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排序方式: 共有204条查询结果,搜索用时 671 毫秒
51.
Teachey DT Russo P Orenstein JM Didier ES Bowers C Bunin N 《Bone marrow transplantation》2004,33(3):299-302
Microsporidia are obligate, intracellular protozoal parasites that can be pathogenic in immunocompromised individuals. The majority of cases of microsporidiosis have been documented in patients with HIV, and only a few case reports exist of infection in solid organ transplant patients. We report the first case of pulmonary microsporidial infection in an allogeneic bone marrow transplant recipient in the US. The patient was a recipient of a T-cell-depleted graft who succumbed to complications from respiratory failure 63 days post transplant. The diagnosis was made post mortem by electron microscopy and confirmed with PCR. Although rare, microsporidial infection should be considered in the differential diagnosis of unexplained pulmonary infection in bone marrow transplant patients. 相似文献
52.
BACKGROUND & AIMS: Inflammation in the colon may alter motility in the proximal gut and potentiate clinical symptoms. The aim of this study was to characterize the effect of colonic anaphylaxis on local (colonic) and remote (small intestinal) motility and identify the mechanism and mediators involved. METHODS: Rats were sensitized by intraperitoneal injection of 10 microg egg albumin and surgically prepared with electrodes in jejunum and colon and a colostomy tube. Colonic and jejunal myoelectric activity were recorded in fasted animals before and after colonic antigen challenge without and then after pretreatment with specific antagonists. RESULTS: Colonic antigen challenge of sensitized rats was associated with significant (1) increase in colonic myoelectric spike activity, (2) disruption of fasting jejunal motility and initiation of aborally propagating spike complexes, and (3) increase in plasma rat mast cell protease II levels with a decrease in granulated mast cells in colon but not jejunum. The myoelectric disturbance in both colon and jejunum was inhibited significantly by pretreatment with atropine and hexamethonium, doxantrazole, cyclooxygenase, and lipoxygenase inhibitors. Methysergide inhibited only the jejunal disturbance. CONCLUSIONS: Colonic antigen challenge of sensitized animals results in local mast cell activation and the release of mediators that modulate neural pathways to initiate both a local colonic and a remote jejunal myoelectric disturbance. (Gastroenterology 1997 Jun;112(6):1996-2005) 相似文献
53.
Teachey DT 《Urology》2008,71(2):351.e5-351.e6
Vasectomy is a commonly performed urologic procedure associated with few complications. Nevertheless, a 35-year-old healthy man developed a life-threatening saddle pulmonary embolism as a consequence of a deep vein thrombosis, resulting from limited mobilization shortly after an elective vasectomy. This is the first report of a near fatal venous thromboembolic event resulting from vasectomy. 相似文献
54.
MK Song MJ Rosenthal AM Song K Uyemura H Yang ME Ament DT Yamaguchi EM Cornford 《British journal of pharmacology》2009,158(2):442-450
Background and purpose:
We have previously shown that treatment with zinc plus cyclo-(His-Pro) (CHP) significantly stimulated synthesis of the insulin degrading enzyme and lowered plasma insulin and blood glucose levels, alongside improving oral glucose tolerance in genetically type 2 diabetic Goto-Kakizaki (G-K) rats and in aged obese Sprague-Dawley (S-D) rats. Thus, we postulated that zinc plus CHP (ZC) treatment might also improve body weight control in these rats. We therefore determined the effects of ZC treatment on body weights in both genetically diabetic, mature G-K rats and non-diabetic, obese S-D rats.Experimental approach:
G-K rats aged 1.5–10 months and non-diabetic overweight or obese S-D rats aged 6–18 months were treated with 0–6 mg CHP plus 0–10 mg zinc·L−1 drinking water for 2–4 weeks, and changes in weight, serum leptin and adiponectin levels, food and water intakes were measured.Key results:
The optimal dose of CHP (in combination with zinc) to reduce weight and plasma leptin levels and to increase plasma adiponectin levels was close to 0.1 mg·kg−1·day−1, in either mature G-K rats and aged overweight or obese S-D rats. Food and water intake significantly decreased in ZC treated rats in both aged S-D rats and mature G-K rats, but not in young S-D and G-K rats.Conclusions and implications:
ZC treatment improved weight control and may be a possible treatment for overweight and obesity. 相似文献55.
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS) 总被引:2,自引:0,他引:2
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Teachey DT Obzut DA Axsom K Choi JK Goldsmith KC Hall J Hulitt J Manno CS Maris JM Rhodin N Sullivan KE Brown VI Grupp SA 《Blood》2006,108(6):1965-1971
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an increased number of double-negative T cells (DNTs). Treatment options for patients with ALPS are limited. Rapamycin has been shown to induce apoptosis in normal and malignant lymphocytes. Since ALPS is caused by defective lymphocyte apoptosis, we hypothesized that rapamycin would be effective in treating ALPS. We tested this hypothesis using rapamycin in murine models of ALPS. We followed treatment response with serial assessment of DNTs by flow cytometry in blood and lymphoid tissue, by serial monitoring of lymph node and spleen size with ultrasonography, and by enzyme-linked immunosorbent assay (ELISA) for anti-double-stranded DNA (dsDNA) antibodies. Three-dimensional ultrasound measurements in the mice correlated to actual tissue measurements at death (r = .9648). We found a dramatic and statistically significant decrease in DNTs, lymphadenopathy, splenomegaly, and autoantibodies after only 4 weeks when comparing rapamycin-treated mice with controls. Rapamycin induced apoptosis through the intrinsic mitochondrial pathway. We compared rapamycin to mycophenolate mofetil, a second-line agent used to treat ALPS, and found rapamycin's control of lymphoproliferation was superior. We conclude that rapamycin is an effective treatment for murine ALPS and should be explored as treatment for affected humans. 相似文献
56.
B. FRIIS F. KARUP PEDERSEN M. SCHIØDT A. WIIK L. HØJ V. ANDERSEN 《Acta paediatrica (Oslo, Norway : 1992)》1983,72(2):265-268
ABSTRACT. In two children with recurrent parotitis, labial salivary gland biopsies showed chronic sialoadenitis. Immunofluorescence studies disclosed deposits of immunoglobulins and complement in juxta-acinar small vessels. Case 1 had gluten enteropathy, IgA deficiency and high titres of antinuclear antibodies (ANA), and in vivo fixation of ANA to nuclei of different cells in lip, skin and jejunum was present. Case 2 showed deposition of IgM in the dermo-epidermal junction of the skin. These findings suggest that autoimmune reactivity and immune complexes may play a role in the pathogenesis of this disorder. 相似文献
57.
Orenstein JM Russo P Didier ES Bowers C Bunin N Teachey DT 《Ultrastructural pathology》2005,29(3-4):269-276
Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of microsporidiosis have been reported during the past 20 years, in patients with HIV/AIDS, while only relatively rare cases have been described in immunocompetent individuals. However, microsporidia infections are being increasingly reported in patients following solid-organ transplanation, where the main symptom has been diarrhea. The authors report the first case of pulmonary microsporidial infection in an allogeneic bone marrow transplant recipient in the United States and only the second case in the world. The patient, with a history of Hodgkin disease followed by acute myelogenous leukemia received a T-cell-depleted graft, but succumbed to respiratory failure 63 days post transplantation. An open lung biopsy, taken just before death, was originally thought to show toxoplasmosis. The correct diagnosis of microsporidiosis was made postmortem by light and electron microscopy. DNA polymerase chain reaction analysis confirmed the diagnosis and furthermore revealed it to be the dog strain of the microsporidia species Encephalitozoon cuniculi. Although to date rarely diagnosed, microsporidial infection should also be considered in the differential diagnosis of, e.g., unexplained pulmonary infection in bone marrow transplant patients. 相似文献
58.
Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC) 总被引:1,自引:1,他引:1
Kelsell DP; Risk JM; Leigh IM; Stevens HP; Ellis A; Hennies HC; Reis A; Weissenbach J; Bishop DT; Spurr NK; Field JK 《Human molecular genetics》1996,5(6):857-860
Focal non-epidermolytic palmoplantar keratoderma (PPK or palmoplantar
ectodermal dysplasia type III) is associated with oesophageal cancer in
three families: two large pedigrees located in Liverpool, UK and in the
midwestern American states and one smaller family from Germany. In these
families, the PPK is inherited as autosomal dominant and has a late onset,
usually manifesting between 7 and 8 years of age. The disease is
characterised by thickening of the pressure areas of the soles, but is not
restricted to the feet and also presents with oral leukokeratosis and
follicular hyperkeratosis. The disease locus [previously termed the
"tylosis oesophageal cancer gene' (TOC) locus] has been mapped to
17q23-qter by linkage analysis. This region is located telomeric to the
keratin 16 gene, in which mutations have been identified in focal PPK
families who show no increased cancer risk. We describe the close mapping
of this locus to the interval between AFMb054zf9 and D17S1603 using
haplotype analysis of additional Genethon markers in the region and show
that although the American family is unlikely to be related to either of
the other two, the UK and German pedigrees may share a common descent. This
work provides a basis for positional cloning and candidate gene analysis in
order to identify a gene that may be involved in familial oesophageal
cancer.
相似文献
59.
Tetsuo Ichikawa DDS PhD Osamu Ishida DT Megumi Watanabe DDS PhD Yoritoi Tomotake DDS PhD Hua Wei DDS PhD & Chen Jianrong DDS PhD 《Journal of prosthodontics》2008,17(6):487-489
This article discusses two methods for improving the retrievability of cement-retained implant superstructures. One method involves incorporating a removal screw in the superstructure and the second method uses a small dimple on the abutment, accessed through a vent in the superstructure. 相似文献
60.
In women there is a gradual rise in the basal level of follicle stimulating
hormone (FSH) in the years prior to the menopause (pre- menopause) which is
thought to be due to a relative lack of ovarian factors reflecting the
number of antral follicles present in the ovaries. Experimental animal
models for this phenomenon, particularly in mono-ovulatory species, have
been lacking due to most animals' relatively short life span. We have
available a group of experimental ewes in which the right ovary was removed
and the left ovary was autotransplanted to the neck at least 10 years
previously, which have been maintained in good health until an age of 12-13
years. Two experiments were conducted with these animals to determine the
endocrine and follicular effects of age: a retrospective experiment in the
same Finn-Merino ewes (n = 5) when the animals were 6-7 or 12-13 years of
age; and a cohort experiment in old (12-13 years, n = 6) and young (2
years, n = 5) ewes of the same breed. In both retrospective and cohort
experiments, the concentrations of FSH were significantly higher (P <
0.05) in older animals during the luteal phase when oestradiol secretion
was low. This increase in FSH was associated with a decrease in the
concentration of inhibin A (P < 0.05) in older animals in both the
follicular and luteal stages of the cycle but the concentrations of
oestradiol were similar between ages. Although there were significantly
fewer antral follicles (P < 0.05) available for development in older
ewes during the early luteal phase of the cycle, the ovulation rate was
similar to that observed in younger animals (2.0+/-0 vs 2.0+/-4; P >
0.05) but the interval from luteal regression to the onset of the LH surge
was longer (P < 0.05) in older animals. In conclusion, the endocrine
changes associated with increasing reproductive age in sheep are therefore
similar to those observed in women, suggesting that the sheep could be a
useful animal model to study the effect of age on human fertility.
相似文献