Die Cleistothecium-Bildung von Ctenomyces trichophyticus — Trichophyton gypseum var. asteroides — auf sterilisiertem Heu

Die auf sterilem Heu gebildeten Cleistothecia des Ctenomyces trichophyticus haben sich identisch mit jenen erwiesen, welche sich auf mit Frauenhaar bestreutem Erde-Nährboden entwickelten. Dies wird als Beweis dafür angesehen, daß einerseits das T. gypseum var. asteroides mit dem Ctenomyces trichophyticus identisch ist, andererseits aber ermöglicht dieses Verfahren die Ausarbeitung einer Methode, durch die das zur botanischen Klassifizierung nötige Cleistothecium auch für andere Dermatophyten aufgedeckt werden könnte.     

荧光分光光度法测定甲磺酸培氟沙星胶囊的含量

目的用荧光分光光度法测定甲磺酸培氟沙星胶囊中甲磺酸培氟沙星的含量.方法样品稀释后,以320nm为激发波长,440nm为发射波长,用荧光分光光度法测定其含量.结果甲磺酸培氟沙星在0.5～2.5 μg.ml-1浓度范围呈线性,回归方程为Y=23.86C+2.37,r=0.9999.回收率为99.46%(RSD为0.81%,n=5).结论本法简便易行,灵敏度高,重线性好,可用于甲磺酸培氟沙星胶囊的含量测定.     

环氧酶-2抑制剂的选择性及安全性

目的：了解环氧酶-2抑制剂的作用特点及其临床的用药安全性。方法：综合国内外一些文献资料,阐述环氧酶-2抑制剂的作用方式,作用特点及分类方法,并通过总结临床研究及药物流行病学的研究报道,对临床用药安全性作了初步评价。结果：环氧酶-2抑制剂通过对环氧酶-2的选择性抑制作用,而起到抗炎镇痛作用。而对环氧酶-1的抑制作用较少或甚少,与传统的非甾类抗炎药相比,减少了胃肠道等的毒副作用。提高了用的安全性。结论：环氧酶-2抑制剂特别是高选择性（特异性）抑制剂,由于安全有效,可望成为继传统非甾类抗炎药后的新一代抗炎镇痛药物。     

速激肽受体拮抗剂对白三烯C4引起的豚鼠心血管反应的抑制作用

iv白三烯C₄(LTC₄)0.8nmol·kg^-1引起麻醉豚鼠血压降低和心脏微血管依文思蓝渗出增加。速激肽NK-1受体拮抗剂CP-96345 (2.06μmol·kg^-1,iv)和NK-2受体拮抗剂SR-48968(1.66μmol·kg^-1,iv)部分抑制心房微血管渗漏(分别为46.6%和37.5%);两药合用可明显抑制LTC₄引起的低血压和心房、心室微血管渗漏(分别为58.1%和54.1%),其作用与白三烯特异性拮抗剂ONO-1078(0.06μmol·kg^-1,iv)相似。结果表明速激肽NK-1和NK-2受体可能参与白三烯引起的低血压和心脏炎症反应。     

杏丁注射液对不稳定型心绞痛患者心电图QT的影响

1临床资料符合WHO诊断标准的不稳定型心绞痛(UAP)患者40(男12,女28)例,平均年龄(58.0±8.2)岁.UAP对照组20(男10,女10)例,平均年龄(56.8±9.4)岁.杏丁组常规应用硝酸酯类、肝素、阿司匹林等药物的同时应用杏丁注射液(贵州益佰制药股份有限公司生产,5 mL/支,每支含银杏总黄酮4.5～5.5 mg,双嘧达莫1.8～2.2 mg)25 mL加50 g/L葡萄糖500 mL,每日1次静滴,共14 d.检查12导联心电图3个心动周期以上算得QTd,为消除心率对QTd的影响,再根据Bazzef公式对QTd进行校正,后取其平均值.QT间期的测量为QRS波群开始至T波结束,不包括U波、双向T波时测量其回到等位线的距离.T波低平不易测量则改为测量V2,V3导联的QT及R-R间期(表1).     

Assessment of the hemostatic effectiveness of human platelets treated with aminomethyltrimethyl psoralen and UV A light using a rabbit ear bleeding time technique

The photochemical aminomethyltrimethyl psoralen (AMT), in conjunction with UV A light (UVA), has been shown to inactivate human immunodeficiency virus-1 and model viruses in platelet suspensions under conditions that have only a minimal effect on in vitro platelet properties. A rabbit ear bleeding time technique was used to assess the hemostatic effectiveness of human platelet suspensions treated with AMT/UVA. New Zealand White rabbits were made thrombocytopenic by a combination of irradiation and heterologous antirabbit platelet antiserum. Reticuloendothelial function in these rabbits was suppressed by the intravenous administration of ethyl palmitate. The hemostatic function of 1- and 5-day-old human platelet suspensions (14.5% plasma) that had been treated on day 1 with 40 micrograms/mL AMT and 24 kJ/m2 UVA (1 x UVA) was evaluated by measuring microvascular bleeding times after a standard incision. Comparable bleeding times were observed after infusion with both control and AMT/UVA-treated platelets stored for either 1 or 5 days. With the transfusion of AMT/1 x UVA-treated platelets stored for 5 days, the mean (+/- SD) bleeding time was 156.3 +/- 39.2 seconds (n = 10). With untreated platelets (no AMT/no UVA), stored for 5 days, the mean bleeding time was 189.2 +/- 36.4 seconds (n = 10). Neither AMT nor 1 x UVA treatment alone influenced the observed bleeding times. In contrast, the hemostatic effectiveness of human platelet suspensions was diminished if they were exposed to three times the standard UVA dose (72 kJ/m2) on day 1 and stored for 4 more days, regardless of whether AMT was present, with the mean bleeding time increasing to 442.2 +/- 122.6 seconds (n = 15, AMT present) or 396.0 +/- 45.9 seconds (n = 10, AMT absent). These results are consistent with data obtained from in vitro studies and indicate that virucidal AMT/1 x UVA treatment does not influence platelet hemostatic function. However, the final conditions to achieve these results must be carefully controlled.     

人参二醇皂甙和三醇皂甙对兔纹状体ATP酶的影响

本文报道用体外给药法,观察了PDS和PTS对纹状体ATP酶(Na⁺、K⁺-ATP酶,Ca²⁺-ATP酶及M²⁺-ATP酶)的影响。结果发现PDS和PTS对Na⁺,K⁺-ATP酶都有明显的抑制作用,且随PDS和PTS浓度的高低,其抑制作用增强或减弱;对Ca²⁺-ATP酶,PDS在10^-5g/ml时有激活作用,当浓度增高到10^-3g/mL时则转为抑制,而PTS仅为抑制效应;对于Mg²⁺-ATP酶能被PDS所兴奋,而被PTS所抑制。此结果表明PDS和PTS对中枢神经系统的作用,可能与其影响脑内ATP酶有密切的内在联系。     

老年人肺癌150例

临床资料 1990-01／2004-06住院老年人肺癌150(男102例，女48)例，年龄60～90(平均74．5)岁．有吸烟史102例(68％)，其中30a以上吸烟史73例(48．7％)．咳嗽、咳痰、痰带血105例(70％)．无呼吸系统症状25例(16．7％)，于健康体检时发现．以肺外症状住院20例(13％)，表现为上腔静脉综合征、Homer综合征、声音嘶哑、杵壮指(趾)、高血钙等．胸片：肺癌110例；痰中脱落细胞检查98例，