大陆株副肌球蛋白部分基因克隆 总被引:2,自引:0,他引:2
目的 :克隆日本血吸虫大陆株副肌球蛋白部分基因。方法 :用 PCR方法根据已发表日本血吸虫菲律宾株副肌球蛋白基因部分核苷酸序列扩增大陆株副肌球蛋白基因。结果 :获得一日本血吸虫大陆株 72 0 bp基因克隆。结论 :经核苷酸序列分析证实 ,本克隆基因与菲律宾株基因核苷酸同源性为 99.0 3%。 相似文献
58.
The model of the clinical practice of emergency medicine 总被引:13,自引:0,他引:13
Hockberger RS Binder LS Graber MA Hoffman GL Perina DG Schneider SM Sklar DP Strauss RW Viravec DR Koenig WJ Augustine JJ Burdick WP Henderson WV Lawrence LL Levy DB McCall J Parnell MA Shoji KT;American College of Emergency Physicians Core Content Task Force II 《Annals of emergency medicine》2001,37(6):745-770
59.
阿苯达唑对感染仓鼠的美洲钩虫幼虫及虫卵的作用 总被引:1,自引:0,他引:1
感染美洲钩虫成虫的仓鼠口服阿苯达唑75或150mg/kg的有效率为83.8%和100%。治前3d,2个治疗组每鼠每g粪便培养的幼虫数为29716±3299和28256±118,对照组的为8828±2659。治后3d,治疗组的粪便培养未查见幼虫,而对照组的为9066±7416。此外,受治2组的培养粪便残渣用饱和盐水漂浮虫卵时,无或仅查见几个变性虫卵。仓鼠于感染第3期幼虫后3、7或14d口服1剂阿苯达唑150或300mg/kg时,粪便虫卵阳性率为0-9.1%,减虫率为96.8-100%。 相似文献
60.
实验室和现场试验,溴乙酰胺对中华双腔吸虫和胰阔盘吸虫的第一中间宿主枝小丽螺(Ganesella virgo)具有良好的毒杀作用。现场用0.5和1g/m~2的剂量喷洒,枝小丽螺的死亡率分别为74.7~84.7%和84.8~95.7%。有关该药对家畜和牧草的毒性问题有待进一步试验。 相似文献