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111.
The hepatitis B immunization programme in Singapore 总被引:2,自引:0,他引:2
K T Goh S Doraisingham K L Tan C J Oon M L Ho A J Chen S H Chan 《Bulletin of the World Health Organization》1989,67(1):65-70
A voluntary immunization programme to prevent perinatal transmission of hepatitis B virus (HBV) infection in Singapore was implemented on 1 October 1985 as an integral component of the national childhood immunization programme. Up to April 1988, a total of 68,845 mothers who attended government maternal and child health clinics were screened for the disease. Of these, 2432 (3.5%) were positive for hepatitis B surface antigen (HBsAg) and 904 (1.3%) for hepatitis B e antigen (HBeAg). Virtually all the babies born to carrier mothers completed the full immunization schedule; and in addition, those of HBeAg-positive mothers were given a dose of hepatitis B immunoglobulin at birth. The hepatitis B immunization programme was extended on 1 September 1987 to cover all newborns. About 90% of the 15,943 babies delivered in government institutions from September 1987 to April 1988 were immunized at birth, with the subsequent doses being administered at maternal and child health clinics at 4-6 weeks and 5 months later. More than 85% of the children given the full course of plasma-derived and yeast-derived hepatitis B vaccine from birth continued to have protective antibody to HBV two years after immunization. The programme is being closely monitored to assess the duration of immunity and the need for booster doses, while seronegative adults are also being encouraged to be vaccinated. 相似文献
112.
The most outstanding pathological changes of perinatal babies and children, based on the review of the autopsy files in the 1st Affiliated Hospital of West China University of Medical Sciences, are lymphocytic depletion, and reticuloepithelial cell swelling and/or fusiform malformation in the cortex, while in the medulla apoptosis is more prominent. We suppose that these alterations are due to immaturity of cortical thymocytes, and in the diseased condition, they are easily affected by extraordinary factors, especially the influence of corticosterone inducing acute severe necrosis, so the number of lymphocytes are obviously diminished. But, in the medulla, as intact mature lymphocytes exist, physiological phenomenon such as apoptosis is rather prominent in it. While in the medulla, Hassall's corpuscles have various characteristic changes, such as cornification, calcification, fusion, cystic change and disintegration. Besides, we observed a new alteration in the thymus defined as vacuolization. All the above pathological changes reached the peak in the 28- day group; there after, they might become either worse or better according to the condition of the disease and growth of the body. However, these are still problems to be further studied separately. 相似文献
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目的:考察不同溶媒配制的诺氟沙星对照品溶液能否保存。方法:用紫外分光光度法分别对5℃放置的使用不同溶媒的对照品溶液在0d、10d、20d、30d、40d测定最大吸收波长、吸收值。结果;以0.4%NaOH溶液为溶媒的诺氟沙星对照液于5℃放置40d,最大吸收波长、吸收值均未发生变化(无显著性差异P>0.05)。而以pH4.0醛酸缓冲液、pH7.4磷酸盐缓冲液为溶媒的两种对照液5℃放置40d,最大吸收波长未发生变化,但吸收值明显降低(有显著性差异P<0.05)。结论:用0.4%NaOH溶液配制的诺氟沙星对照品溶液在适宜的条件下(5℃,避光密闭)保存,40d内是稳定的,可继续使用。而用pH4.0醋酸缓冲注和pH7.4磷酸盐缓冲液配制的诺氟沙星对照品溶液则不能保存使用,必须临用新配。 相似文献
116.
AnAnalysisofChromosomeonSterilityCausedbyAzoospermiaorOligospermia¥WuMeiheng;TangWingnuo.(ACTAACADEMIAEMEDICINAENANJING,1995(... 相似文献
117.
本文报道 ̄99mTc-新半乳糖白蛋白( ̄99mTc-NGA)与大鼠肝细胞膜进行体外结合试验。结果表明: ̄99mTc-NGA系与肝细胞膜上的高亲和力低容量(K_1:8.4089×10 ̄9L/mol;R_1:1.7350×10 ̄(-12)mol/mg)和低亲和力高容量(K_2:2.0827×10 ̄8L/mol;R_2:6.9530×10 ̄(-12)mol/mg)2个结合位点相结合,其结合表现出高特异性、可饱和性及对细胞膜蛋白浓度的线性依赖性,具备受体介导结合的基本特征。 ̄(99m)Tc-NGA是一个很有希望的肝受体显像剂。 相似文献
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119.
H Yamanaka E H Willis C A Penning C L Peebles E M Tan D A Carson 《The Journal of clinical investigation》1987,80(3):900-904
The chromatin-bound enzyme poly(ADP-ribose) polymerase (ADPRP) is strongly stimulated by DNA with single- or double-stranded breaks, and transfers the ADP-ribose moiety of NAD to nuclear proteins. The activation of ADPRP is important for DNA repair and replication, and also has been postulated to play a role in the pathogenesis of lymphocyte dysfunction associated with chronic inflammatory diseases, and inborn errors of nucleoside metabolism. We have detected high titers of IgG autoantibodies to the ADPRP protein in six patients with rheumatic complaints. No other autoantibodies were detected in any of the six sera. The specificity of the anti-enzyme antibodies was established by (a) immunoprecipitation of ADPRP activity, (b) immunoprecipitation and immunoblotting of both the native 116-kD enzyme and its proteolytic digestion products. ADPRP was purified from human thymus and calf thymus. The autoantibodies reacted equivalently with both enzymes. The anti-ADPRP antibodies had a distinctive immunofluorescent pattern with HEp-2 cells, reacting intensely with nucleoli and metaphase chromosomes, and diffusely with the nucleus. Autoantibodies to ADPRP have not been described previously. The presence of a specific immune response against an enzyme that has been associated with various immunodeficiency syndromes raises intriguing possibilities concerning the relationship between DNA damage, immunodeficiency, and autoimmunity. 相似文献
120.
E C Tan 《The Journal of dermatologic surgery and oncology》1989,15(3):270-272
The punch technique of repairing pierced earlobe deformities is a practical and simplified alternative to the usual method of repair. The procedure can easily be performed in any dermatology office since the instruments required are very basic. The technique is presented in a series of illustrations, and the results are cosmetically acceptable. 相似文献