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Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India. 相似文献
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W. Siegert G. Hackl U. Löhrs D. Huhn 《Journal of molecular medicine (Berlin, Germany)》1985,63(2):56-61
Summary Between 1978 and 1983 a total of 33 patients with non-Hodgkin's lymphoma (NHL) involving the gastrointestinal tract were seen in our institution. Pathological classification was performed according to Kiel. Low grade NHL was diagnosed in 17, high grade NHL in 16 patients. The most frequent histological entity was lymphoplasmocytoid immunocytoma (11 patients). The most common sites of origin were the stomach (23 patients) and the ileocecal region (6 patients). The majority of patients presented with stage I and II disease (20 of 33 patients). As a rule primary therapy consisted of surgery with curative intent. Most of the patients received additional chemotherapy or radiotherapy. Patients with limited disease and complete tumour resection showed long-term survival from 12+ to 57+ months (mean 32.9+ months). Patients with advanced disease (stage III and IV) and only palliative surgery or with lymphoblastic lymphoma had a probability of survival of less than 12 months.Abbreviations NHL
non-Hodgkin's lymphoma
- IC
lymphoplasmocytoid immunocytoma
- CC
centrocytic lymphoma
- CB/CC
centroblastic/centrocytic lymphoma
- CB
centroblastic lymphoma
- IB
immunoblastic lymphoma
- LB
lymphoblastic lymphoma
- NWDL
nodular well-differentiated lymphocytic lymphoma
- NPDL
nodular poorly differentiated lymphocytic lymphoma
- NM
nodular mixed lymphoma
- NH
nodular histiocytic lymphoma
- DWDL
diffuse well-differentiated lymphocytic lymphoma
- DPDL
diffuse poorly differentiated lymphocytic lymphoma
- DM
diffuse mixed lymphoma
- DH
diffuse histiocytic lymphoma
- DU
diffuse undifferentiated lymphoma
- CT
computerized tomography
- GI
gastrointestinal 相似文献
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