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41.
Yuri Noda Yuko Nakanishi Ayaka Nishimae Hiroyo Takahashi Chiya Oshiro Hideo Inaji Masaru Yamasaki 《Diagnostic cytopathology》2020,48(7):652-656
Solid basaloid adenoid cystic carcinoma (SB‐AdCC) is a subtype of breast AdCC which shows more aggressive clinical behavior than other subtypes. Fine‐needle aspiration (FNA) cytology is a useful diagnostic tool for breast malignancies. However, most of the diagnostic cytological characteristics of AdCC are not present in SB‐AdCC and cytomorphological studies of this subtype are limited. Here, we evaluated the utility of FNA in the diagnosis of SB‐AdCC of the breast. A search of the pathology archives of our institutions for FNA specimens of histologically confirmed SB‐AdCC between 2012 and 2019 identified four patients with SB‐AdCC of the breast. All patients were female and the average age was 60 years. Cytologically, one case was classified as malignant, two as indeterminate, and one as unsatisfactory. Smears had low to moderate cellularity. All smears showed ribbon‐like material surrounding the clusters and a vertical nuclear arrangement toward the peripheral rim. Hyaline globules appeared only in one case. Cells in all cases showed an oval, angular, and spindle shape hyperchromatic nuclei with mild to severe atypia, and also dispersed naked nuclei similar to the cells of the clusters were detected in one case. In histological sections, these cytological findings were compatible with the histological findings and divergent histological differentiation was detected. Diagnosing of few cellular smears of SB‐AdCC is difficult whereas the features of peripheral rim of the clusters, naked nuclei, and the divergent differentiation may be important for diagnosing SB‐AdCC of the breast. 相似文献
42.
Hiroaki Yoshida Nobuyoshi Oshiro Aoi Fukuda Shoko Gamoh Kimishige Shimizutani Shosuke Morita 《Oral Radiology》2014,30(1):129-133
Masticatory muscle tendon-aponeurosis hyperplasia is a newly defined disease entity in Japan, in which limited mouth opening results from limited masticatory muscle extension caused by hyperplasia of the tendon and aponeurosis. Recently, we encountered a rare case of reformed bilateral coronoid process and mandibular angle after coronoidectomy and anglectomy. A 19-year-old female with gradually progressive trismus had been diagnosed with this disease. Under general anesthesia, she received coronoidotomy of the bilateral coronoid process and anglectomy. At 1 week postoperatively, trismus was improved. At 6 months postoperatively, panoramic imaging showed the initiation of bilateral reformed coronoid process and mandibular angle. At 3 years postoperatively, computed tomography (CT) and three-dimensional reconstructed CT (3D-CT) demonstrated reformed coronoid process and mandibular angle. However, the maximum mouth opening length was not decreased. She continued to perform mandibular condyle movement exercise every day. Panoramic imaging is a very useful examination for evaluating bone reformation after coronoidectomy and anglectomy for masticatory muscle tendon-aponeurosis hyperplasia. In particular, CT and 3D-CT demonstrated reformed coronoid process and mandibular angle. Postoperative mouth-opening training is an important prognostic factor to prevent the recurrence of trismus in this disease. 相似文献
43.
44.
The clinical manifestations of 1,042 Japanese patients with nonpolyposis colorectal cancer who underwent a resection between 1972 and 1992 at the National Kyushu Cancer Center were examined. Hereditary nonpolyposis colorectal cancer (HNPCC) was found in 39 (3.7%) patients. Some characteristic findings in HNPCC cases included early age of onset, a preponderance of right colon cancers, an increased frequency of colorectal cancers, and a favorable survival. Metachronous (postoperative) colorectal cancers developed significantly more often in cases with HNPCC than in those without (12.8% vs. 1.8%, P = 0.0001). Metachronous (postoperative) extracolonic cancers tended to develop more often in cases with HNPCC than in those without (10.2% vs. 3.5%, P = 0.053). In cases with HNPCC, the mean interval between the initial surgery and the diagnosis of the second cancer was 61 months (range; 12–153 months). These findings thus indicate the importance of routine and long-term follow-up to identify any second lesions, especially in patients with HNPCC. © 1996 Wiley-Liss, Inc. 相似文献
45.
Masahiro Ohira Yasuhiro Watanabe Takashi Yamaguchi Hiroki Onda Shuhei Yamaoka Kazuki Abe Shoko Nakamura Sho Tanaka Naoyuki Kawagoe Taiki Nabekura Takashi Oshiro Daiji Nagayama Ichiro Tatsuno Atsuhito Saiki 《Obesity facts》2021,14(6):633
IntroductionLaparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG.MethodsWe retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG.ResultsA significant decrease was observed in the patients'' BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG.Discussion/ConclusionThese results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG. 相似文献
46.
Higuchi Takashi Sugisawa Norihiko Yamamoto Jun Oshiro Hiromichi Han Qinghong Yamamoto Norio Hayashi Katsuhiro Kimura Hiroaki Miwa Shinji Igarashi Kentaro Tan Yuying Kuchipudi Shreya Bouvet Michael Singh Shree Ram Tsuchiya Hiroyuki Hoffman Robert M. 《Cancer chemotherapy and pharmacology》2020,85(2):285-291
Cancer Chemotherapy and Pharmacology - Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of... 相似文献
47.
Takahiro Niimi Tokiko Nakai Keiju Aokage Kenta Tane Tomohiro Miyoshi Joji Samejima Saori Miyazaki Tetsuro Taki Naoya Sakamoto Shingo Sakashita Reiko Watanabe Motohiro Kojima Kenji Suzuki Masahiro Tsuboi Genichiro Ishii 《Cancer science》2022,113(4):1497
Extratumoral lymphatic permeation (ly‐ext) has been reported as an independent poor prognostic factor for lung adenocarcinoma, but whether or not the number of ly‐ext foci is associated with prognosis and its relationship to the immune microenvironment is unclear. We counted the number of ly‐ext foci on pathological slides from patients with completely resected lung adenocarcinoma with ly‐ext, and divided them into two groups: a group with a high number of ly‐ext foci (ly‐ext high) and one with a low number of ly‐ext foci (ly‐ext low). Among the patients with ly‐ext, only a high number of ly‐ext foci was an independent poor prognostic factor. The 3‐year recurrence‐free survival (RFS) rate of the ly‐ext high group was significantly lower than that of the ly‐ext low group (14.7% vs. 50.0%, P < 0.01). Then, we analyzed the immune microenvironment of pT1 lung adenocarcinoma with ly‐ext (13 cases of ly‐ext high and 11 cases of ly‐ext low tumor) by immunohistochemistry using antibodies for stem cell markers (aldehyde dehydrogenase 1 A1 and CD44), tumor‐promoting mucin (MUC1), tumor‐infiltrating lymphocytes (CD4, CD8, FOXP3, and CD79a), and tumor‐associated macrophages (CD204). The number of CD8+ TILs within the primary lesion was significantly lower and the number of FOXP3+ TILs within the primary lesion was significantly higher in the ly‐ext high group (P < 0.05 and P < 0.01, respectively). Our results indicated that a high number of ly‐ext foci was an independent poor prognostic factor. Moreover, tumors with high numbers of ly‐ext foci had a more immunosuppressive microenvironment. 相似文献
48.
Takaaki Konuma Satoshi Takahashi Jun Ooi Akira Tomonari Nobuhiro Tsukada Seiko Kato Aki Sato Fumihiko Monma Senji Kasahara Tokiko Nagamura-Inoue Kaoru Uchimaru Tohru Iseki Arinobu Tojo Takuhiro Yamaguchi Shigetaka Asano 《Annals of hematology》2009,88(6):581-588
Increasing recipient age is a well-known risk factor for graft-versus-host disease (GVHD) and treatment-related mortality
(TRM) and has a negative impact on allogeneic hematopoietic stem cell transplantation. Since the incidence of severe GVHD
after cord blood transplantation (CBT) is lower than that after transplants using bone marrow or mobilized peripheral blood
grafts from adult cells, we should expect better outcomes from CBT in older patients. To evaluate the feasibility and efficacy
of myeloablative unrelated CBT in patients aged between 50 and 55 years, we performed a retrospective comparison of 100 patients
with acute leukemia who received cord blood grafts at our institution. Nineteen older patients (median age, 52; range, 50–55)
and 81 younger patients (median, 36; range, 16–49) received a myeloablative conditioning regimen including 12 Gy of total
body irradiation and chemotherapy. GVHD prophylaxis included cyclosporine with (n = 96) or without (n = 4) methotrexate. There were no significant differences in the incidences of grades II to IV acute GVHD, extensive-type
chronic GVHD, TRM, and the probability of overall and disease-free survival between these groups. These results suggest that,
in patients with acute leukemia, myeloablative CBT might be as safe and effective in patients aged between 50 and 55 years
as in younger patients. 相似文献
49.
Yasuhiro Katsumata Masayoshi Harigai Yasushi Kawaguchi Chikako Fukasawa Makoto Soejima Tokiko Kanno Katsuji Nishimura Takayuki Yamada Hisashi Yamanaka Masako Hara 《BMC musculoskeletal disorders》2010,11(1):13
Background
Previous studies of magnetic resonance imaging (MRI) as a diagnostic tool for central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) contained several limitations such as study design, number of enrolled patients, and definition of CNS syndromes. We overcame these problems and statistically evaluated the diagnostic values of abnormal MRI signals and their chronological changes in CNS syndromes of SLE. 相似文献50.